A comprehensive review of biological and materials properties of Tantalum and its alloys

Mani, Gopinath; Porter, Deanna; Grove, Kent; Collins, Shell; Örnberg, Andreas; Shulfer, Robert

doi:10.1002/jbm.a.37373

Cited by 32 publications

(16 citation statements)

References 110 publications

(301 reference statements)

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“…Frontiers in Bioengineering and Biotechnology frontiersin.org (2021), a bismuth nitrate-loaded cisplatin prodrug (NP@PVP) was synthesised to enhance DNA damage after RT by improving the amount of ROS production; meanwhile, cisplatin in NP@PVP can be released slowly to inhibit DNA damage repair, with temporal and spatial synchronisation. Tantalum (Ta) is a non-toxic, biologically inert element with a large atomic number (Z = 73) and is a "biophilic metal" with excellent biocompatibility, and it has been widely used in medical implants in the human body (Koshevaya et al, 2021;Mani et al, 2022). According to previous studies, Ta-based nanomaterials can not only be applied as low-toxicity and high-efficiency radiosensitizers but can also be utilised as excellent functional group carriers for loading drugs to modulate the biological behaviour of tumors, which has the advantage of "multifunctional integration" and exhibits considerable potential for biomedical applications (Song et al, 2017b;Chen et al, 2017).…”

Section: Methodsmentioning

confidence: 99%

“…Tantalum (Ta) is a non-toxic, biologically inert element with a large atomic number (Z = 73) and is a “biophilic metal” with excellent biocompatibility, and it has been widely used in medical implants in the human body ( Koshevaya et al, 2021 ; Mani et al, 2022 ). According to previous studies, Ta-based nanomaterials can not only be applied as low-toxicity and high-efficiency radiosensitizers but can also be utilised as excellent functional group carriers for loading drugs to modulate the biological behaviour of tumors, which has the advantage of “multi-functional integration” and exhibits considerable potential for biomedical applications ( Song et al, 2017b ; Chen et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Tantalum-carbon-integrated nanozymes as a nano-radiosensitizer for radiotherapy enhancement

Zhao²,

Wu³

et al. 2022

Front. Bioeng. Biotechnol.

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Radiotherapy (RT) plays a pivotal role in the comprehensive treatment of multiple malignant tumors, exerting its anti-tumor effects through direct induction of double-strand breaks (DSBs) or indirect induction of reactive oxygen species (ROS) production. However, RT resistance remains a therapeutic obstacle that leads to cancer recurrence and treatment failure. In this study, we synthesised a tantalum-carbon-integrated nanozyme with excellent catalase-like (CAT-like) activity and radiosensitivity by immobilising an ultrasmall tantalum nanozyme into a metal-organic framework (MOF)-derived carbon nanozyme through in situ reduction. The integrated tantalum nanozyme significantly increased the CAT activity of the carbon nanozyme, which promoted the production of more oxygen and increased the ROS levels. By improving hypoxia and increasing the level of ROS, more DNA DSBs occur at the cellular level, which, in turn, improves the sensitivity of RT. Moreover, tantalum–carbon-integrated nanozymes combined with RT have demonstrated notable anti-tumor activity in vivo. Therefore, exploiting the enzymatic activity and the effect of ROS amplification of this nanozyme has the potential to overcome resistance to RT, which may offer new horizons for nanozyme-based remedies for biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tantalum-carbon-integrated nanozymes as a nano-radiosensitizer for radiotherapy enhancement

Zhao²,

Wu³

et al. 2022

Front. Bioeng. Biotechnol.

