A Comprehensive Review of Ovarian Serous Carcinoma

Hatano, Yuichiro; Hatano, Kayoko; Tamada, Maho; Morishige, Ken Ichirou; Tomita, Hiroyuki; Yanai, Hiroyuki; Hara, Akira

doi:10.1097/pap.0000000000000243

Cited by 47 publications

(45 citation statements)

References 115 publications

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“…У свою чергу, тип ІІ, що відповідно має за аналог "high-grade" серозну карциному, характеризується високим рівнем генетичної нестабільності із 81 20/ Том XXV / 1 залученням мутації ТР53. Вірогідно мають місце й різні шляхи канцерогенезу цих двох типів серозних карцином яєчників [3,13,18].…”

Section: Results Group Immunophenotypes Showed Uniformity In the Expunclassified

Importance of serous intraepithelial ovarian tubal carcinomas in the occurrence of "high-grade" serous carcinomas and / or peritoneal serous carcinomas of unknown primary origin.

Shponka¹,

Poslavska²,

Savchenko³

2020

Medicni Perspektivi (Medical Perspectives)

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Реферат. Значение серозных интраэпителиальных карцином маточных труб в возникновении "highgrade" серозных карцином яичников и / или перитонеальных серозных карцином неизвестной первичной локализации. Шпонька И.С., Пославская А.В., Савченко О.А. Исследования последних десятилетий серозных аденокарцином малого таза женщин ставили перед собой цель различить две диагностические единицы: "low-grade" и "high-grade" карцином. Предшественником "low-grade" варианта (тип I) считается пограничная серозная опухоль / атипичная пролиферирующая серозная опухоль (serous borderline tumor / atypical proliferative serous tumor-8442/1), что по Международной классификации онкологических болезней (International Classification of Diseases for Oncology ICD-O 2013) репродуктивной системы женщин относится к неспецифическим, пограничным опухолям и опухолям с непредсказуемым клиническим поведением. Предшественниками "high-grade" варианта (тип II) рассматриваются серозные тубулярные интраэпителиальные карциномы (in situ) или "high-grade" серозные инвазивные карциномы маточных труб, так как они имеют

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Section: Results Group Immunophenotypes Showed Uniformity In the Expunclassified

Importance of serous intraepithelial ovarian tubal carcinomas in the occurrence of "high-grade" serous carcinomas and / or peritoneal serous carcinomas of unknown primary origin.

Shponka¹,

Poslavska²,

Savchenko³

2020

Medicni Perspektivi (Medical Perspectives)

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“…Characteristic of a type II ovarian carcinoma is its rapid spread throughout the body. HG-SOC cells usually originate in the fallopian tube, but may be primarily ovarian or peritoneal in a final metastatic location [ 19 ]. Its aggressive nature is supported by the fact that HG-SOC is responsible for 70–80% of all ovarian cancer deaths [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts

et al. 2021

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Background: We developed a fluorophore-conjugated peptide agent, SBK4, that detects a tumor-specific proteolyzed form of the cell adhesion molecule, PTPmu, found in the tumor microenvironment. We previously demonstrated its tissue specific distribution in high-grade brain tumors. To extend those studies to other aggressive solid tumor types, we assessed the tissue distribution of PTPmu/SBK4 in a set of matched gynecologic cancer patient derived xenografts (PDXs) and primary patient tumors, as well as a limited cohort of tumors from gynecological cancer patients. PDXs isolated from the tissues of cancer patients have been shown to yield experimentally manipulatable models that replicate the clinical characteristics of individual patients’ tumors. In this study, gynecological cancer PDXs and patient biopsies were examined to determine if tumor-specific proteolyzed PTPmu was present. Methods: We used the peptide agent SBK4 conjugated to the fluorophore Texas Red (TR) to label tumor tissue microarrays (TMAs) containing patient and/or PDX samples from several high-grade gynecologic cancer types, and quantified the level of staining with Image J. In one TMA, we were able to directly compare the patient and the matched PDX tissue on the same slide. Results: While normal tissue had very little SBK4-TR staining, both primary tumor tissue and PDXs have higher labeling with SBK4-TR. Matched PDXs and patient samples from high-grade endometrial and ovarian cancers demonstrated higher levels of PTPmu by staining with SBK4 than normal tissue. Conclusion: In this sample set, all PDXs and high-grade ovarian cancer samples had increased labeling by SBK4-TR compared with the normal controls. Our results indicate that proteolyzed PTPmu and its novel peptide detection agent, SBK4, allow for the visualization of tumor-specific changes in cell adhesion molecules by tissue-based staining, providing a rationale for further development as an imaging agent in aggressive solid tumors, including gynecological cancers.

