A Convenient Synthesis of Highly Substituted 3-N,N-Dialkylamino-1,2,4-triazoles

Abstract

The title compounds are prepared from S-methylisothioureas and acyl hydrazides in moderate to good yields. The reaction is characterized by relatively mild conditions and very broad functional group tolerance.

Synthesis and Characterization of the Triazole Derived from Thiosemicarbazide, 4-Amino-5-Phenyl-4H-1,2,4- Triazole-3-Thiol and Their Copper(II) and Nickel(II) Complexes

“…riazole derivatives have been reported to have pharmacological, insecticidal, fungicidal, and herbicidal activities. [1], the synthesis of these heterocycles has received considerable attention in recent years [2]. The synthesis and metal complex structures of substituted 1,2,4-triazole ligands have gained considerable attention in recent years [3][4][5][6][7] derivatives are very interesting ligands because they combine the coordination geometry of both pyrazole and imidazole with regard to the arrangement of their three heteroatoms.…”

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2,hydrazinecarbothioamide prepared in good yield via the condensation of 4-amino-5-phenyl-4H-1,2,4-triazole-3thiol and thiosemicarbazide. The copper (II) and nickel (II) complexes of the triazole ligand were also prepared.

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