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“…Tantalus was a Greek mythological figure who was condemned to a famous punishment; he had to stand in a water pool under a tree, but he was not allowed to drink the water or to eat the fruits. The myth illustrates the refractory property of tantalum that is highly unreactive in almost all acids, with the exception of hydrofluoric acid and acids containing fluoride and sulfur trioxide [ 22 ].…”

Section: Tantalum and Its Propertiesmentioning

confidence: 99%

“…However, most of the power transmitted during MRI is converted into heat inside the patient’s body; the metallic device can be heated up, depending on the size and geometry of the implant. It is important to calculate the amount of heat generated during MRI and to predict any possible adverse effect [ 22 ]. Two studies [ 29 , 30 ] calculated the temperature variation inside the human body in order to check Ta compatibility during MRI examinations of different stents.…”

Section: Tantalum and Its Propertiesmentioning

confidence: 99%

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Carraro

Bagno

2023

Biomimetics

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During the last 20 years, tantalum has known ever wider applications for the production of endosseous implantable devices in the orthopedic and dental fields. Its excellent performances are due to its capacity to stimulate new bone formation, thus improving implant integration and stable fixation. Tantalum’s mechanical features can be mainly adjusted by controlling its porosity thanks to a number of versatile fabrication techniques, which allow obtaining an elastic modulus similar to that of bone tissue, thus limiting the stress-shielding effect. The present paper aims at reviewing the characteristics of tantalum as a solid and porous (trabecular) metal, with specific regard to biocompatibility and bioactivity. Principal fabrication methods and major applications are described. Moreover, the osteogenic features of porous tantalum are presented to testify its regenerative potential. It can be concluded that tantalum, especially as a porous metal, clearly possesses many advantageous characteristics for endosseous applications but it presently lacks the consolidated clinical experience of other metals such as titanium.

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“…Other biocompatible transition metal oxides have also shown promising biological properties such as osseointegration, improved cell adhesion and proliferation, decreased inflammatory response and antibacterial properties, along with exhibiting very good corrosion and wear resistance [ 10 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. However, a significantly smaller number of works have studied the biological response of promising oxides, such as Nb 2 O 5 and Ta 2 O 5 [ 44 , 45 , 46 , 47 , 48 , 49 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

et al. 2022

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Biomaterials with adequate properties to direct a biological response are essential for orthopedic and dental implants. The surface properties are responsible for the biological response; thus, coatings with biologically relevant properties such as osteoinduction are exciting options to tailor the surface of different bulk materials. Metal oxide coatings such as TiO2, ZrO2, Nb2O5 and Ta2O5 have been suggested as promising for orthopedic and dental implants. However, a comparative study among them is still missing to select the most promising for bone-growth-related applications. In this work, using magnetron sputtering, TiO2, ZrO2, Ta2O5, and Nb2O5 thin films were deposited on Si (100) substrates. The coatings were characterized by Optical Profilometry, Scanning Electron Microscopy, Energy-Dispersive X-ray Spectroscopy, X-ray Photoelectron Spectroscopy, X-ray Diffraction, Water Contact Angle measurements, and Surface Free Energy calculations. The cell adhesion, viability, proliferation, and differentiation toward the osteoblastic phenotype of mesenchymal stem cells plated on the coatings were measured to define the biological response. Results confirmed that all coatings were biocompatible. However, a more significant number of cells and proliferative cells were observed on Nb2O5 and Ta2O5 compared to TiO2 and ZrO2. Nevertheless, Nb2O5 and Ta2O5 seemed to induce cell differentiation toward the osteoblastic phenotype in a longer cell culture time than TiO2 and ZrO2.

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A comprehensive review of biological and materials properties of Tantalum and its alloys

Cited by 32 publications

References 110 publications

Tantalum-carbon-integrated nanozymes as a nano-radiosensitizer for radiotherapy enhancement

Tantalum-carbon-integrated nanozymes as a nano-radiosensitizer for radiotherapy enhancement

Tantalum as Trabecular Metal for Endosseous Implantable Applications

Evaluation of the Biocompatibility and Osteogenic Properties of Metal Oxide Coatings Applied by Magnetron Sputtering as Potential Biofunctional Surface Modifications for Orthopedic Implants

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