A comprehensive review of the influence of Epigallocatechin gallate on Sjögren's syndrome associated molecular regulators of exocytosis (Review)

Abstract

Sjögren's syndrome (SS) is an autoimmune disorder that affects the salivary glands, leading to reduced secretory functions and oral and ocular dryness. The salivary glands are composed of acinar cells that are responsible for the secretion and production of secretory granules, which contain salivary components, such as amylase, mucins and immunoglobulins. This secretion process involves secretory vesicle trafficking, docking, priming and membrane fusion. A failure during any of the steps in exocytosis in the salivary glands results in the altered secretion of saliva. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors, actin, tight junctions and aquaporin 5 all serve an important role in the trafficking regulation of secretory vesicles in the secretion of saliva via exocytosis. Alterations in the expression and distribution of these selected proteins leads to salivary gland dysfunction, including SS. Several studies have demonstrated that green tea polyphenols, most notably Epigallocatechin gallate (EGCG), possess both anti-inflammatory and anti-apoptotic properties in normal human cells. Molecular, cellular and animal studies have indicated that EGCG can provide protective effects against autoimmune and inflammatory reactions in salivary glands in diseases such as SS. The aim of the present article is to provide a comprehensive and up-to-date review on the possible therapeutic interactions between EGCG and the selected molecular mechanisms associated with SS.

Association between tea consumption and quality of life in men with esophageal squamous carcinoma based on TTD model

“…For the EORTC QLQ-OES18 scale, the analysis found that postoperative tea consumption improved signi cantly on eating problems, odynophagia, trouble swallowing saliva, coughing and speech problems. The main mechanism may be through the antioxidant and anti-in ammatory effects of Ltheanine (Chen et al 2022a) and epigallocatechin (Errachid et al 2021) components in tea to achieve improve pain and maintain a stable oral environment. This suggests that cancer patients may improve their oral environment and thus symptoms such as di culty eating, dry mouth, cough and swallowing by drinking tea.…”

Improvement of postoperative quality of life in patients with esophageal squamous cell carcinoma: does tea consumption have a role?

“…For the EORTC QLQ-OES18 scale, the analysis found that postoperative tea consumption improved significantly on eating problems, odynophagia, trouble swallowing saliva, coughing and speech problems. The main mechanism may be through the antioxidant and antiinflammatory effects of L-theanine [24] and epigallocatechin [25] components in tea to achieve improve pain and maintain a stable oral environment. This suggests that cancer patients may improve their oral environment and thus symptoms such as difficulty eating, dry mouth, cough and swallowing by drinking tea.…”

Primary Sjögren’s syndrome: new perspectives on salivary gland epithelial cells

“…The stimulation of β1-adrenergic receptor induces exocytosis of protein storage granules via the cAMP/PKA pathway [ 38 ]. During exocytosis, SNARE proteins play a crucial role in membrane trafficking and fusion [ 48 ]. Mucins, primarily MUC5B and MUC7 in human saliva, are the major proteins released through exocytosis [ 49 ].…”