A comprehensive study of the resistance to biofouling of different polymers for optical oxygen sensors. The advantage of the novel fluorinated composite based on core-dye-shell structure

Alexandrovskaya, A. Yu.; Melnikov, Petr; Safonov, Alexey; Naumova, Alina O.; Zaytsev, N. K.

doi:10.1016/j.mtcomm.2020.100916

Cited by 13 publications

(18 citation statements)

References 33 publications

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“…The temperature affects the fluorescence intensity of the indicator and thus the sensitivity of the sensing film [ 38 , 39 , 40 ]; however, most previous studies were carried out at room temperature. In order to investigate the effect of temperature on the sensing performance of the sensing films, we measured the phase delay variations of the sensing films with different types of the polymer matrices in the constant temperature trough ( Figure 2 ), from 10 °C to 50 °C (with an increment of 10 °C).…”

Section: Resultsmentioning

confidence: 99%

Tuning the Sensitivity and Dynamic Range of Optical Oxygen Sensing Films by Blending Various Polymer Matrices

Zhang

et al. 2021

Biosensors

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In this work, eight different types of optical oxygen sensing films were prepared by impregnating indicator and matrix solution on the surface of a polypropylene microporous filter membrane. The polymer matrix of the sensing films was ethyl cellulose (EC), polymethyl methacrylate (PMMA), and their blends with different mixing ratios. Scanning electron microscopy (SEM), laser confocal microscopy, and fluorescence spectrometer were used to investigate the morphologies and optical properties of the sensing films. Phase delay measurements under different oxygen partial pressures (PO2) and temperatures were applied to investigate the analytical performances of the sensing film for gaseous O2 monitoring. Results show that the response time of all the sensing films was extremely fast. The sensitivities and dynamic ranges of the sensing films with the blended polymer matrix were separately decreased and increased as the EC/PMMA ratio decreased, and the S-V curve of the sensing films blended with equal content of EC and PMMA exhibited good linearity under different temperatures, showing a promising prospect in practical application.

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Section: Resultsmentioning

confidence: 99%

Tuning the Sensitivity and Dynamic Range of Optical Oxygen Sensing Films by Blending Various Polymer Matrices

Zhang

et al. 2021

Biosensors

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“…The latter was represented by the complex of Pt (II) 5,10,15,20-tetrakis (2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP, Frontier Scientific, www.frontiersci.com (accessed on 4 October 2021)), which is widely used both in commercial oxygen analyzers and in scientific research [27]. The second phase is represented by the fluorine-containing polymer, fluoroplastic 42 (F42, HaloPolymer, www.halopolymer.ru (accessed on 4 October 2021)), which serves as the media for microparticles distribution and protects the sensor from both dye leaching even in an environment containing hydrocarbons and from biological fouling [28,29]. A similar approach could be used in sensors for other substances [30].…”

Section: Methodsmentioning

confidence: 99%

Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design

et al. 2021

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The development of different methods for tuning surface properties is currently of great interest. The presented work is devoted to the use of modified nanodiamonds to control the wetting and biological fouling of polymers using optical sensors as an example. We have shown that, depending on the type of modification and the amount of nanodiamonds, the surface of the same fluorinated polymer can have both bactericidal properties and, on the contrary, good adhesion to the biomaterial. The precise control of wetting and biofouling properties of the surface was achieved by the optimization of the modified nanodiamonds thermal anchoring conditions. In vitro and in vivo tests have shown that the fixation of amine functional groups leads to inhibition of biological activity, while the presence of a large number of polar groups of mixed composition (amide and acid chloride) promotes adhesion of the biomaterial and allows one to create a biosensor on-site. A comprehensive study made it possible to establish that in the first 5 days the observed biosensor response is provided by cells adhered to the surface due to the cell wall interaction. On the 7th day, the cells are fixed by means of the polysaccharide matrix, which provides much better retention on the surface and a noticeably greater response to substrate injections. Nevertheless, it is important to note that even 1.5 h of incubation is sufficient for the formation of the reliable bioreceptor on the surface with the modified nanodiamonds. The approach demonstrated in this work makes it possible to easily and quickly isolate the microbiome on the surface of the sensor and perform the necessary studies of its substrate specificity or resistance to toxic effects.

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“…The effects can be reduced by using a suitable sensor matrix or coatings and placing the sensing element away from the cells. 107 The photodegradation of the sensor dyes can be an additional limiting factor for long-term stability. Sensor dyes with low photostability degrade upon interaction with light and lose their brightness.…”

Section: Integration Of Sensors–miniaturizationmentioning

confidence: 99%

“…Biofouling also occurs in optical sensors from the interaction with cell media. The effects can be reduced by using a suitable sensor matrix or coatings and placing the sensing element away from the cells . The photodegradation of the sensor dyes can be an additional limiting factor for long-term stability.…”

Section: Integration Of Sensors–miniaturizationmentioning

confidence: 99%

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

Fuchs

Johansson

Tjell

et al. 2021

ACS Biomater. Sci. Eng.

134

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Organ-on-chip systems are promising new in vitro research tools in medical, pharmaceutical, and biological research. Their main benefit, compared to standard cell culture platforms, lies in the improved in vivo resemblance of the cell culture environment. A critical aspect of these systems is the ability to monitor both the cell culture conditions and biological responses of the cultured cells, such as proliferation and differentiation rates, release of signaling molecules, and metabolic activity. Today, this is mostly done using microscopy techniques and off-chip analytical techniques and assays. Integrating in situ analysis methods on-chip enables improved time resolution, continuous measurements, and a faster read-out; hence, more information can be obtained from the developed organ and disease models. Integrated electrical, electrochemical, and optical sensors have been developed and used for chemical analysis in lab-on-a-chip systems for many years, and recently some of these sensing principles have started to find use in organ-on-chip systems as well. This perspective review describes the basic sensing principles, sensor fabrication, and sensor integration in organ-on-chip systems. The review also presents the current state of the art of integrated sensors and discusses future potential. We bring a technological perspective, with the aim of introducing in-line sensing and its promise to advance organ-on-chip systems and the challenges that lie in the integration to researchers without expertise in sensor technology.

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A comprehensive study of the resistance to biofouling of different polymers for optical oxygen sensors. The advantage of the novel fluorinated composite based on core-dye-shell structure

Cited by 13 publications

References 33 publications

Tuning the Sensitivity and Dynamic Range of Optical Oxygen Sensing Films by Blending Various Polymer Matrices

Tuning the Sensitivity and Dynamic Range of Optical Oxygen Sensing Films by Blending Various Polymer Matrices

Modified Nanodiamonds as a Means of Polymer Surface Functionalization. From Fouling Suppression to Biosensor Design

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

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