A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

Pan, Xiaoqi; Ma, Xiao; Jiang, Yinxiao; Wen, Jianxia; Yang, Lian; Chen, Dayi; Cao, Xiaoyu; Peng, Cheng

doi:10.1155/2020/7171498

Cited by 36 publications

(20 citation statements)

References 231 publications

(205 reference statements)

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“…Many researchers are conducting different research on medicinal plants around the world and reporting their biological activities, identifying new bioactive molecules to treat different diseases including liver diseases [29,30]. In recent years many medicinal plants and herbal formulations were reported about their potentiality against different liver diseases [31]. In this point of view, the current research was aimed to explore phytochemical profile and evaluate hepatoprotective activity of Elytraria acaulis.…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Hepatoprotective Activity of Elytraria acaulis

Sankar

Venkateswarlu

Ramana³

2021

JPRI

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Introduction: The emerging of new diseases, resistance to contemporary using drugs and inadequate usage of commonly available drugs leading to different side effects and sometimes to mortality. So, there is need to identify efficient drugs from easily available sources. Traditional medicines from medicinal plants have been using since ancient times to treat different diseases, are easily available herbal formulations and there were still many medicinal plants were unexplored about their therapeutic potentiality. So, the current research is aimed to explore phytochemical constituent and hepatoprotective potentiality of Elytraria acaulis on paracetamol-induced liver toxicity. Methodology: The root parts Elytraria acaulis were used for extraction through maceration procedure using hexane, ethyl acetate and hydro-alcoholic (70% ethanol). The dried extracts used for further for phytochemical analysis using standard procedures and evaluated liver protection on paracetamol-induced liver toxicity by estimating liver bio markable enzymes such as AST (SGOT), ALT (SGPT), ALP and total bilirubin levels. Results: Qualitative phytochemical screening of E. acaulis extracts revealed the presence of different phytochemical constituents like steroids, terpenoids, flavonoids, alkaloids, glycosides, phenols, tannins, saponins and carbohydrates in them. The hydroalcoholic extract has more flavonoid content i.e., 23.84±0.28 (mg/gm) than other two extracts. The tested three extracts of E. acaulis had showed concentration dependent hepatoprotective activity. Among three extracts hydro-alcoholic extract had more potentially compared to other two extracts. The percentage protection produced by the hydro-alcoholic extract on the enhancement of AST(SGOT), ALT (SGPT), ALP and total bilirubin levels were 21.54%, 21.94%, 21.20%, and 20.52%, 36.27%, 38.26%, 37.55% and 36.14%, 67.76%, 70.04%, 69.83% and 68.61% respectively. Conclusion: The Elytraria acaulis root extracts had showed significant biological activities and own different phytochemical constituents. The hydroalcoholic extract possess more phenolic, flavonoid contents and the same had showed more potentiality against liver toxicity. The current results offer vital information about the traditional medicinal value of it. The further research is valuable and is under progress in evaluation of different biological activities and isolation of individual bioactive molecules from E. acaulis.

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Section: Resultsmentioning

confidence: 99%

Phytochemical Analysis and Hepatoprotective Activity of Elytraria acaulis

Sankar

Venkateswarlu

Ramana³

2021

JPRI

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“…Other compounds that were allegedly able to increase Kupffer cells in this study were flavonoids. A research review from Pan et al (2020) stated that flavonoids in plants could activate immune cells, especially Kupffer cells in the liver. The increase in Kupffer cells in rats given the extract of Sappan wood is beneficial for increasing the immune system in the body and can be helpful in the performance of liver cells and their metabolism (Susanto et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Toxicity Studies of Sappan Wood Extract on The Kupffer Cells Number in Rats (Rattus novergicus)

et al. 2022

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Sappan wood (Caesalpinia sappan L.) is a plant used by the community to mix drinking. The antioxidant index of Sappan wood extract has a higher value than commercial antioxidants to counteract oxidative free radicals and improve the body's defense system. The use of Sappan wood drinking in society is often used in daily so it is necessary to do a chronic toxicity test to observe the response to prolonged use of the system in the body. Kupffer cells are an important part of the innate immune system, acting as “scavengers” and phagocytes. A study that aims to see the chronic toxicity studies of the ethanolic extract of Sappan wood on the number of Kuffer cells in the liver has been carried out on 60 Wistar rats divided into 12 groups. The group was the negative control group, doses 100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW and 500 mg/kgBW of extract Sappan wood which were divided into male and female groups. Each group was given ethanol extract of Sappan wood for one year orally. The results showed a significant increase in Kupffer cells in the female group at a dose of 100 mg/kgBW and the male group at 200 mg/kgBW with significant values, respectively, p<0.001 p = 0.004.

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“…Notably, there is growing evidence that TCM is effective in the prevention and treatment of liver fibrosis (Pan et al, 2020). TCM can suppress liver fibrosis activity through different mechanisms, including inhibition of cytokine production and suppression of HSCs activation, as well as regulating the progression of liver fibrosis through other molecular mechanisms (Shan et al, 2019).…”

Section: Traditional Chinese Medicine With Multiple Effects On Liver ...mentioning

confidence: 99%

Molecular Mechanisms and Potential New Therapeutic Drugs for Liver Fibrosis

2022

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Liver fibrosis is the pathological process of excessive extracellular matrix deposition after liver injury and is a precursor to cirrhosis, hepatocellular carcinoma (HCC). It is essentially a wound healing response to liver tissue damage. Numerous studies have shown that hepatic stellate cells play a critical role in this process, with various cells, cytokines, and signaling pathways engaged. Currently, the treatment targeting etiology is considered the most effective measure to prevent and treat liver fibrosis, but reversal fibrosis by elimination of the causative agent often occurs too slowly or too rarely to avoid life-threatening complications, especially in advanced fibrosis. Liver transplantation is the only treatment option in the end-stage, leaving us with an urgent need for new therapies. An in-depth understanding of the mechanisms of liver fibrosis could identify new targets for the treatment. Most of the drugs targeting critical cells and cytokines in the pathogenesis of liver fibrosis are still in pre-clinical trials and there are hardly any definitive anti-fibrotic chemical or biological drugs available for clinical use. In this review, we will summarize the pathogenesis of liver fibrosis, focusing on the role of key cells, associated mechanisms, and signaling pathways, and summarize various therapeutic measures or drugs that have been trialed in clinical practice or are in the research stage.

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A Comprehensive Review of Natural Products against Liver Fibrosis: Flavonoids, Quinones, Lignans, Phenols, and Acids

Cited by 36 publications

References 231 publications

Phytochemical Analysis and Hepatoprotective Activity of Elytraria acaulis

Phytochemical Analysis and Hepatoprotective Activity of Elytraria acaulis

Effect of Chronic Toxicity Studies of Sappan Wood Extract on The Kupffer Cells Number in Rats (Rattus novergicus)

Molecular Mechanisms and Potential New Therapeutic Drugs for Liver Fibrosis

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