A Correlative Study between Platelet Count, Mean Platelet Volume and Red Cell Distribution Width with the Disease Severity Index in Psoriasis Patients

Raghavan, Vasudevan; Rkn, Radha; Rk, Rao; Kuberan, A

doi:10.7860/jcdr/2017/31172.10639

Cited by 19 publications

(26 citation statements)

References 20 publications

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“…Pro-inflammatory cytokines, microvascular disorder, and dysregulated erythropoiesis contribute to increased cardiovascular risk. In accordance with recent publications, RDW is a reliable, strong prognostic marker of cardiovascular disease, and MPV contributes to a more detailed assessment of cardiovascular risk in patients that have a lower level of inflammation [16,47].…”

Section: Discussionsupporting

confidence: 85%

“…Recently, these markers have been associated with increased MACE in large undifferentiated patient populations and in HIV patient cohorts [8,[11][12][13]. Limited evidence for elevated levels of MPV and RDW in a greater percentage of psoriasis patients has been identified previously in small sample size cohorts; however, the risk of MACE and CVD in psoriasis patients with aberrant RDW and MPV values remains to be determined [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

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Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Conic

Damiani

Schrom

et al. 2020

JCM

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In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) and mean platelet volume (MPV) are readily available clinical tests that reflect responses of the bone marrow and/or plasma thrombogenicity (e.g., inflammation), and can be markers for major adverse cardiac events (MACE). We aimed to evaluate if RDW and MPV may be employed as inexpensive, routinely obtained biomarkers in predicting myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) in psoriatic and psoriatic arthritis patients. The study was divided into two parts: (a) case control study employing big data (Explorys) to assess MPV and RDW in psoriasis, psoriatic arthritis and control cohorts; (b) a clinical observational study to validate the predictive value of RDW and to evaluate RDW response to anti-psoriatic therapies. We used Explorys, an aggregate electronic database, to identify psoriatic patients with available MPV and RDW data and compared them to gender and age matched controls. The incidence of myocardial infarction (MI), atrial fibrillation (AF), and chronic heart failure (CHF) was highest among patients with both elevated RDW and MPV, followed by patients with high RDW and normal MPV. RDW elevation among PsA patients was associated with an increased risk of MI, AF, and CHF. In a local clinical cohort, high RDWs were concentrated in a subset of patients who also had elevated circulating resistin levels. Among a small subset of participants who were treated with various systemic and biologic therapies, and observed over a year, and in whom RDW was elevated at baseline, a sustained response to therapy was associated with a decrease in RDW. RDW and MPV, tests commonly contained within routine complete blood count (CBC), may be a cost-effective manner to identify PsO and PsA patients at increased risk of MACE.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Conic

Damiani

Schrom

et al. 2020

JCM

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“…It is indicated that it may be increased due to inflammation and may be used as a convenient marker of inflammation (37). MPV is a parameter that has been investigated in the practice of dermatology in psoriasis, urticaria, Behçet's disease, pemphigus vulgaris, and diseases including BP, and it yields conflicting results in some diseases (19,21,(38)(39)(40)(41)(42). Although there are studies showing that MPV is increased in patients with psoriasis (19,38), Işık et al stated in their study that there was no difference in MPV levels between psoriasis patients and the control group (39).…”

Section: Discussionmentioning

confidence: 99%

“…The mean platelet volume (MPV) is a widely used measure of platelet size, and it was also found to be directly related to the metabolic activities of platelets (18). MPV has previously been found to be elevated in many inflammatory skin diseases such as pemphigus vulgaris, urticaria and psoriasis (19,20). It has been reported that MPV may increase due to bone marrow stimulation caused by inflammation and may be used as an inflammatory marker (20).…”

Section: Introductionmentioning

confidence: 99%

Can Neutrophil/Lymphocyte Ratio be Used As a Marker in The Diagnosis of Bullous Pemphigoid

