A controlled, prospective study of neuropsychological outcomes post parathyroidectomy in primary hyperparathyroid patients

Chiang, Cherie; Andrewes, David; Anderson, Dianne; Devere, Michael; Schweitzer, Isaac; Zajac, Jeffrey D

doi:10.1111/j.1365-2265.2004.02180.x

Cited by 57 publications

(40 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, our longer follow-up showed a decline from both earlier measurements to 6-months' follow-up and therefore we conclude that depressive symptoms normalize over time. Depressed mood is one of the clinically relevant neuropsychiatric symptoms in pHPT, while the influence of calcium on depressive symptoms remains unclear (29,49 (27), who showed a good correlation between the well-established SF-36 and the original English PAS, we were able to show a good correlation for both German versions. Our data emphasize that its administration before and immediately after PTx yields reliable insights into specific changes and that longterm follow-up might not be required as the data did not subsequently change.…”

Section: Discussionsupporting

confidence: 50%

“…However, other studies found no evidence of a positive change in depression scales when comparing PTx patients with patients who underwent orthopedic surgery (29). Concerning asymptomatic pHPT patients, some randomized control studies found moderate positive effects of operation vs medical care on quality of life (30, 31) while others did not (32).…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Perioperative changes in cortical excitability, mood, and quality of life in patients with primary hyperparathyroidism: a pilot study using transcranial magnetic stimulation

Hermsen

Eienbröker

Haag

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Serum calcium (Ca 2C ) and parathyroid hormone (PTH), amongst others, modify cortical excitability. Alterations in cortical excitability were shown in patients with epilepsy as well as hyper-or hypoparathyroidism. In patients with primary hyperparathyroidism (pHPT), preoperative elevated serum calcium and parathyroidectomy (PTx) may affect mood and quality of life. We hypothesized that perioperative changes in Ca 2C and PTH in pHPT will affect cortical excitability and improve subjective health. Design and methods: Transcranial magnetic stimulation (TMS) was performed before and after surgery in 15 pHPT patients. We measured resting motor threshold, cortical silent period (CSP), short intracortical inhibition, and intracortical facilitation. Health questionnaires were administered before, 1 day and 6 months after PTx, along with the disease-specific Pasieka's parathyroid assessment of symptoms (PAS), which was, to our knowledge, its first use in German.Results: Surgery was successful in all patients. TMS-measurements remained unchanged when analyzing all patients in this pilot study. Postoperatively, depression declined (PZ0.05) and quality of life improved significantly (PZ0.001) in the SF-36-subscales: vitality, social functioning, mental health and subjective health transition (post-hoc analysis). The PAS proved early relief of disease-specific symptoms (P!0.001). Conclusions: We found unchanged cortical excitability comparing pre-and post-PTx in this pilot study. Mood and quality of life improved postoperatively. The German PAS is valuable in detecting disease-specific changes early after PTx.

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 93%

Perioperative changes in cortical excitability, mood, and quality of life in patients with primary hyperparathyroidism: a pilot study using transcranial magnetic stimulation

Hermsen

Eienbröker

Haag

et al. 2014

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Wilheim et al 2004 observed that both depression and quality of life improved in a similar proportion of patients. However, Chiang (Chiang et al .,2005), did not find significant differences in neuropsychological performance between patients undergoing parathyroidectomy and the controls. On the basis of significant improvement in depressive symptoms and quality of life in patients with mild hypercalcemia, parathyroidectomy has been suggested in the management of asymptomatic hyperparathyroidism (Wilheim et al, 2004).…”

Section: Hyperparathyroidismmentioning

confidence: 92%

Thyroid and Parathyroid Diseases and Psychiatric Disturbance

Lobo-Escolar¹,

Campayo²,

Gómez-Biel³

et al. 2012

Thyroid and Parathyroid Diseases - New Insights Into Some Old and Some New Issues

View full text Add to dashboard Cite

“…los estudios sobre los efectos de la paratiroidectomía en la función cognitiva son controvertidos. Algunos estudios muestran mejoría de estos síntomas y mejor calidad de vida [15][16][17] .…”

Section: Figura 1 Test Del Reloj Previo a Cirugía (Izquierda) Y 2 Meunclassified

Deterioro cognitivo e hiperparatiroidismo primario: resultado favorable después de cirugía: Caso clínico

Gac

Carrasco

et al. 2011

Rev. méd. Chile

View full text Add to dashboard Cite

Cognitive impairment associated to primary hyperparathyroidism. report of one case e l envejecimiento de la población es un éxito de la salud pública pero trae nuevos desafíos médicos y sociales 1,2 . la Geriatría ha recalcado la importancia de mantener la funcionalidad (física y mental) a toda edad, por lo que en clínica siempre debemos buscar causas corregibles para tratarlas a tiempo y no denegar tratamientos sólo por la edad del paciente 3,4 . el deterioro cognitivo es una de las entidades que aumentan con la edad por lo que siempre se debe evaluar, ya que hay varias causas descritas como corregibles 5 y una es el hiperparatiroidismo primario que, aunque infrecuente, debemos tenerlo presente si encontramos hipercalcemia en el paciente mayor 6-9 .Presentamos el caso de un sujeto de 79 años, con hiperparatiroidismo primario comprobado, que se presentó a la consulta de Geriatría para estudio de deterioro cognitivo. Caso clínicoPaciente hombre de 79 años, casado, microempresario, con nivel educacional universitario, en tratamiento con escitalopram 10 mg al día por un síndrome depresivo. Consultó por cuadro de cinco meses de evolución caracterizado por ansiedad, dolores musculares generales que eran mayores en la región del cuello, siendo lo principal una pérdida progresiva de su memoria, lo cual fue confirmado también por sus familiares directos. el examen físico fue normal. Se le solicitó TAC cerebral que mostró signos de pérdida de volumen encefálico, descritos como acordes a la edad. el estudio de laboratorio que incluyó hemograma, VhS, función renal, hepática y hormonas tiroideas fue normal, salvo hipercalcemia (10,7 mg/dl), con fósforo de 2,5 mg/dl, albúmina de 4,3 g/dl. esto motivó la solicitud de PTh, la que resultó ser de 106,5 pg/ ml (referencia hasta 65 pg/ml). la vitamina d3 en plasma era 22,5 ng/ml. fue hospitalizado para estudio, solicitándose cintigrama paratiroideo con mibi planar y SPeCT que demostró una glándula paratiroides inferior izquierda hiperfuncionante. la densitometría ósea reveló osteoporosis a nivel de columna lumbar (T-score de -3,3), cadera derecha (T-score de -3,5) y cadera izquierda (T-score de -3,3). la calciuria en orina de 24 horas fue de 390 mg/24 horas. Cintigrama óseo mostró leve

show abstract

A controlled, prospective study of neuropsychological outcomes post parathyroidectomy in primary hyperparathyroid patients

Cited by 57 publications

References 21 publications

Perioperative changes in cortical excitability, mood, and quality of life in patients with primary hyperparathyroidism: a pilot study using transcranial magnetic stimulation

Perioperative changes in cortical excitability, mood, and quality of life in patients with primary hyperparathyroidism: a pilot study using transcranial magnetic stimulation

Thyroid and Parathyroid Diseases and Psychiatric Disturbance

Deterioro cognitivo e hiperparatiroidismo primario: resultado favorable después de cirugía: Caso clínico

Contact Info

Product

Resources

About