Coriolis mass flowmeters are highly customized products involving high-degree fluid-structure coupling dynamics and high-precision manufacture. The typical delay from from order to shipment is at least 4 months. This paper presents some important design considerations through simulation and experiments, so as to provide manufacturers with a more time-efficient product design and manufacture process. This paper aims at simulating the fluid-structure coupling dynamics of a dual U-tube Coriolis mass flowmeter through the COMSOL simulation package. The simulation results are experimentally validated using a dual U-tube CMF manufactured by Yokogawa Co., Ltd. in a TAF certified flow testing factory provided by FineTek Co., Ltd. Some important design considerations are drawn from simulation and experiment. The zero drift will occur when the dual U-tube structure is unbalanced and therefore the dynamic balance is very important in the manufacturing of dual U-tube CMF. The fluid viscosity can be determined from the driving current of the voice coil actuator or the pressure loss between the inlet and outlet of CMF. Finally, the authors develop a simulation application based on COMSOL’s development platform. Users can quickly evaluate their design through by using this application. The present application can significantly shorten product design and manufacturing time.