Özer

2018

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Amaç: Büllöz pemfigoid (BP) dermo-epidermal bileşkede yer alan antijenlere karşı oluşan antikorların neden olduğu, sıklıkla ileri yaş döneminde izlenen büllöz bir dermatozdur. Otoantikorların tetiklediği inflamasyon sonucunda hasta serumlarında ve büllerde inflamatuar mediatörlerin artmış olduğu ve artan bu mediatörlerin hastalık şiddeti ile ilişkili olabileceği bildirilmiştir. Nötrofil lenfosit oranı (NLO); nötrofil sayısının lenfosit sayısına bölünmesi ile elde edilen; daha önce ürtiker, psoriazis, pemfigus vulgaris ve kutanöz vaskülit gibi inflamatuar hastalıklarda incelenmiş ve hastalıkla ilişkili bulunmuş bir parametredir. Bu çalışmada; sistemik inflamasyonun bir belirteci olan NLR'nin BP'li hastalarda kullanılabilecek bir belirteç olup olmadığı araştırılmada çalışılmıştır. Hastalar ve Yöntem: Ocak 2013-Aralık 2017 tarihleri arasında BP tanısı konulmuş hastaların medikal kayıtları incelendi. Dosyalarındaki laboratuar sonuçları değerlendirilerek; ortalama trombosit hacmi (MPV), nötrofil sayısı, lenfosit sayısı ve nötrofil sayısının lenfosit sayısına bölünerek hesaplandığı nötrofil lenfosit oranı kayıt edildi. Bulgular: Çalışmaya, 26 BP'li hasta ve 25 kontrol grubu hasta dahil edildi. BP'li hastalarda nötrofil sayısının (P = 0,005) ve NLO'nın (P = 0,04) kontrol grubundan yüksek olduğu görüldü. Lenfosit sayısının BP'li hastalarda kontrol grubundan farklı olmadığı saptandı. Sonuç: Çalışmamız; etyopatogenezinde inflamasyonun yer aldığı BP'li hastalarda bildiğimiz kadarı ile NLO'yi araştıran ilk çalışmadır. Sistemik inflamasyon için tam kan sayımı ile kolayca hesaplanabilecek bir parametre olan NLO'nın BP tanısında kullanılabilecek bir belirteç olabileceğini düşünmekteyiz.

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“…In psoriasis, several studies reported that the plasma PMPs and P-selectin levels were significantly correlated with the psoriasis area and the severity index (PASI) score (203, 218). Recently, Raghavan et al proposed a strong correlation between the PASI score and MPV values and platelet counts (219). However, further research is required to confirm the usability of platelet related parameters for the diagnosis and the monitoring of AAV, CU, and psoriasis.…”

Section: Platelets Role In Skin Autoimmune Diseasesmentioning

confidence: 99%

Platelets in Skin Autoimmune Diseases

2019

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Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis are three autoimmune diseases frequently manifested in the skin. They share common pathogenic features, including production of autoantibodies, loss of tolerance to self-antigens, tissue necrosis and fibrosis, vasculopathy and activation of the coagulation system. Platelets occupy a central part within the coagulation cascade and are well-recognized for their hemostatic role. However, recent cumulative evidence implicates their additional and multifaceted immunoregulatory functions. Platelets express immune receptors and they store growth factors, cytokines, and chemokines in their granules enabling a significant contribution to inflammation. A plethora of activating triggers such as damage associated molecular patterns (DAMPs) released from damaged endothelial cells, immune complexes, or complement effector molecules can mediate platelet activation. Activated platelets further foster an inflammatory environment and the crosstalk with the endothelium and leukocytes by the release of immunoactive molecules and microparticles. Further insight into the pathogenic implications of platelet activation will pave the way for new therapeutic strategies targeting autoimmune diseases. In this review, we discuss the inflammatory functions of platelets and their mechanistic contribution to the pathophysiology of SSc, ANCA associated small vessel vasculitis and other autoimmune diseases affecting the skin.

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A Correlative Study between Platelet Count, Mean Platelet Volume and Red Cell Distribution Width with the Disease Severity Index in Psoriasis Patients

Cited by 19 publications

References 20 publications

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Psoriasis and Psoriatic Arthritis Cardiovascular Disease Endotypes Identified by Red Blood Cell Distribution Width and Mean Platelet Volume

Can Neutrophil/Lymphocyte Ratio be Used As a Marker in The Diagnosis of Bullous Pemphigoid

Platelets in Skin Autoimmune Diseases

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