A core–shell liquid metal-Cu nanoparticle with glutathione consumption<i>via</i>an<i>in situ</i>replacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

Yu, Yongnian; Wu, Qiong; Niu, Meng; Gou, Li; Tan, Longfei; Fu, Changhui; Ren, Xiangling; Ren, Jun; Zheng, Yongfa; Meng, Xianwei

doi:10.1039/d2bm00435f

Cited by 18 publications

(12 citation statements)

References 42 publications

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Section: Discussionmentioning

confidence: 99%

“…Yu et al utilized liquid metal eutectic gallium indium to generate ROS under microwave irradiation to achieve a combination therapy with CDT (Figure 6e,f). [144] Wu et al synthesized eutectic gallium indium alloy to generate •OH and •O 2 − under microwave irradiation to achieve a combination of dynamic and thermal therapy (Figure 6g). [145] The generation mechanism of 6h-j).…”

Section: Driven By Microwavementioning

confidence: 99%

“…Schematic diagram of the (e) synthesis steps and (f) therapeutic mechanism of LM@ZrO 2 ‐Cu@ionic liquid (LM@ZrO 2 ‐Cu@IL). Reproduced with permission [144] . Copyright 2022, Royal Society of Chemistry.…”

Section: The Nanocatalytic Therapy Driven By Magnetic Fieldmentioning

confidence: 99%

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External physical field‐driven nanocatalytic cancer therapy

Zhang

Liu

2023

BMEMat

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Recently, variable nanocatalysts have provided novel, highly selective, minimally invasive strategies driven by external physical fields for cancer therapy. In the catalytic reaction, less toxic or nontoxic substances can be in situ converted into toxic agents for cancer suppression. In this review, we systematically summarize the catalytic cancer therapy based on different types of external physical fields, including light, ultrasound, electricity, temperature, X-ray, magnetic field, and microwave. The properties, mechanisms, and advantages of the corresponding external physical fields in cancer therapy are also introduced. Importantly, considering the rapid development of catalytic nanomedicine, the research progress of catalytic cancer therapy driven by external physical fields is discussed. Finally, the remaining challenges and outlooks that catalytic cancer therapy faced are also outlined. We believe that the emerging external physical fields-driven nanocatalytic cancer therapy will provide a new avenue for cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Driven By Microwavementioning

confidence: 99%

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External physical field‐driven nanocatalytic cancer therapy

Zhang

Liu

2023

BMEMat

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“…[ 83–85 ] In many cases, such shells exhibit enhancements in liquid metal functionality. [ 84,86,87 ] For example, Guo et al. [ 88 ] found that in situ reduced gold‐coated liquid metal nanodroplets exhibited stronger photothermal conversion effects.…”

Section: Liquid Metal Compositesmentioning

confidence: 99%

“…[83][84][85] In many cases, such shells exhibit enhancements in liquid metal functionality. [84,86,87] For example, Guo et al [88] found that in situ reduced gold-coated liquid metal nanodroplets exhibited stronger photothermal conversion effects. Liquid gallium@reduced graphene oxide core-shell nanoparticles synthesized by Zhang et al [89] demonstrated improved photothermal and photoacoustic properties.…”

Section: Liquid Metal Core-shell Compositesmentioning

confidence: 99%

Toxicity and Biocompatibility of Liquid Metals

Chen

Zhao

Sun

et al. 2022

Adv Healthcare Materials

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Recently, room-temperature liquid metals have attracted increasing attention from researchers owing to their excellent material properties. Systematic interpretation of the potential toxicity issues involved is essential for a wide range of applications, especially in the biomedical and healthcare fields. However, even with the exponential growth of related studies, investigation of the toxicological impact and possible hazards of liquid metals to organisms is still in its infancy. This review aims to provide a comprehensive summary of the current frontier of knowledge on liquid metal toxicology and biocompatibility in different environments. Based on recent studies, this review focuses on Ga and Bi-based in different states. It is necessary to evaluate their toxicity considering the rapid increase in research and utilization of such liquid metal composites. Finally, existing challenges are discussed and suggestions are provided for further investigation of liquid metal toxicology to clarify the toxicological mechanisms and strategies are provided to avoid adverse effects. In addition to resolving the doubts of public concern about the toxicity of liquid metals, this review is expected to promote the healthy and sustainable development of liquid metal-based materials and their use in diverse areas, especially those related to health care.

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AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non‐Thermal Microwave Cancer Therapy

Lyu

et al. 2023

Adv Healthcare Materials

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Aggregation‐induced emission luminogens (AIEgens) are widely used as photosensitizers for image‐guided photodynamic therapy (PDT). Due to the limited penetration depth of light in biological tissues, the treatments of deep‐seated tumors by visible‐light‐sensitized aggregation‐induced emission (AIE) photosensitizers are severely hampered. Microwave dynamic therapy attracts much attention because microwave irradiation can penetrate very deep tissues and sensitize the photosensitizers to generate reactive oxygen species (ROS). In this work, a mitochondrial‐targeting AIEgen (DCPy) is integrated with living mitochondria to form a bioactive AIE nanohybrid. This nanohybrid can not only generate ROS under microwave irradiation to induce apoptosis of deep‐seated cancer cells but also reprogram the metabolism pathway of cancer cells through retrieving oxidative phosphorylation (OXPHOS) instead of glycolysis to enhance the efficiency of microwave dynamic therapy. This work demonstrates an effective strategy to integrate synthetic AIEgens and natural living organelles, which would inspire more researchers to develop advanced bioactive nanohybrids for cancer synergistic therapy.

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A core–shell liquid metal-Cu nanoparticle with glutathione consumptionviaanin situreplacement strategy for tumor combination treatment of chemodynamic, microwave dynamic and microwave thermal therapy

Abstract: A stable core–shell spherical “storage pool” was obtained, which could realize the combination of chemodynamic, microwave dynamic and microwave thermal therapy.

Cited by 18 publications

References 42 publications

External physical field‐driven nanocatalytic cancer therapy

External physical field‐driven nanocatalytic cancer therapy

Toxicity and Biocompatibility of Liquid Metals

AIEgens/Mitochondria Nanohybrids as Bioactive Microwave Sensitizers for Non‐Thermal Microwave Cancer Therapy

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