A conductive PEDOT/alginate porous scaffold as a platform to modulate the biological behaviors of brown adipose-derived stem cells

Yang, Boguang; Yao, Fanglian; Ye, Lei; Hao, Tong; Zhang, Yabin; Zhang, Lei; Dong, Dianyu; Fang, Wancai; Wang, Yan; Zhang, Xiaoyang; Wang, Changyong; Li, Junjie

doi:10.1039/c9bm02012h

Cited by 48 publications

(34 citation statements)

References 51 publications

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“…16 Crystallised scaffolds demonstrated a significant increase in water intake when compared with uncrystallised scaffolds (up to 85 times their dry weight, Fig. 2C), which is remarkably higher when compared to 3D PEDO-alginate hydrogels currently reported 12 and which we postulate as being a direct effect of the significant increase in porosity, volume and pore size. The efficacy of GOPS crosslinking was not compromised by the crystallisation treatment.…”

Section: Biomaterials Science Papermentioning

confidence: 64%

“…Most works report the fabrication of electrically conductive hydrogels or porous structures; however, all rely on the combination of the CPs with a supporting matrix. 12,25 Here we discovered that the sulphuric crystallisation yielded a profound increase in conductivity, of approximately 500-fold for the isotropic scaffolds, while the aligned scaffolds went even further with a conductivity increase in the order of 4000and 5000-fold for the transversal and the longitudinal directions, respectively (Fig. 5C and Table 1).…”

Section: Biomaterials Science Papermentioning

confidence: 71%

“…First, the combination of the electroconductive compound within a bulk matrix, with one example, whereby EDOT was polymerised in the presence of alginate to achieve porous PEDOT alginate scaffolds with conductivity in the order of S m −1 . 12 Second, via chemically crosslinking of PEDOT:PSS slurries with crosslinking agents such as glycidoxypropyltrimethoxysilane (GOPS). 10,13 The latter approach poses drawbacks in that a rather brittle structure is attained which at the same time compromises the overall conductivity of the scaffold.…”

Section: Introductionmentioning

confidence: 99%

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Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications

Solazzo

Monaghan

2021

Biomater. Sci.

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Section: Biomaterials Science Papermentioning

confidence: 64%

Section: Biomaterials Science Papermentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications

Solazzo

Monaghan

2021

Biomater. Sci.

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“…Thus, the PEDOT network can be stabilized on the PAA molecular chain. [ 47 ] At the same time, the carboxyl group (COO − ) of PAA can also produce hydrogen bonding with PEDOT, [ 48,49 ] which can also improve the interaction between PEDOT and PAA network. The reaction chemical formula of oxidation polymerization of EDOT initiated by APS is shown in Figure S1, Supporting Information.…”

Section: Resultsmentioning

confidence: 99%

A High Strength Hydrogel with a Core–Shell Structure Simultaneously Serving as Strain Sensor and Solar Water Evaporator

Peng

Tang

Wang

et al. 2021

Macro Materials & Eng

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A super‐strong poly (acrylic acid)‐ poly(3,4‐ethylene dioxythiophene) (PAA‐PEDOT) hydrogel with a unique core‐shell structure is successfully constructed and studied. The shell composed of the conductive polymer PEDOT makes the composite hydrogel possess mechanical strength, electrical conductivity, and photothermal conversion properties, while the PAA hydrogel core ensures the flexibility, recovery, and water absorption of the composite hydrogel. The prepared PAA‐PEDOT hydrogel displays outstanding tensile strength (up to 780 KPa) and satisfactory conductivity (6.6 S m−1). Notably, the flexible strain sensor made of PAA‐PEDOT composite hydrogel presents both high sensitivity (gauge factor up to 8.87) and short response time (<200 ms), demonstrating that the composite hydrogel can accurately and timely detect the movement of human joints. In addition, PAA‐PEDOT composite hydrogel also has excellent photothermal conversion properties and can be used as a highly efficient solar water evaporator, which has a water evaporation efficiency of up to 3.05 kg m−2 h and an excellent photothermal conversion efficiency of 95% under 1‐sun irradiation (1kW m−2). These features make the composite hydrogel has great potential in many fields such as motion sensing, seawater desalination, and wastewater treatment.

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“…Electrochemistry could provide the means to accomplish this goal. Conducting polymers, for instance, are excellent building blocks for the creation of electrically responsive hydrogels (Zhang et al, 2019;Yang et al, 2020), although improvements in conductivity are desired to achieve highly sensitive cell sensing. Alternatively, the integration of hydrogels with conductive nanomaterials could overcome those limitations (Li et al, 2018).…”

Section: Summary and Future Perspectivesmentioning

confidence: 99%

Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment

Saffioti

Cavalcanti‐Adam

Pallarola

2020

Front. Bioeng. Biotechnol.

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Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and are crucial for most cellular functions. Understanding the mechanism underlying this complex interplay at the cell-matrix interface is of fundamental value to decipher key biochemical and mechanical factors regulating cell fate. The combination of material science and surface chemistry aided in the creation of controllable environments to study cell mechanosensing and mechanotransduction. Biologically inspired materials tailored with specific bioactive molecules, desired physical properties and tunable topography have emerged as suitable tools to study cell behavior. Among these materials, synthetic cell interfaces with built-in sensing capabilities are highly advantageous to measure biophysical and biochemical interaction between cells and their environment. In this review, we discuss the design of micro and nanostructured biomaterials engineered not only to mimic the structure, properties, and function of the cellular microenvironment, but also to obtain quantitative information on how cells sense and probe specific adhesive cues from the extracellular domain. This type of responsive biointerfaces provides a readout of mechanics, biochemistry, and electrical activity in real time allowing observation of cellular processes with molecular specificity. Specifically designed sensors based on advanced optical and electrochemical readout are discussed. We further provide an insight into the emerging role of multifunctional micro and nanosensors to control and monitor cell functions by means of material design.

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A conductive PEDOT/alginate porous scaffold as a platform to modulate the biological behaviors of brown adipose-derived stem cells

Abstract: The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering.

Cited by 48 publications

References 51 publications

Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications

Structural crystallisation of crosslinked 3D PEDOT:PSS anisotropic porous biomaterials to generate highly conductive platforms for tissue engineering applications

A High Strength Hydrogel with a Core–Shell Structure Simultaneously Serving as Strain Sensor and Solar Water Evaporator

Biosensors for Studies on Adhesion-Mediated Cellular Responses to Their Microenvironment

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