A convenient synthesis, biological activity and X-ray crystallography of novel α-aminophosphonate derivatives

Synthesis of Amidophosphates Based on 1-Ethynyl-1-Aminocyclohexane Upon Microwave Activation and their Biological Activity

“…Alicyclic amines are widely used in the synthesis of various functional organophosphorus derivatives of aminocyclocarboxylic acids [6][7][8][9][10][11]. The cyclohexylamine derivatives are of interest as promising neurotropic compounds and anti-inflammatory preparations [12,13].…”

“…In this regard, it is important to develop useful synthesis methods and to study the properties of new phosphorylated acetylenic amines. The presence of several reactive centers in such compounds predetermines great synthetic possibilities and in-Eurasian Chemico-Technological Journal 25 (2023) 57-64 teresting biological properties [8][9][10][11]. Thus, the research for developing the methods for synthesizing new functionally substituted derivatives of alicyclic dialkylamidophosphates, establishing their structure, and searching for promising biologically active compounds in their series, are modern and relevant.…”

Efficient synthesis, crystallography study, antibacterial/antifungal activities, DFT/ADMET studies and molecular docking of novel α-aminophosphonates

“…The target compounds were obtained by a simple and efficient multicomponent Kabachnik-Field reaction from 4-methylaminophenol, various aldehydes and triethylphosphite. The structures of the newly synthesized compounds were determined based on usual spectroscopic data (IR, 1 HNMR , 13 CNMR ). In addition, an X-ray diffraction analysis was performed on the single crystals of compound 3e further confirms the structure of the target molecules.…”

“…In this context, and in connection with our green chemistry program, we recently reported an efficient and "one-pot" three-component procedure for the synthesis of new biologically actives α-aminophosphonates [13]. In this paper, the reactions were carried out by mixing the reagents (aldehyde, hydroxyaniline and triethyl phosphite) over a period of 2-5 min, using microwave-irradiation, in the presence of ZnO nanoparticles as catalyst.…”

Green and Cost-Effective Synthesis of Sulfamidophosphonates Using ZnO Nanoparticles as Catalyst

“…Multicomponent reactions (MCRs) have arisen as a compelling technique in this regard, enabling the facile synthesis of elaborate molecules through a one-pot approach, devoid of the need for intermediate isolation and purification. This affords a reduction in expenses, as well as time and energy consumption, making it a fascinating tool for organic synthesis [4][5][6].…”