A Connectomic Atlas of the Human Cerebrum—Chapter 8: The Posterior Cingulate Cortex, Medial Parietal Lobe, and Parieto-Occipital Sulcus

Baker, Cordell M; Burks, Joshua D.; Briggs, Robert G.; Conner, Andrew K.; Glenn, Chad A.; Manohar, Krishna; Milton, Camille K; Sali, Goksel; McCoy, Tressie M; Battiste, James; O’Donoghue, Daniel L.; Sughrue, Michael E.

doi:10.1093/ons/opy262

Cited by 26 publications

(23 citation statements)

References 22 publications

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“…The precuneus is located in the anterior precuneus (upper occipital lobe) and connected to the cuneiform muscle and primary visual cortex's visual region. The precuneus is divided into the 7M and precuneus visual (PCV) areas, and the PCV area is found in the anterior precuneus, posterior to the marginal ramus of the cingulate sulcus (29). Studies using fMRI have shown that the PCV area is involved in the process of recognizing emotional faces and working memory images of the face, body, and location (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study

Zhang

Peng

et al. 2021

Quant Imaging Med Surg

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Background: Neovascular glaucoma (NVG) is a secondary refractory disease with a poor prognosis, and there are few advanced studies on its pathogenesis and treatment. In this research, the fractional amplitude of low-frequency fluctuation (fALFF) technology was used in resting-state functional magnetic resonance imaging (rsfMRI) to investigate intrinsic neuron activity in the patient's brain with NVG. Methods: Sixteen patients with NVG (eight males and eight females) and 16 healthy controls (HCs) of similar age and sex were included. All patients and controls received rsfMRI scans, and the differences between the two groups in fALFF values were compared by independent sample t-test. Receiver operating characteristic (ROC) curves were used to compare fALFF values in the brain regions of NVG patients and HCs and assess accuracy. Finally, Pearson linear correlation analysis assessed the correlation between fALFF signals in brain regions and the clinical evaluation indicators of patients with NVG.Results: In patients with NVG, fALFF signal values in the right Rolandic operculum, left anterior cingulate and paracingulate gyri, and right caudate were significantly decreased. In contrast, fALFF signal values in the left precuneus were significantly higher than those recorded in the HCs. Analysis of the ROC curve for each brain region showed that the area under the ROC curve of NVG patients was large (close to 1), and the accuracy was good. In the NVG group, the hospital anxiety and depression scale (r=−0.952, P<0.001) and left best-corrected visual acuity (r=−0.802, P<0.001) had a negative linear correlation with the fALFF signal value of the right Rolandic operculum. The hospital anxiety and depression scale had a negative linear correlation with the fALFF signal value of the right caudate (r=−0.948, P<0.001).Conclusions: NVG patients showed dysfunction in several brain regions. These findings may assist in revealing the underlying neural mechanism of brain activity associated with NVG.

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Section: Discussionmentioning

confidence: 99%

Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study

Zhang

Peng

et al. 2021

Quant Imaging Med Surg

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“…Compared to that in TD children, children with ADHD−PAE had lower LGI extending into the left medial temporal cortex, similar to the findings of Mous et al (2014) , as well as in additional regions, overlapping those reported in Wolosin et al (2009) . These additional regions comprised areas of somatosensory and visuomotor integration (5 m; mirror system, PF) and default mode network regions (lateral, TPOJ, IP2; posterior, 31pd; and anterior, 32, 9 m) ( Baker et al, 2018a , c , d ). Most of these regions also showed altered LGI in the ADHD + PAE group.…”

Section: Discussionmentioning

confidence: 99%

Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure

Kilpatrick

Joshi

O’Neill

et al. 2021

Drug and Alcohol Dependence

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Background: An improved understanding of the neurodevelopmental differences between attention deficit hyperactivity disorder with and without prenatal alcohol exposure (ADHD + PAE and ADHD−PAE, respectively) is needed. Herein, we evaluated gyrification (cortical folding) in children with ADHD + PAE compared to that in children with familial ADHD−PAE and typically developing (TD) children. Methods: ADHD + PAE (n = 37), ADHD−PAE (n = 25), and TD children (n = 27), aged 8–13 years, were compared on facial morphological, neurobehavioral, and neuroimaging assessments. Local gyrification index (LGI) maps were compared between groups using general linear modelling. Relationships between LGI and clincobehavioral parameters in children with ADHD ± PAE were evaluated using multivariate partial least squares. Results: ADHD + PAE and ADHD−PAE groups showed significantly lower LGI (relative to TD) in numerous regions, overlapping in medial prefrontal, parietal, and temporo-occipital cortices (p < 0.001). However, LGI in left mid-dorsolateral prefrontal cortex was uniquely lower in the ADHD + PAE group (p < 0.001). Partial least squares analysis identified one significant latent variable (accounting for 59.3 % of the crossblock correlation, p < 0.001), reflecting a significant relationship between a profile of lower LGI in prefrontal (including left mid-dorsolateral), insular, cingulate, temporal, and parietal cortices and a clinicobehavioral profile of PAE, including a flat philtrum and upper vermillion border, lower IQ, poorer behavioral regulation scores, and greater hyperactivity/impulsivity. Conclusions: Children with ADHD + PAE uniquely demonstrate lower mid-dorsolateral LGI, with widespread lower LGI related to more severe facial dysmorphia and neurobehavioral impairments. These findings add insight into the brain bases of PAE symptoms, potentially informing more targeted ADHD treatments based on an objective differential diagnosis of ADHD + PAE vs. ADHD−PAE.

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“…Amateurs displayed greater gyrification than controls in the right medial lingual gyrus ( t = 1.88, P < 0.04, η 2 = 0.31) ( Table 4 ) ( Figure 5 ). Professionals compared to amateurs showed greater gyrification in the left supramarginal gyrus ( t = 1.84, P = 0.04, η 2 = 0.32) ( Table 5 ; Figure 4 ) and the right isthmus gyrus ( t = 2.29, P < 0.02, η 2 = 0.38) ( Table 5 ; Figure 6 ), which connects the posterior cingulate gyrus to the hippocampus, a pathway involved in the DMN ( Baker et al. , 2018 ).…”

Section: Resultsmentioning

confidence: 99%

Mapping the ‘funny bone’: neuroanatomical correlates of humor creativity in professional comedians

Brawer

Amir

2021

Social Cognitive and Affective Neuroscience

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What are the neuroanatomical correlates of expertise in a specific creative domain? Professional comedians, amateurs, and controls underwent a T1 MRI anatomical scan. Measures of cortical surface area (gyrification and sulcal depth) and thickness were extracted for each participant. Compared to controls, professional comedians had greater cortical surface area in the left inferior temporal gyrus, angular gyrus, precuneus, and right medial prefrontal cortex. These regions have been previously implicated in abstract, divergent thinking and the default-mode network. The high degree of overlap between the regions of greater surface area in professional comedians with the regions showing greater activation in the same group during comedy improvisation in our previous work (particularly the temporal regions and angular gyrus), suggests these regions may be specifically involved in humor creativity.

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A Connectomic Atlas of the Human Cerebrum—Chapter 8: The Posterior Cingulate Cortex, Medial Parietal Lobe, and Parieto-Occipital Sulcus

Cited by 26 publications

References 22 publications

Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study

Fractional amplitude of low-frequency fluctuation in patients with neovascular glaucoma: a resting-state functional magnetic resonance imaging study

Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure

Mapping the ‘funny bone’: neuroanatomical correlates of humor creativity in professional comedians

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