A continuous stimuli-responsive system for NIR-II fluorescence/photoacoustic imaging guided photothermal/gas synergistic therapy

Zheng, Ziliang; Chen, Qi; Dai, Rong; Jia, Zhuo; Yang, Chenhua; Peng, Xianjia; Zhang, Ruiping

doi:10.1039/d0nr02543g

Cited by 52 publications

(43 citation statements)

References 42 publications

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“…[16] Despite significant progress in anticancer activity, unfortunately, most of the reported nanotheranostics still suffer from pronounced limitations, especially insufficient tumor accumulation and nonspecific biodistribution. [17,18] The tumor cells are generally known to distinguish different from normal cells. [19] Due to the disordered metabolic pathways and specific physiological mechanism of tumor, the tumor microenvironments (TME) perform unique characteristics such as acidic matrix, overproduced hydrogen peroxide (H 2 O 2 ), and hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Zheng

Jia

et al. 2021

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cancer diagnosis including higher spatial and temporal resolution than the conventional NIR-I window fluorescence imaging (650-900 nm), mainly benefiting from the simultaneously suppressed tissue auto-fluorescence, photon scattering, and background interference. [3-5] In spite of significant improvements in NIR-II FL for imaging performance, accurate and wealthy information at different tissue penetration depths and scales cannot be effectively provided by a single imaging technology. [6,7] Magnetic resonance imaging (MRI) has outstanding performance in modern clinical medicine, offering higher spatial resolution than that of NIR-II FL. [8,9] Considering the desirable features of each imaging modality, integration of NIR-II FL and MRI may accurately delineate tumor by compensating their inherent limitations. Therefore, there is an urgent demand for an efficient imaging tool to achieve precise MRI/NIR-II FL dual-modal imaging of tumors. With the rapid development of biomedical engineering and nanotechnology, a variety of multimodal nanoprobes have been developed and provide accurate location and therapeutic improvement of tumor. [10-12] To date, most research has been focused on the rational design and fabrication of an all-in-one nanotheranostic as an extremely valuable strategy with multifunctional theranostic performance. [13,14] Wang and co-workers designed a novel small-molecule dye DPP-BT, which showed a single NIR laser triggered multifunctional properties for NIR-II fluorescence/photoacoustic (PA) Multi-modality cancer diagnosis techniques based on the second near-infrared window fluorescence (NIR-II FL, 1000-1700 nm) imaging have become the focus of research attention. For such multimodality probes, how to take advantage of the tumor microenvironments (TME) characteristics to better image diseases and combine efficient therapeutics to achieve theranostics is still a big challenge. Herein, a novel TME-activated nanosystem (FMSN-MnO 2-BCQ) employing degradable silica-based nanoplatform is designed, adjusting the ratio of intratumoral hydrogen peroxide (H 2 O 2)/glutathione (GSH) for magnetic resonance imaging (MRI)/NIR-II FL imaging and selfreinforcing chemodynamic therapy (CDT). Innovative bovine serum albumin (BSA)-modified fusiform-like mesoporous silica nanoparticles (FMSN) is fabricated as a carrier for NIR-II small molecule (CQ4T) and MRI reporter MnO 2. Remarkably, the BSA modification helped to achieve the dual-functions of high biocompatibility and enhance NIR-II fluorescence. The FMSN-MnO 2-BCQ with FMSN framework featuring a stepwise degradability in tumor interior released MnO 2 and BCQ nanoparticles. Through the specific degradation of MnO 2 by the TME, the produced Mn 2+ ions are effectively exerted Fenton-like activity to generate hydroxyl radical (•OH) from endogenous H 2 O 2 to eradicate tumor cells. More importantly, the GSH depletion due to the synergistic effect of tetrasulfide bond and MnO 2 in turn induced the oxidative cytotoxicity for self-reinforcing CDT.

