Background:The pathophysiological importance of autophagy in renal tubules during the development of diabetic nephropathy (DN) has been implicated. Results: Autophagy was inactivated because lysosomal membrane permeabilization and lysosomal dysfunction were triggered by advanced glycation end products. Conclusion:The autophagy-lysosome pathway is disrupted in renal tubules in DN. Significance:The findings open a new field for studying the mechanisms of DN.

In this work, core–shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells.

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