A configurable IC to contol, readout, and calibrate an array of biosensors

Abstract-In this work, we showed the realization of a fullyimplantable device that integrates a microfabricated sensing platform, a coil for power and data transmission and integrated circuits. We described a device intended to test the biocompatibility of the materials used for the microfabrication. Therefore, electronics measurements for data communication and remote powering will be reported in another article [1]. To ensure biocompatibility an epoxy enhanced polyurethane membrane was used to cover the device. We proved through an in-vitro characterization that the membrane was capable to retain enzyme activity up to 35 days. After 30 days of implant in mice, in-vivo experiments proved that the membrane promotes the integration of the sensor with the surrounding tissue, as demonstrated by the low inflammation level at the implant site.

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“…Readout circuit for the pH sensor and Pt-RTD are also integrated [14]. The readout IC will be powered by the power management IC.…”

Section: Resultsmentioning

confidence: 99%

Fabrication and packaging of a fully implantable biosensor array

Baj-Rossi

Kilinc

Ghoreishizadeh

et al. 2013

2013 IEEE Biomedical Circuits and Systems Conference (BioCAS)

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“…The sample and hold (SH) circuits are used to enable DDS sharing when different voltage profiles are needed at the same time. More information about the design and simulation of the analog circuits in the readout chain can be found in [15].…”

Section: A Electrochemical Sensor Control and Readoutmentioning

confidence: 99%

Sub-mW reconfigurable interface IC for electrochemical sensing

Ghoreishizadeh

Boero

Pullini

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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Abstract-The IronIC project has the aim of developing a fully implantable and remotely powered platform for the realtime monitoring of human metabolites. In this paper we present a mixed-signal interface IC for the electrochemical sensing data acquisition chain. The IC controls and reads out up to five biomolecular sensors, by receiving commands from a standard interface to conduct chronoamperometry (CA) and cyclic voltammetry (CV). Different voltage profiles are generated by using a single fully on-chip reconfigurable waveform generator, while the measured data are digitized. The IC is realized in 0.18 µm CMOS technology. Electrical measurements show that the linear readout current range is ±1650 nA with 8-bit resolution. The cyclic voltammetry of potassium ferricyanide and the chronoamperometry of hydrogen peroxide have been successfully performed with the interface. The IC consumes 0.92 mW from 1.8 V supply voltage, making it suitable for remotely powered and implantable applications.

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“…The IC consists of a control and readout unit that can be configured, according to the received commands from the patch, to perform different types of electrochemical measurements on different sensing sites of the sensor array. The detailed description of the control and readout part of the IC are presented in [9] and [10]. An analog to digital converter is implemented in the IC to digitize the measured data.…”

Section: System Overviewmentioning

confidence: 99%

A lightweight cryptographic system for implantable biosensors

Ghoreishizadeh

Yalcin

Pullini

et al. 2014

2014 IEEE Biomedical Circuits and Systems Conference (BioCAS) Proceedings

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Abstract-This paper presents a lightweight cryptographic system integrated onto a multi-function implantable biosensor prototype. The resulting heterogeneous system provides a unique and fundamental capability by immediately encrypting and signing the sensor data upon its creation within the body. By providing these security services directly on the implantable sensor, a number of low-level attacks can be prevented. This design uses the recently standardized SHA-3 Keccak secure hash function implemented in an authenticated encryption mode. The security module consists of the DuplexSponge security core and the interface wrapper. The security core occupies only 1550 gateequivalents, which is the smallest authenticated encryption core reported to date. The circuit is fabricated using 0.18 μm CMOS technology and uses a supply voltage of 1.8 V. The simulated power consumption of the complete cryptosystem with a 500 KHz clock is below 7 μW .

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A configurable IC to contol, readout, and calibrate an array of biosensors

Cited by 9 publications

References 15 publications

Fabrication and packaging of a fully implantable biosensor array

Fabrication and packaging of a fully implantable biosensor array

Sub-mW reconfigurable interface IC for electrochemical sensing

A lightweight cryptographic system for implantable biosensors

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