2021
DOI: 10.1016/j.cirpj.2021.01.015
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A cost-effective process chain for thermoplastic microneedle manufacture combining laser micro-machining and micro-injection moulding

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Cited by 41 publications
(30 citation statements)
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“…The latest additive manufacturing and 3D printing processes manufacturing is a great breakthrough for plastic gears manufacturing, but it is mainly used in small batch production [ 8 ]. At present, plastic gears are mainly manufactured by injection molding [ 9 , 10 , 11 ] because of its low production cost and short production cycle. The injection molding technology for conventional gears is mature and can basically meet the use requirements.…”
Section: Introductionmentioning
confidence: 99%
“…The latest additive manufacturing and 3D printing processes manufacturing is a great breakthrough for plastic gears manufacturing, but it is mainly used in small batch production [ 8 ]. At present, plastic gears are mainly manufactured by injection molding [ 9 , 10 , 11 ] because of its low production cost and short production cycle. The injection molding technology for conventional gears is mature and can basically meet the use requirements.…”
Section: Introductionmentioning
confidence: 99%
“…[178] Thus, the pressure exerted by individual needle tips may be insufficient to penetrate the skin so that a higher applied force is required. [179] Moreover, the inter-needle skin topology prior to puncture results in pressure reductions at the tips which also reduces their effectiveness in puncturing the skin with consequently reduced APE. [28] It is noteworthy that the number of MNs also affected the pain score, where a tenfold increase in MN projections increased the pain score just over twofold, [41] and also may result in reduction in drug permeability due to bed of nails effects.…”
Section: Geometrical Effectsmentioning
confidence: 99%
“…The product used in the present study is based on a 0.5-mmthick circular disc shape with 17 mm diameter which accommodates an array of microneedle cavities in 6×6 configuration in a μIM tool as discussed in our previous study [2,22]. The quality proxy of the moulded products in this work has been defined as the microreplication efficiency of the microneedle features (M μ ) obtained from each part or manufacturing cycle.…”
Section: Part Design and Process Detailsmentioning
confidence: 99%
“…Pressure sustained during at any stage of μIM is of importance and can be a reliable process quality indicator [8,22,24]. Viscosity of a polymer can be considered as resistance to flow, and higher viscosities result in bigger pressure drops in polymer processing.…”
Section: Derived Process Fingerprints (Dpfs)mentioning
confidence: 99%