HB11 Energy’s mission is to realize large-scale electricity generation from the fusion of hydrogen with boron-11 (the HB11, or “proton-boron”, reaction) without the environmental problems normally associated with nuclear energy. A non-thermal approach is taken in the initiation of the reaction using high-peak-power lasers, which was the pursuit of HB11 Energy founder Prof. Heinrich Hora’s career as a theoretical physicist. In the 1980s, the invention of Chirped Pulse Amplification (CPA) of laser pulses by Donna Strickland and Gerard Mourou (Nobel Prize 2018) enabled the possibility of experimentally validating the earlier theoretical predictions. Several experimental demonstrations of the HB11 reaction using CPA lasers inspired the establishment of HB11 Energy and with it, the possibility of realizing an aneutronic nuclear energy source with easily accessible and safe fuel resources that could last thousands of years. Like all quests for fusion energy, there are significant scientific challenges remaining. HB11 Energy Holdings Pty Ltd, an Australian company, was established as the best vehicle to co-ordinate a global collaborative research effort to address these challenges and build capacity to host large-scale public private partnerships, such as those now recommended by the US National Academies of Science, Engineering and Medicine (NASEM) (US National Academies of Sciences, Engineering and Medicine in Bringing Fusion to the U.S. Grid,: National Academies Press, Washington, D.C, 2021). If net-energy-gain can be achieved through HB11 Energy’s concepts, there are many engineering benefits over traditional DT fusion that will see a dramatically simpler and safer reactor being produced. A technoeconomic assessment of such a reactor is also discussed which presents many engineering challenges that will need to be met before commercial HB11 fusion can be deployed on a large-scale.