A comprehensive review of herbacetin: From chemistry to pharmacological activities

Wei, Xiaohan; Zhao, Zhe-jun; Zhong, Rongheng; Tan, Xiaomei

doi:10.1016/j.jep.2021.114356

Cited by 23 publications

(10 citation statements)

References 106 publications

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“…Only information about extraction of rutin, isoquercitrin, quercimeritrin, herbacetin, coumarin, scopoletin, and scopolin in the aboveground part of the S. hermaphrodita were reported a long time ago [ 15 , 16 ]. All these compounds are known to have biological and pharmacological effects [ 17 , 18 , 19 , 20 , 21 , 22 ]. Even based on limited information, it can be concluded that S. hermaphrodita can be an interesting plant with a wide range of uses.…”

Section: Introductionmentioning

confidence: 99%

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Kaňuková

Gubišová

Klčová

et al. 2022

IJMS

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The in vitro cultures of plant stem cells and stem cell-like cells can be established from tissues containing meristematic cells. Chemical compounds—as well as their production potential—is among the emerging topics of plant biotechnology. We induced the callus cell biomass growth and characterized the parameters indicating the presence of stem cells or stem cell-like cells. Four types of explants (stem, petiole, leaf, root) from Sida hermaphrodita (L.) Rusby and various combinations of auxins and cytokinins were tested for initiation of callus, growth of sub-cultivated callus biomass, and establishment of stem cells or stem cell-like cells. Induction of callus and its growth parameters were significantly affected both by the explant type and the combination of used plant growth hormones and regulators. The responsibility for callus initiation and growth was the highest in stem-derived explants containing cambial meristematic cells. Growth parameters of callus biomass and specific characteristics of vacuoles confirmed the presence of stem cells or stem cell-like cells in sub-cultivated callus cell biomass. Establishment of in vitro stem cell or stem cell-like cell cultures in S. hermaphrodita can lead to the development of various applications of in vitro cultivation systems as well as alternative applications of this crop.

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Section: Introductionmentioning

confidence: 99%

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Kaňuková

Gubišová

Klčová

et al. 2022

IJMS

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“…There are thousands of known herbs consist of various bioactive compounds [27][28][29][30]. But if we were to test for example 5,000 herbs and only make combinations of 2, then we have 12,497,500 combinations.…”

Section: Data Curation and Computational Analysis To Find The Effecti...mentioning

confidence: 99%

Data mining and experimental approaches to identify combination of natural herbs against bacterial infections

Mittal

Duncan²,

Chamberlin

2022

Preprint

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Various studies have identified that natural herbs can be repurposed to treat infectious and bacterial diseases. The purpose of this study is first to test the medicinal value of five herbs including asafoetida, cumin, fenugreek, neem, and turmeric as single agent and in pairs using the bacterial zone of inhibition assay. Second, we used target and network analyses to predict the best combinations. We found that all the herbs as single agent were effective against bacterial infection in the following descending order of efficacy: cumin > turmeric > neem > fenugreek > asafoetida as compared to vehicle (ethanol) treated control. Among all the tested combinations the turmeric and fenugreek combination had the best efficacy in inhibiting the bacterial growth. Next to understand the mechanism of action and to predict the effective combinations among available herbs, we used a data mining and computational analysis approach. Using NPASS, BindingDB, and pathway analysis tools, we identified the bioactive compounds for each herb, then identified the targets for each bioactive compound, and then identified associated pathways for these targets. Then we measured the target/pathway overlap for each herb and identified that the most effective combinations were those which have non-overlapping targets/pathways. For example, we showed as a proof-of-concept that turmeric and fenugreek have the least overlapping targets/pathways and thus is most effective in inhibiting bacteria growth. Our approach is applicable to treat bacterial infections and other human diseases such as cancer. Overall, the computational prediction along with experimental validation can help identify novel combinations that have significant antibacterial activity and may help prevent drug-resistant microbial diseases in human and plants.

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“…Usually, the body keeps up a balance between the production of free radicals and their elimination. However, overproduction of reactive oxygen species leads to a disproportion between pro and antioxidants, resulting in oxidative stress [113]. Oxidative stress disrupts and damages DNA, cell structures, proteins, and lipids in the body and consequently results in neurodegenerative diseases, cancer, and diabetes, among others [113,114].…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…However, overproduction of reactive oxygen species leads to a disproportion between pro and antioxidants, resulting in oxidative stress [113]. Oxidative stress disrupts and damages DNA, cell structures, proteins, and lipids in the body and consequently results in neurodegenerative diseases, cancer, and diabetes, among others [113,114]. Antioxidants are useful chemical compounds that can reduce free radicals, decrease the rate of production, and even quench free radicals in the body [115].…”

Section: Antioxidant Activitymentioning

confidence: 99%

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

Olatunji

Adetunji

Olisah

et al. 2021

Plants

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The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

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A comprehensive review of herbacetin: From chemistry to pharmacological activities

Cited by 23 publications

References 106 publications

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Establishment of Stem Cell-like Cells of Sida hermaphrodita (L.) Rusby from Explants Containing Cambial Meristems

Data mining and experimental approaches to identify combination of natural herbs against bacterial infections

Research Progression of the Genus Merremia: A Comprehensive Review on the Nutritional Value, Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity

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