A contemporary approach for design and characterization of fiber-optic-cortisol sensor tailoring LMR and ZnO/PPY molecularly imprinted film

Usha, Sruthi P.; Shrivastav, Anand M.; Gupta, Banshi D.

doi:10.1016/j.bios.2016.08.040

Cited by 74 publications

(41 citation statements)

References 27 publications

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“…Refractive index (RI) sensing is a basis for many of the fiber based sensing applications, such as medical diagnostics, chemical concentration detection, and biomolecule sensing. To date, many optical fiber refractometer configurations have been studied, including a fiber grating and ring resonance [8,9,10,11,12], single mode-multimode-single mode (SMS) fiber structures [13,14], microfiber interferometers [15,16,17,18], photonic crystal fibers [19,20], surface plasmon resonance fiber sensors [21,22,23], and microstructure tapered fibers [24,25,26,27]. All the above sensing configurations are called evanescent sensors, in which the evanescent field of a waveguide extends into the sensing environment and directly interacts with it, typically resulting in a very high RI sensitivity.…”

Section: Introductionmentioning

confidence: 99%

High Sensitivity Refractometer Based on Reflective Smf-Small Diameter No Core Fiber Structure

Zhou

Kumar

et al. 2017

Sensors

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A high sensitivity refractive index sensor based on a single mode-small diameter no core fiber structure is proposed. In this structure, a small diameter no core fiber (SDNCF) used as a sensor probe, was fusion spliced to the end face of a traditional single mode fiber (SMF) and the end face of the SDNCF was coated with a thin film of gold to provide reflective light. The influence of SDNCF diameter and length on the refractive index sensitivity of the sensor has been investigated by both simulations and experiments, where results show that the diameter of SDNCF has significant influence. However, SDNCF length has limited influence on the sensitivity. Experimental results show that a sensitivity of 327 nm/RIU (refractive index unit) has been achieved for refractive indices ranging from 1.33 to 1.38, which agrees well with the simulated results with a sensitivity of 349.5 nm/RIU at refractive indices ranging from 1.33 to 1.38.

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Section: Introductionmentioning

confidence: 99%

High Sensitivity Refractometer Based on Reflective Smf-Small Diameter No Core Fiber Structure

Zhou

Kumar

et al. 2017

Sensors

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“…Modalities LOD Chen et al [13] Denaturalized bovine serum albumin (dBSA)-SPR chip 1 ng/mL Vasudev et al [39] LTCC-based microfluidic system 10 pg/mL Kämäräinen et al [40] Electrochemical immunosensor 0.6 ng/mL Dalirirada and Steckl [41] Aptamer functionalized Au nanoparticles 1 ng/mL Usha et al [20] LMR and ZnO/PPY nanocomposite of MIP 25.9 fg/mL This work…”

Section: Refmentioning

confidence: 98%

“…Chen et al [13] Denaturalized bovine serum albumin (dBSA)-SPR chip 1 ng/mL Vasudev et al [39] LTCC-based microfluidic system 10 pg/mL Kämäräinen et al [40] Electrochemical immunosensor 0.6 ng/mL Dalirirada and Steckl [41] Aptamer functionalized Au nanoparticles 1 ng/mL Usha et al [20] LMR The above table shows that the proposed sensor probes had the potential of achieving significantly finer LOD in comparison with most of the existing cortisol sensor probes based on diverse sensing techniques. Now, the practical implementation possibility of the proposed structure sensor configuration was discussed.…”

Section: Ref Modalities Lodmentioning

confidence: 99%

“…However, the fiber optic (FO) based SPR sensors have gained popularity due to its lightweight sensing configuration [18,19]. Recently, a lossy mode resonance (LMR) based fiber sensor with the ZnO nanocomposite for salivary cortisol detection was reported by Usha et al [20] with a detection limit of 25.9 fg/mL but fiber SPR sensor for cortisol detection still has a lot of scope of work. Owing to high sensitivity and performance tunability, exploring the plasmonic gratings (either pure metallic or thin metal layer with dielectric grating) for fiber optic detection of cortisol can also be a significant step in this direction.…”

Section: Introductionmentioning

confidence: 99%

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On The Application of SiO2/SiC Grating on Ag for High-Performance Fiber Optic Plasmonic Sensing of Cortisol Concentration

2020

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This paper reports on high-accuracy simulation of a grating structure based fiber optic plasmonic sensor for salivary cortisol sensing. Gratings of SiO2 and SiC (one at a time) in combination with a thin Ag layer are considered to be in direct contact with analyte medium (solutions containing different concentrations of cortisol) considering that the groove regions are also filled with analyte. The optimization of Ag layer thickness is carried out to achieve maximum power loss (PL) corresponding to cortisol concentration variation. The variation of PL (in dB) spectra with the angle of incidence (α) is the sensing mechanism of the proposed scheme. Sensing performance is extensively analyzed in terms of sensitivity, limit-of-detection (LOD) and figure-of-merit (FOM) that incorporates both the sensitivity and the width of the corresponding PL curves. While the sensitivity and FOM values are significantly large, the results also reveal that in angular interrogation mode (AIM), an average LOD of 9.9 pg/mL and 9.8 pg/mL is obtained for SiO2 and SiC-based sensor designs, respectively. When the intensity interrogation method (IIM) in place of AIM is considered, an average LOD of 22.6 fg/mL and 68.17 fg/mL is obtained for SiO2 and SiC-based sensor designs, respectively. LOD (with IIM, in particular) is considerably better than the present-state-of-art related to cortisol monitoring. Pragmatic model for possible practical implementation of sensor scheme is also discussed. The involvement of optical fiber in the proposed sensor design makes it possible to implement it as a flexible sensor or for wearable solution for cortisol detection via sweat monitoring as well as for measuring cortisol level in aquaculture tanks where concentration levels are much lower than 10 ng/mL.

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“…Although zinc oxide coatings have not been as extensively reported for the fabrication of LMR-based sensors as the previous cases, they have already been considered for the development of LMR-based biosensors. A cortisol sensor using ZnO thin film and a molecularly imprinted polymer layer (MIP) was developed on a MMF [43]. In this work, it was demonstrated that a variation of the concentration of cortisol could induce a shift above 51 nm in a LMR, providing a sensitivity of up to 12.86 nm/log (g/mL) and a LOD of 25.9 fg/mL.…”

Section: Zinc Oxidementioning

confidence: 99%

A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

Ozcáriz

Zamarreño

Arregui

2020

Sensors

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Lossy mode resonance based sensors have been extensively studied in recent years. The versatility of the lossy mode resonance phenomenon has led to the development of sensors based on different configurations that make use of a wide range of materials. The coating material is one of the key elements in the performance of a refractometer. This review paper intends to provide a global view of the wide range of coating materials available for the development of lossy mode resonance based refractometers.

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A contemporary approach for design and characterization of fiber-optic-cortisol sensor tailoring LMR and ZnO/PPY molecularly imprinted film

Cited by 74 publications

References 27 publications

High Sensitivity Refractometer Based on Reflective Smf-Small Diameter No Core Fiber Structure

High Sensitivity Refractometer Based on Reflective Smf-Small Diameter No Core Fiber Structure

On The Application of SiO2/SiC Grating on Ag for High-Performance Fiber Optic Plasmonic Sensing of Cortisol Concentration

A Comprehensive Review: Materials for the Fabrication of Optical Fiber Refractometers Based on Lossy Mode Resonance

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