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Section: Introductionmentioning

confidence: 99%

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Zheng

Jia

et al. 2021

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“…For example, Ag 2 S QDs have been integrated into theranostic nanoplatforms combining fluorescence and PA imaging with PTT, [ 81 ] PTT plus computed tomography (CT), [ 52,53 ] and PTT plus gas therapy (GT). [ 82 ] For example, Tang et al. synthesized Ag 2 S QDs in human serum albumin (HSA) nanocages with precise size control for PTT with fluorescence and PA imaging guidance ( Figure a).…”

Section: Bioapplications Of Nir Ag2s Qdsmentioning

confidence: 99%

“…designed and constructed an activatable theranostic nanoplatform (Ag 2 S@M/D‐P‐RGD) by biomineralizing Bi 2 S 3 , Ag 2 S, and diallyl trisulfide (DATS) in BSA, and functionalizing the nanoparticles with 3‐azidopropylamine (N 3 (−) ). [ 82 ] As shown in Figure a, the encapsulated DATS released H 2 S gas when triggered by excess GSH in the tumor microenvironment. In addition to providing gas therapy, the released H 2 S enhanced tumor‐specific aggregation by reducing N 3 (−) to NH 2 (+) .…”

Section: Bioapplications Of Nir Ag2s Qdsmentioning

confidence: 99%

Synthesis and Bioapplications of Ag₂S Quantum Dots with Near‐Infrared Fluorescence

et al. 2021

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Quantum dots (QDs) with near‐infrared fluorescence (NIR) are an emerging class of QDs with unique capabilities owing to the deeper tissue penetrability of NIR light compared with visible light. NIR light also effectively overcomes organism autofluorescence, making NIR QDs particularly attractive in biological imaging applications for disease diagnosis. Considering latest developments, Ag2S QDs are a rising star among NIR QDs due to their excellent NIR fluorescence properties and biocompatibility. This review presents the various methods to synthesize NIR Ag2S QDs, and systematically discusses their applications in biosensing, bioimaging, and theranostics. Major challenges and future perspectives concerning the synthesis and bioapplications of NIR Ag2S QDs are discussed.

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“…Metal sulfides, such as copper sulfide (CuS), tungsten sulfide (WS 2 ), and molybdenum sulfide (MoS 2 ), have been widely used for PAI and photothermal therapy (PTT) as novel optical molecular imaging reagents [35][36][37][38][39]. Taking Cu 2-x S as an example, recent research revealed that the LSPR effect could be regulated by altering the composition ratio of Cu/S to realize the application of Cu 2-x S in NIR-II PAI.…”

Section: Metal Chalcogenides-based Nanomaterialsmentioning

confidence: 99%

Development of Second Near-Infrared Photoacoustic Imaging Agents

Zhang¹,

Ning²,

Zeng³

et al. 2021

Trends in Chemistry

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A continuous stimuli-responsive system for NIR-II fluorescence/photoacoustic imaging guided photothermal/gas synergistic therapy

Abstract: A step-by-step stimuli-response nanosystem that could be specifically activated by a “multistage rocket-like” process to improve its NIR-II/PA signals for imaging-guided photothermal/gas synergistic therapy.

Cited by 52 publications

References 42 publications

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Synthesis and Bioapplications of Ag₂S Quantum Dots with Near‐Infrared Fluorescence

Development of Second Near-Infrared Photoacoustic Imaging Agents

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A continuous stimuli-responsive system for NIR-II fluorescence/photoacoustic imaging guided photothermal/gas synergistic therapy

Abstract: A step-by-step stimuli-response nanosystem that could be specifically activated by a “multistage rocket-like” process to improve its NIR-II/PA signals for imaging-guided photothermal/gas synergistic therapy.

Cited by 52 publications

References 42 publications

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Biodegradable Silica‐Based Nanotheranostics for Precise MRI/NIR‐II Fluorescence Imaging and Self‐Reinforcing Antitumor Therapy

Synthesis and Bioapplications of Ag2S Quantum Dots with Near‐Infrared Fluorescence

Development of Second Near-Infrared Photoacoustic Imaging Agents

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Synthesis and Bioapplications of Ag₂S Quantum Dots with Near‐Infrared Fluorescence