A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments

Sharma, Ganesh N.; Gupta, Gaurav; Sharma, Piyush

doi:10.1615/critreveukaryotgeneexpr.2018022258

Cited by 86 publications

(55 citation statements)

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“…Long term administration of DLM in rabbits initiated significant oxidative DNA harm in the liver and kidney and fundamentally decreased plasma CAT, GSH, and TAC levels. [39][40][41] The serum levels of TNF-α, lactate dehydrogenase, alanine transaminase, and aspartate aminotransferase were fundamentally increased by subacute administration of DLM in rats. In the present examination, the prior treatment with Sita and additionally Cur at a dose of 100 mg/kg for each, decreased the serum kidney damage markers.…”

Section: Resultsmentioning

confidence: 99%

“…The pesticide DML was accounted for in expanding MDA in renal tissue, serum creatinine, and urea, while cell antioxidative markers were diminished in rats. Long term administration of DLM in rabbits initiated significant oxidative DNA harm in the liver and kidney and fundamentally decreased plasma CAT, GSH, and TAC levels . The serum levels of TNF‐α, lactate dehydrogenase, alanine transaminase, and aspartate aminotransferase were fundamentally increased by subacute administration of DLM in rats.…”

Section: Discussionmentioning

confidence: 99%

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Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Shi

Zhang

Wang

et al. 2019

J Biochem & Molecular Tox

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Deltamethrin (DLM) is a synthesized organophosphorus acaricide and bug spray, broadly utilized for veterinary and farming purposes. Although its exposure to humans and animals causes toxicity in the kidney and other primary organs, our objective was to assess the defensive effects of sitagliptin (Sita) and additionally curcumin (Cur) in the DLM‐intoxicated rats’ kidney. DLM‐intoxicated rats revealed a huge increase of various biochemical parameters in serum identified with kidney damage: uric acid, urea, and creatinine. DLM intoxication altogether increased renal lipid peroxidation, and critically restrained antioxidative biomarkers including superoxide dismutase, glutathione, and glutathione peroxidase. Likewise, it increased the tumor necrosis factor‐α, interleukin 6 (IL‐6) and IL‐1β level in serum. Additionally, DLM intoxication diminished the outflow of the nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2)/heme oxygenase‐1 (HO‐1) pathway in rats. Both Sita and Cur act against DLM‐prompted serum along with renal tissue biochemical parameters when utilized alone or in a mix alongside DLM intoxication. Besides this, both Sita and Cur delivered synergetic nephroprotective, antioxidative, and anti‐inflammatory impacts. Consequently, it could be presumed that Sita as well as Cur administration can limit the poisonous impacts of DLM by their free radical‐scavenging, strong antioxidant, and Nrf2/HO‐1 pathway upregulation activity.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Shi

Zhang

Wang

et al. 2019

J Biochem & Molecular Tox

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show abstract

“…Due to the necrosis of the renal tubular cells, the water reabsorption capacity decreases in the manifold, thus increasing the loss of fluid through urine (Corman, Roinel, & De Rouffignac, ). The increase in the kidney ratio value may be due to edema of renal parenchyma, which is caused by administration of GM that triggers renal inflammation (Faubel, Patel, Lockhart, & Cadnapaphornchai, ; Sharma, Gupta, & Sharma, ).…”

Section: Discussionmentioning

confidence: 99%

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

et al. 2019

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Gentamicin (GM) is an antibiotic related to aminoglycoside group that is used in treating Gram‐negative bacterial infections. However, treatment with gentamicin is considered to be limited as it induces an oxidative stress‐mediated apoptosis in kidney which causes a nephrotoxicity. Metformin is a well‐known biguanide that is used for treating diabetes mellitus, especially type 2. Supplement with plant metabolites or natural antioxidants produce a protective activity against many types of diseases in vivo. Curcumin is a main medicinal constituent of Curcuma longa, has reported for number of biological effects, such as antioxidant, anti‐inflammatory, and antitumor. The study aims at evaluating the metformin and curcumin alone or in combination on nephrotoxicity induced by GM. The outcome of the study shows that both metformin and curcumin, when used unaided, were effectively decreasing GM‐induced nephrotoxicity. The two drugs combination was showed synergistic effect in ameliorating a GM‐induced kidney injury, as supported by expressively improved renal dysfunction. Metformin and curcumin showed strong protection against oxidative stress in GM treated animals through decreasing the activities and expression of various antioxidative enzymes. Moreover, combination of two drugs showed an anti‐inflammatory response through reducing a level of pro‐inflammatory cytokines including tumor necrosis factor‐alpha, interleukin 1‐beta, and interleukin 6 in GM intoxicated group of animals. Furthermore, GM agitated apoptosis was affectedly diminished by the combinational treatment of metformin and curcumin via down‐regulating activity of cleaved Caspase‐3 and pro‐apoptotic factor Bax, whereas increasing anti‐apoptotic factor Bcl‐2 signaling pathways. The above results suggested that combinational treatment of metformin and curcumin might be have a synergizing effect and substantial potential against nephrotoxicity induced by GM. Practical applications Curcumin and metformin combination exhibited substantial synergistic effect against GM‐induced nephrotoxicity through reducing oxidative stress, inflammation, as well as apoptosis in kidney cells. Therefore, the method of combination of curcumin and metformin might be functional to treat or inhibit GM prompted nephrotoxicity in future.

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“…hematocrit are the predictors for increased Hcy concentration [50][51][52]. Moreover, the various studies have explored significant correlations between Hcy, UA, and creatinine [53,54].…”

Section: Synthesis and Metabolism Of Homocysteinementioning

confidence: 99%

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

Singh¹,

Samuel

Dahiya

et al. 2019

Biotech and App Biochem

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Homocysteine [HSCH2CH2CH(NH2)COOH] (Hcy) is a sulfur‐containing amino acid of 135.18 Da of molecular weight, generated during conversion of methionine to cysteine. If there is a higher accumulation of Hcy in the blood, that is usually above 15 µmol/L, it leads to a condition referred to as hyperhomocysteinemia. A meta‐analysis of observational study suggested an elevated concentration of Hcy in blood, which is termed as the risk factors leading to ischemic heart disease and stroke. Further experimental studies stated that Hcy can lead to an increase in the proliferation of vascular smooth muscle cells and functional impairment of endothelial cells. The analyses confirmed some of the predictors for Hcy presence, such as serum uric acid (UA), systolic blood pressure, and hematocrit. However, angiotensin‐converting enzyme inhibitors angiotensin‐converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) alone are inadequate for controlling UA and creatinine level, although the addition of folic acid may be beneficial in hypertensive patients who are known to have a high prevalence of elevated Hcy. We hypothesized that combination therapy with an ARB (olmesartan) and folic acid is a promising treatment for lowering the UA and creatinine level in hyperhomocysteinemia‐associated hypertension.

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A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments

Cited by 86 publications

References 0 publications

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro‐inflammatory cytokines and Nrf2/Ho‐1 pathway

Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

Combinational effect of angiotensin receptor blocker and folic acid therapy on uric acid and creatinine level in hyperhomocysteinemia‐associated hypertension

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