Inverse synthetic-aperture radar (ISAR) can achieve precise imaging of targets, which enables precise perception of battlefield information, and it has become one of the most important tasks for radar systems. In multi-target scenarios, a resource scheduling method is required to improve the sensing ability and the overall efficiency of a radar system due to the limited resources. Considering the motion state of the target will change as the observation distance increases and image defocusing can occur due to the prolonged coherence accumulation time and significant changes in the target’s motion state, the optimal observation period should be an important consideration factor in the resource scheduling method to further improve the imaging efficiency of radar system, which has not yet been involved in existing research. In this paper, we first derive the expressions of the target’s effective rotation angle and the equivalent rotation angular velocity and then define the target’s optimal observation period. Then, for multi-target imaging scenarios, we allocate pulse resources within a given time period based on sparse-aperture ISAR imaging technology. An adaptive radar resource scheduling algorithm for multi-target ISAR imaging is proposed, which prioritizes allocating resources based on the optimal observation periods for the targets. In the algorithm, a radar resource scheduling model for multi-target ISAR imaging is established, and a feedback-based closed-loop search optimization method is proposed to solve the model. Finally, the best scheduling strategy can be obtained, which includes imaging task duration and the pulse allocation sequence for each target. Simulation results validate the effectiveness of the algorithm.