2002
DOI: 10.1002/jhet.5570390607
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A convenient synthesis of 2‐Arylidene‐5H‐thiazolo[2,3‐b]quinazo‐line‐3,5[2H]‐diones and their benzoquinazoline derivatives

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Cited by 58 publications
(12 citation statements)
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“…The identities of the products were concluded based on some spectroscopic data, although infrared carbonyl stretching data were inconclusive, there was a distinct pattern in the chemical shifts associated with the carbonyl resonance in the 13 C data. For example the two substituted products 5a and b showed carbonyl carbons resonances around 166-167 ppm, These values were consistent with some appropriate data shown by similar compounds obtained by other researchers in literature [10][11][12][18][19][20][21][22][23][24][25]; hence, based on these, one can conclude that structure 5 is the correct structure for the reaction product rather than its isomer 6. It is so clear to say that in structure 5 the carbonyl group is adjacent to sp 3hybrisized nitrogen atom while in the isomer 6 it is adjacent to more electronegative sp 2 -hybridized nitrogen atom in which the carbonyl carbon chemical shift should show more downfield values than those reported in literature.…”
Section: Resultssupporting
confidence: 90%
“…The identities of the products were concluded based on some spectroscopic data, although infrared carbonyl stretching data were inconclusive, there was a distinct pattern in the chemical shifts associated with the carbonyl resonance in the 13 C data. For example the two substituted products 5a and b showed carbonyl carbons resonances around 166-167 ppm, These values were consistent with some appropriate data shown by similar compounds obtained by other researchers in literature [10][11][12][18][19][20][21][22][23][24][25]; hence, based on these, one can conclude that structure 5 is the correct structure for the reaction product rather than its isomer 6. It is so clear to say that in structure 5 the carbonyl group is adjacent to sp 3hybrisized nitrogen atom while in the isomer 6 it is adjacent to more electronegative sp 2 -hybridized nitrogen atom in which the carbonyl carbon chemical shift should show more downfield values than those reported in literature.…”
Section: Resultssupporting
confidence: 90%
“…Previously it has been reported that although arylalkylidenerhodanines may exist in both Z and E isomeric forms, the thermodynamically more stable Z isomer is the preferred [8–11]. In such reports, configuration on the exocyclic double bond was determined on the basis of NMR spectra.…”
Section: Resultsmentioning
confidence: 99%
“…Rapid Overlay Chemical Similarity (ROCS) study was operated to explain the similarity of the compounds and to figure out the most important pharmacophoric features. Glycosides of structurally similar heterocyclic systems have been reported before [7][8][9][10][11][12][13][14][15].…”
Section: Introductionmentioning
confidence: 99%