A conductive photothermal non-swelling nanocomposite hydrogel patch accelerating bone defect repair

Abstract

Bone defect repair is one of the most common issue in clinic. Developmental multifunctional scaffolds have become a promising strategy to effectively promote bone defect repair. Here, a series of...

Progress in Gelatin as Biomaterial for Tissue Engineering

“…Despite the fact that gelatin is not a conductive material, it has also been part of conductive hydrogels. As it is a naturally derived material, it confers highly desirable improvements in electrically active elements such as biocompatibility or cell adhesion, which otherwise are lacking in these hydrogels [77,78]. For instance, Hu et al designed a conductive hydrogel for peripheral nerve reconstruction.…”

Carbon-based electrically conductive materials for bone repair and regeneration

“…Hyaluronic acid-chitosan with simvastatin 102 Biocompatible and bioactive 3D scaffold with improved osteogenic properties 102 GO rGO coated collagen scaffolds 103 Enhanced mechanical properties, good biocompatibility, and proliferation of human bone marrow-derived mesenchymal stem cells (hBMSCs), and increased bone formation after implantation into cranial bone defects in an animal model 103 rGO Graphene hydrogel membrane 104 Guided bone tissue regeneration in a rat calvarial model, diffusion of proteins and nutrients, and promotion of early osteogenesis and mineralization to induce mature bone formation in vivo 104 Gelatin methacrylate, acryloyl-b-cyclodextrin, and b-cyclodextrin-functionalized rGO nanocomposite hydrogel patch 105 Improved mechanical strength, increased conductivity, good biocompatibility, promotion of cell proliferation and osteogenic differentiation, and enhanced in vivo bone defect repair in a rat skull model 105 Vascularized GO-collagen chamber model 106 Improved bone regeneration in vivo, osteoinductive properties and anti-fibrosis effects in an animal model, and improved angiogenic, mineralization and osteogenic differentiation of BMSCs 106 GO-modified silk fibroin/nanohydroxyapatite scaffold loaded with urine-derived stem cells (SCs) 107 Immunomodulation and promotion of bone regeneration in vivo, and enhanced mechanical properties 107 Polylactic acid (PLA)/GO nanocomposite 3D scaffolds 108 Enhanced mechanical properties, good biocompatibility and promotion of cell proliferation and mineralization 108 Graphene/hydroxyapatite nanoparticle composite hydrogels 109 Mechanically strong, electrically conductive, and biocompatible 109 Collagen-rGO coated scaffolds 110 Improved mechanical properties and enhanced osteogenic capability 110 rGO-coated titanium substrates 111 Promotion of the osteogenic differentiation of hMSCs and increased calcium phosphate deposition and osteogenic potential 111 3D-printed b-tricalcium phosphate (TCP)-based scaffolds filled with a freeze-dried gelatin/rGO-magnesium-arginine matrix 112 Enhanced mechanical properties, improved cell proliferation and osteogenic differentiation 112…”

“…Human cortical and cancellous bone have electrical conductivities of 0.02 S m À1 and 0.07 S m À1 , respectively. 128 CNTs and graphene are two of the most attractive materials that are being used in scaffolds for bone repair and regeneration applications [97][98][99]103,105,107,111 as they possess very high electrical conductivities of 10 6 -10 7 S m À1 for pure CNTs and 10 8 S m À1 for pure graphene. 129 Therefore, hybrid bone scaffolds containing a low amount of CNTs or graphene can result in a conductivity that recapitulates endogenous bone.…”

The fabrication of conductive material-decorated hydrogels for tissue repair

“…1). [19][20][21][22][23] As an electrically responsive material, the conductive hydrogel is always particularly useful in the engineering of electrical-sensitive tissues such as skeletal muscles, cardiac muscles, nerves, skins, and bones by regulating the proliferation and differentiation of the related cells (such as L929 fibroblasts, 24 C2C12 myoblasts, 25 PC12 cells, 26 RSC96 Schwann cells, 27 H9c2 cardiac cells, 28 primary cardiomyocytes, 29 MC3T3-E1 cells, 30 and mesenchymal stem cells 31 ). Therefore, compared with other wound dressings, the main advantage of the conductive hydrogel dressing is that it can offer a physical environment for cell growth and tissue repair while also allowing one to realize local delivery of electronic signals at the injured wound area to actively control cell behavior for improving wound situation and accelerating wound healing.…”