A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics

Pattnaik, Lolly; Acharya, Laxmikanta

doi:10.1016/j.lfs.2015.01.040

Cited by 26 publications

(22 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ocular allergy is a common disease in daily practice. VKC could be idiopathic or associated with underlying etiologies including but not limited to immune disease, endocrine, genetic, neurogenic, and environmental (1,2) . Autoimmune Polyglandular Syndrome type II (APS-2) is the most frequent Autoimmune Polyglandular Syndrome.…”

Section: Discussionmentioning

confidence: 99%

Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Alhawari¹,

Bdour²

2016

JMJ

View full text Add to dashboard Cite

Vernal keratoconjunctivitis (VKC) is a bilateral, usually seasonally recurrent inflammation of the conjunctiva. Even though it is an uncommon type of allergic eye disease but in some cases it can cause severe damage to the ocular surface, leading to keratoconus (KC) and vision loss. We report a rare case of vernal keratoconjunctivitis and keratoconus diagnosed since childhood and then was diagnosed years later with Addison's disease and subclinical hypothyroidism. Even though the association between VKC and autoimmune diseases is still not clear but this case highlights the importance of having a low threshold to screen patients with VKC for autoimmune diseases based on their clinical presentation.

show abstract

Section: Discussionmentioning

confidence: 99%

Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Alhawari¹,

Bdour²

2016

JMJ

View full text Add to dashboard Cite

show abstract

“…Though it should be noted that these presentations are similar to other forms of allergic conjunctivitis and, within VKC, these symptoms may vary from patient-to-patient [50]. Therefore, objective tools may be necessary to confirm a VKC diagnosis.…”

Section: Ocular Allergiesmentioning

confidence: 99%

Biomarkers of Ocular Surface Disease Using Impression Cytology

Hagan

2017

Biomark. Med.

View full text Add to dashboard Cite

Impression cytology (IC) is a technique which permits the retrieval of the outermost layer of ocular surface cells via the use of various types of filters. It is a minimally invasive method of evaluating human conjunctival epithelial cell morphology in the diagnosis of dry eye disease, a common and distressing disorder associated with ageing, contact lens wear, autoimmune disorders and refractive (LASIK) surgery. IC may also be utilized in the diagnosis of other ocular diseases, such as keratoconus and thyroid orbitopathy. More recently, IC has been utilized for the subsequent investigation of gene and protein expression of conjunctival cells in order to identify novel diagnostic biomarkers and to further our understanding of the mechanisms underlying ocular surface disease. This review will therefore examine the literature concerning the role of IC in identifying cellular markers of eye disease, systemic diseases with ocular involvement and potential novel therapeutic targets. Impression cytology (IC) is a minimally invasive method of evaluating human ocular surface cells and is considered as the 'gold standard' technique for assessing cell morphology. Introduced by Thatcher et al. [1] and Egbert et al. [2], IC is an easy-to-use technique of directly retrieving (mainly conjunctival) cells, using various filter types which are gently applied to exposed (interpalpebral) conjunctival surfaces. The filters used include cellulose acetate [3], polycarbonate (Biopore, Millipore UK Ltd, Watford, UK) [4], nitrocellulose [5] or polyethersulfone (PES) [6] which are gently applied to exposed (interpalpebral) conjunctival surfaces. Recently, a more standardized tool for IC sampling has been introduced (Figures 1 & 2). The Eyeprim is a new single-use PES filter sampling medical device for retrieval of conjunctival cells (Opia Technologies, France) and a recent study by Lopez-Miguel et al. [7] performed an analysis of this tool versus the traditional IC method (PES). On a cohort of 20 healthy individuals, they extracted and compared RNA from both devices and found no significant differences in the mean yield (p ≥ 0.45), the total RNA amount (μg), or the amount normalized to membrane area [7]. Although an earlier study of the Eyeprim [8], suggested that it recovered more cells than traditional IC, Lopez-Miguel et al. [7] did not observe differences in the RNA collected between this device and PES.Historically, IC has been used to analyze pathological changes to conjunctival cells for indicators of squamous metaplasia in ocular surface disease (OSD) [9]. More recently, however, researchers have used IC to examine specific markers of inflammation, for example, HLA-DR, ICAM-1 and CD8 [10][11][12], and to examine novel biomarkers of dry eye disease (DED). The latter is performed in an attempt to understand the mechanisms underpinning DED pathophysiology and is now feasible, due to vast improvements in the assay sensitivities for gene and protein examination [13]. As a result, IC membranes can be subsequently analyzed using techniq...

show abstract

“…18 In addition to excluding patients diagnosed with vernal conjunctivitis based on the ICD-9 code, we excluded disorders commonly associated with VKC, including such as asthma, keratoconus, gynaecomastia, polycystic ovary syndrome, mammary fibroadenoma, adipogenital dystrophy, autoimmune thyroid disease, systemic lupus erythematosus, rheumatoid arthritis and Sjögren syndrome. 18 After the exclusion of patients with AKC and VKC who may have been at higher risk of developing an autoimmune disease, our study revealed that individuals with T1DM are at a significantly higher risk of developing AC than individuals who do not suffer from diabetes. Several potential explanations must be considered.…”

Section: Open Accessmentioning

confidence: 99%

Risk of allergic conjunctivitis in patients with type 1 diabetes mellitus: a population-based retrospective cohort study

et al. 2017

View full text Add to dashboard Cite

ObjectiveIn accordance with the dichotomy between T helper type 1(Th1) and T helper type 2 (Th2) responses, the occurrence of allergic conjunctivitis (AC) and type 1 diabetes mellitus (T1DM) is, in theory, inversely related in the individual. However, recent studies investigating the association between the two diseases are controversial.DesignPopulation-based cohort study.SettingWe used claims data of the National Health Insurance Research Database of Taiwan.ParticipantsWe identified 4160 patients aged 1–30 years with newly diagnosed T1DM and no history of AC at baseline. For each patient with T1DM, four non-T1DM controls (n=16,640) were matched by sex. The mean follow-up time was 6 years.Primary and secondary outcome measuresMultivariate Cox proportional hazards regression analysis was used to evaluate the risk of AC. We additionally evaluated the association between risk of AC and T1DM progression by examining Diabetes Complications Severity Index (aDCSI) changes from the date of diagnosis until the end of follow-up.ResultsThe overall incidence of allergic conjunctivitis (AC) was higher in the type 1 diabetes mellitus (T1DM) cohort than in the control cohort (23.0 vs 13.5 per 1000 person-years, adjusted incidence rate ratio (aIRR): 1.59, 95% CI 1.47 to 1.71). Relative to that in patients with mildly progressive T1DM, the risk of AC increased as the adapted Diabetes Complications Severity Index (aDCSI) increased (aIRR: 1.68, 3.78 and 18.8, with yearly changes in aDCSI score: 0.51 to 1.00, 1.01 to 2.00, and >2.00 vs <0.51, respectively; for trend <0.001).ConclusionPatients with T1DM are at an elevated risk of developing AC; this risk increases with T1DM progression. The T helper type 1/T helper type 2 hypothesis is an overly simplistic explanation for this association.

show abstract

A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics

Cited by 26 publications

References 71 publications

Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Vernal Keratoconjunctivitis and Severe Keratoconus Associated with Autoimmune Polyglandular Syndrome Type II ( APS-2 ) : A Case Report

Biomarkers of Ocular Surface Disease Using Impression Cytology

Risk of allergic conjunctivitis in patients with type 1 diabetes mellitus: a population-based retrospective cohort study

Contact Info

Product

Resources

About