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“…To understand the relationship between the aberrant p53 expression and TP53 mutation, a high-grade serous carcinoma of the female genital tract was studied as a representative cancer model [18]. This kind of malignancy almost always shows an aberrant p53 expression, consistent with that of the mutated type of the TP53 gene.…”

Section: Discussionmentioning

confidence: 99%

“…The next day, she returned to the hospital with relapse of the abdominal symptoms. The in-house radiological department noticed that the previous CT images showed an obstructed ileus arising from the nodule detected on a 18 Ffluorodeoxyglucose positron emission tomography scan 3 months ago ( Fig. 1c, d).…”

Section: Clinical Historymentioning

confidence: 99%

Metastatic colon cancer of the small intestine diagnosed using genetic analysis: a case report

et al. 2020

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Background: Intestinal-type adenocarcinoma is widely detected in the gastrointestinal tract, head and neck, lower respiratory and urinary systems. Determining the nature (monoclonal or multicentric) of the intestinal adenocarcinoma is sometimes a diagnostic challenge owing to its occurrence at various locations of the body, especially in the lower gastrointestinal tract. Herein, we successfully diagnosed metastatic colon cancer in the small intestine using tumor protein 53 gene (TP53) mutation analysis. Case presentation: An 83-year-old woman presented with severe abdominal pain and nausea at the emergency department of the hospital. Her history included surgery and adjuvant chemotherapy for colon and breast cancers. Abdominal computed tomography revealed small intestinal dilation, which was associated with the mural nodule detected on fluorodeoxyglucose positron emission tomography. Laparoscopy-assisted small bowel resection was performed based on the diagnosis of small bowel obstruction, probably due to recurrence of the colon or breast cancer. Macroscopically, an ulcerated tumor was present in the resected small intestine. Histologically, the cancer cells showed infiltrative growth of colonic dysplastic glands, whose non-specific finding made it difficult to determine the relationship with past colon cancers. Retrospective pathological examination confirmed that the previous breast and colon carcinomas were primary cancers. Immunohistochemical analysis revealed that the small intestinal and colon cancer cells showed diffuse positive tumor protein 53 (p53) expression. However, the breast cancer cells showed only weakly positive p53 expression. In addition, TP53 mutational analysis detected an identical missense mutation (p.T211I) between the two intestinal cancers. Moreover, further molecular genetic work-up revealed that both small intestinal and colon adenocarcinomas harbored an identical missense mutation (p.G12D) of KRAS gene. In conclusion, the small intestinal cancer in this case was identified as a metastatic adenocarcinoma arising from a past colon cancer. Conclusions: Genetic analyses help in clarifying the identity of the cells in multiple cancer cases. In morphologically indeterminate cases, molecular analysis of common cancer-related genes can be useful for a precise and reproducible diagnosis.

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A Comprehensive Review of Ovarian Serous Carcinoma

Cited by 47 publications

References 115 publications

Importance of serous intraepithelial ovarian tubal carcinomas in the occurrence of "high-grade" serous carcinomas and / or peritoneal serous carcinomas of unknown primary origin.

Importance of serous intraepithelial ovarian tubal carcinomas in the occurrence of "high-grade" serous carcinomas and / or peritoneal serous carcinomas of unknown primary origin.

Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts

Metastatic colon cancer of the small intestine diagnosed using genetic analysis: a case report

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