A Comprehensive Review on the Anti-Cancer Effects of Oleuropein

Abstract

In Mediterranean cuisine and culture, olive oil and olive fruits play a significant role. Many people believe that those who consume olive oil and its fruit live longer and have a decreased risk of illness. Olive leaves were used to treat a range of diseases in ancient times, including malaria fever and lower earaches. Although it was not understood at the time what key components were responsible for these effects because they had not yet been discovered, Oleuropein is now recognized as one of the primary elements in immature olive fruits and leaves. Later research was carried out to determine the effects of this molecule, and it was determined that it functions as an antioxidant. Oleuropein consumption has aided in cancer treatment over the years, and this was assumed to be owing to its antioxidant properties. Oleuropein’s effects on cancer, however, go beyond that; it is now known that Oleuropein functions as both an anti-proliferative and an apoptotic promoter in many cancer cells. The kinetics and dosages of Oleuropein and the mechanisms behind its involvement and effects in cancer are explored in this review. Finally, the effects of Oleuropein in combination with anticancer medicines are investigated.

The impact of oleuropein on miRNAs regulating cell death signaling pathway in human cervical cancer cells

“…25 Some research works have shown that oleuropein has apoptotic effects in different cancer cell lines. 26 Vizza et al reported that the extract obtained from olive leaf, which is rich in polyphenols, induced apoptosis in the HeLa cells due to an increased expression of p21. 27 On…”

“…Some research works have shown that oleuropein has apoptotic effects in different cancer cell lines 26 . Vizza et al.…”

Olea europaea Leaf Phenolics Oleuropein, Hydroxytyrosol, Tyrosol, and Rutin Induce Apoptosis and Additionally Affect Temozolomide against Glioblastoma: In Particular, Oleuropein Inhibits Spheroid Growth by Attenuating Stem-like Cell Phenotype

“…OL is recognized as the most abundant phenolic of OLE [ 37 ]. The anticancer effect of OL as an antiproliferative and an apoptosis promoter was previously demonstrated in multiple cancer types, such as breast and colon cancer cell lines [ 38 , 39 , 40 , 41 ]. Additionally, our previous study showed that an equal concentration of OL-only from a predetermined amount of OLE (15%) demonstrated an anticancer effect in T98G cells [ 17 ].…”

Development of Pegylated Nano‐Phytosome Formulation with Oleuropein and Rutin to Compare Anti‐Colonic Cancer Activity with Olea Europaea Leaves Extract

“…Oleuropein (Oleu) is the principal phenolic component present in olive leaves, in addition to other essential components, i. e., rutin, catechin, tyrosol, and caffeic acid [9,10] . Oleu has a wide range of anti‐inflammatory, anti‐microbic, antioxidant, and immunomodulatory activities [11] . A number of studies have shown that the consumption of Oleu decreases cancer incidence, especially in the stomach, breast, and colorectal cancer, due to its antioxidant property [12] .…”

“…[9,10] Oleu has a wide range of anti-inflammatory, anti-microbic, antioxidant, and immunomodulatory activities. [11] A number of studies have shown that the consumption of Oleu decreases cancer incidence, especially in the stomach, breast, and colorectal cancer, due to its antioxidant property. [12] However, recent studies have shown that the effects of Oleu on cancer go beyond that, where it acts as a both anti-proliferative and apoptotic promoter in a number of cancer cells.…”