“…The first tumor of which the molecular nature of cancer was discovered was retinoblastoma. (1), (2), (3), (4), (5), ( 6), (7), Even though genetic mutations affect all retinoblastoma tumors, this does not indicate that all patients have contracted the disorder or that all specimens are passable to the next generation. Recent research has shown that retinoblastoma tumors may vary in their mutagenic pathways from regular to malignant cells; for example, some retinoblastoma tumors are induced by RB1 mutations [1,2,3,4,5], whereas others are caused by MYCN gene amplification.…”