A core–shell metal–organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells

Abstract

In this work, core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells.

Metal–Organic Framework‐Based Stimuli‐Responsive Systems for Drug Delivery

“…The core–shell nanocomposite UCNPs/MB@ZIF‐8@catalase (UCNPs, upconversion NPs; MB, methylene blue) was developed for NIR/H 2 O 2 ‐responsive photodynamic therapy against hypoxic tumor cells . The synthesis procedure involved a one‐pot assembly of a UCNPs/MB@ZIF‐8 core–shell structure and the subsequent surface functionalization of the shell with catalase.…”

Recent advances in metallopolymer-based drug delivery systems

“…However, using multiple stimuli-responsive polymers is more effective to achieve more precise cancer therapies. Among the most interesting examples, we note pH/ GSH-, 259,260 NIR/H 2 O 2 -, 261 and ATP/Mg 2+ ion-responsive systems. 262…”

Therapeutic Nanoreactors as In Vivo Nanoplatforms for Cancer Therapy

“…Owing to both extraordinary organic and inorganic characteristics which endorse their high loading capacity, MOF nanoparticles (nMOFs) have been applied in various utilities ranging from gas storage/separation and catalysis to nanomedicine applications including biomedical imaging and drug delivery . Moreover, according to the versatile topological structure of nMOFs with potential void matrices that can be used to immobilize various biological active macromolecules as wells as porous surfaces, which can allow the transport of substrates and products across the porous gates, these hybrid nanoassemblies have been recently emerged as the novel reaction vessels to engineer therapeutic nanoreactors …”