A total of 52 patients with symptomatic talar OCD stage I and II were included in a clinical follow-up study. Time needed for preparation, including the placement of the DRB, scanning time, and preparation of the trajectories was 7 min 32 s (4-30 min). In 50 cases (96%), the drilling was judged with 3D imaging to be correct. In the remaining 2 cases (4%), the drilling ended in the caudal portion of the lesion. A perforation of the cartilage was not registered arthroscopically. Follow-up after 12 months (range 6-36 months) was possible in 48 patients (92%). Three patients (6%) had been converted to bone cartilage transplantation (OATS) due to recurrent symptoms. These patients were excluded from follow-up. The follow-up scores were Visual Analogue Scale Foot and Ankle (mean 93 points [range 86-100 points]) and the SF 36 (standardized to 100 point maximum, 90 points [range 79-100 points]).