A comprehensive review on phytochemistry, bioactivity and medicinal value of bioactive compounds of pomegranate (Punica granatum)

Ranjha, Muhammad Modassar Ali Nawaz; Shafique, Bakhtawar; Wang, Lufeng; Irfan, Shafeeqa; Safdar, Muhammad; Murtaza, Mian Anjum; Nadeem, Muhammad; Mahmood, Shahıd; Mueen-ud-Din, Ghulam; Nadeem, Hafiz Rehan

doi:10.1007/s13596-021-00566-7

Cited by 52 publications

(33 citation statements)

References 101 publications

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“…In addition, different studies demonstrate the antimicrobial and antioxidant effect of various pomegranate extracts and report the isolation of various compounds responsible for P. granatum bioactivities [ 8 , 47 ]. Compounds like anthocyanin, caffeic acid, catechin, chlorogenic acid, cinnamic acid, coniferyl, coumaric acid, cyanidin, delphinidin, ellagic acid, flavonoids, gallic acid, genistein, kaempferol, linoleic acid, luteolin, pelletierine alkaloids, punicalin, punicalagin, quercetin, rutin, sinapyl, and tannin are responsible for significant antidiabetic, antihypertensive, antioxidant, antimicrobial, and other biological activities of pomegranate fruit [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Study of the Antibacterial Activity of Bioactive Juice and Extracts from Pomegranate (Punica granatum L.) Peels and Seeds

Kupnik

Primožič

Vasić

et al. 2021

Plants

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Due to the growing awareness of Punica granatum fruit’s health-promoting properties, the pomegranate is increasingly used for food purposes. This results in the formation of biological waste products such as peels. A biowaste circular bioeconomy strategy holds great prospective for a sustainable economy. Therefore, a sustainable and environmentally friendly way of disposing of waste (e.g., use of biowaste to obtain high-value components (e.g., punicalagins, enzymes)) is crucial for the protection of the environment and human health. In the presented study, the content of total phenols and proanthocyanidins in ten samples of Punica granatum fruit (juice, aqueous (H2O) and ethanolic (EtOH) extracts of peels and seeds) was determined. Peel extracts were found to be the richest in the content of secondary metabolites and showed extremely high antioxidant potential (approximately 90% inhibition: DPPH radical scavenging activity). To the best of our knowledge, this is the first comparative study to determine the enzymatic activity of α-amylase, lipase, peroxidase, protease, and transglutaminase in different P. granatum samples. Furthermore, the antibacterial efficacy of all P. granatum samples was qualitatively determined against three strains of Gram-negative (Escherichia coli, Pseudomonas aeruginosa, and Pseudomonas fluorescens) and three strains of Gram-positive (Bacillus cereus, Staphylococcus aureus, and Streptococcus pyogenes) bacteria, susceptible to gaining antibiotic resistance. Moreover, the most promising peel extracts were quantified for antibacterial efficacy against tested bacteria at five different concentrations. All samples slowed down and inhibited the growth of all tested bacteria. MIC90 values (2.7 or 0.3 mg/mL) were determined in 18 out of 24 experiments (four samples, six bacteria tested). There is no research in the reviewed literature that is current with such detailed and comprehensive determination of P. granatum peel extracts antibacterial activity. The results of the research showed great potential for the use of P. granatum in the field of antibacterial activity in biomedicine applications and in the cosmetic, food, and pharmaceutical industries.

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Section: Discussionmentioning

confidence: 99%

A Comprehensive Study of the Antibacterial Activity of Bioactive Juice and Extracts from Pomegranate (Punica granatum L.) Peels and Seeds

Kupnik

Primožič

Vasić

et al. 2021

Plants

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“…Phytochemistry explains that there are more secondary metabolites available in the plants [35][36][37][38][39]. Various techniques are applied to extract bioactive compounds such as flavonoids, phenolic acids, keratin, tanshinone, terpenoids, tocols, xanthones, carrageenans, a-mangostin, isoflavones, apigenin, genistin and many others [40][41][42][43].…”

Section: Extraction Of Bioactive Compoundsmentioning

confidence: 99%

Sonication, a Potential Technique for Extraction of Phytoconstituents: A Systematic Review

et al. 2021

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Traditional extraction techniques have lost their optimum performance because of rising consumer demand and novel technologies. In this regard, several techniques were developed by humans for the extraction of plant materials from various indigenous sources, which are no longer in use. Many of the techniques are not efficient enough to extract maximum plant material. By this time, evolution in extraction has led to development of various techniques including microfiltration, pulsed electric fields, high pressure, microwave assistance, enzyme assistance, supercritical fluid, subcritical fluid and ultrasonication. These innovations in food processing/extraction are known as “Green Food Processing”. These technologies were basically developed by focusing on three universal parameters: simplicity, energy efficiency and economy. These green technologies are practical in a number of different food sectors, mostly for preservation, inhibition of microorganisms, inactivation of enzymes and extraction of plant material. Like the others, ultrasonication could also be used for the said purposes. The primary objective of this review is to confine the potential use of ultrasonication for extraction of oils, pectin and phytochemicals by reviewing the literature systematically.

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“…The flower also contained daucosterol, a sterol, and Punic flavone, a flavonoid 81 . It was known that cinnamic acid has an anti-obese effect 82 . A study was performed to assess the effects of obesity with the consumption of pomegranate peel extract.…”

Section: Pomegranate Teamentioning

confidence: 99%

Evaluation of the Slimming Effects of Diet Tea in Biochemical and Molecular Meaning

Eyüpoğlu

Arman

2021

Univ J Pharm Res

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The replacement of consumed with foods containing high carbohydrates, fats and proteins exceed that the daily needs of body, causes many health problems, especially obesity. Complicated health problems have been trying to be solved with drugs, but it is not possible to control diseases if obesity is not resolved. Obesity causes inflammation, insulin resistance, vascular endothelial dysfunction, and Low-Density Lipoprotein (LDL) increase. There are very few weight loss drugs with acceptable side effects, and these drugs are not given to people who are not considered obese according to their body mass index. For this reason, people seek the remedy in over the counter (OTC) (mostly products with active ingredients derived from plants) products or herbal teas. These products, which do not have direct effects, have mechanisms that can help and can be supportive with diet and sports. However, these products and teas that cannot be dosed by a knowledgeable healthcare professional can disrupt the balance of the body and cause various diseases. In this study, the effect levels with the mechanisms supporting weight loss on the biochemical parameters of the active substances in the herbal forms sold and consumed as diet tea, were evaluated. Peer Review History: Received: 4 July 2021; Revised: 11 August; Accepted: 6 September, Available online: 15 September 2021 Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 6.0/10 Average Peer review marks at publication stage: 7.5/10 Reviewers: Dr. Gehan Fawzy Abdel Raoof Kandeel, Pharmacognosy Department, National Research Centre, Dokki, 12622, Giza, Egypt, gehankandeel9@yahoo.com Dr. Marwa A. A. Fayed, University of Sadat City, Egypt, maafayed@gmail.com

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A comprehensive review on phytochemistry, bioactivity and medicinal value of bioactive compounds of pomegranate (Punica granatum)

Cited by 52 publications

References 101 publications

A Comprehensive Study of the Antibacterial Activity of Bioactive Juice and Extracts from Pomegranate (Punica granatum L.) Peels and Seeds

A Comprehensive Study of the Antibacterial Activity of Bioactive Juice and Extracts from Pomegranate (Punica granatum L.) Peels and Seeds

Sonication, a Potential Technique for Extraction of Phytoconstituents: A Systematic Review

Evaluation of the Slimming Effects of Diet Tea in Biochemical and Molecular Meaning

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