A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Hammond, Andrew; Galizi, Roberto; Kyrou, Kyros; Simoni, Alekos; Siniscalchi, Carla; Katsanos, Dimitris; Gribble, Matthew O.; Baker, Dean A.; Marois, Eric; Russell, Steven; Burt, Austin; Windbichler, Nikolai; Crisanti, Andrea; Nolan, Tony

doi:10.1038/nbt.3439

Cited by 1,086 publications

(1,274 citation statements)

References 33 publications

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“…This holds great promise, as the release of organisms containing a gene drive could-in just several generations-result in the replacement of a given gene with a version designed by humans. Perhaps the simplest and most compelling example of this is a proposal to eliminate malaria by releasing mosquitoes that carry a gene-drive version of a gene that compromises the mosquito's ability to serve as a vector of the Plasmodium parasite (Hammond et al 2016). Similar ideas could be used to suppress weed populations, for example, by rendering herbicide-resistant populations of Palmer amaranth (Amaranthus palmeri S.…”

Section: Rna Interference Herbicides and Genetic Engineeringmentioning

confidence: 99%

Weed Management in 2050: Perspectives on the Future of Weed Science

et al. 2018

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The discipline of weed science is at a critical juncture. Decades of efficient chemical weed control have led to a rise in the number of herbicide-resistant weed populations, with few new herbicides with unique modes of action to counter this trend and often no economical alternatives to herbicides in large-acreage crops. At the same time, the world population is swelling, necessitating increased food production to feed an anticipated 9 billion people by the year 2050. Here, we consider these challenges along with emerging trends in technology and innovation that offer hope of providing sustainable weed management into the future. The emergence of natural product leads in discovery of new herbicides and biopesticides suggests that new modes of action can be discovered, while genetic engineering provides additional options for manipulating herbicide selectivity and creating entirely novel approaches to weed management. Advances in understanding plant pathogen interactions will contribute to developing new biological control agents, and insights into plant-plant interactions suggest that crops can be improved by manipulating their response to competition. Revolutions in computing power and automation have led to a nascent industry built on using machine vision and global positioning system information to distinguish weeds from crops and deliver precision weed control. These technologies open multiple possibilities for efficient weed management, whether through chemical or mechanical mechanisms. Information is also needed by growers to make good decisions, and will be delivered with unprecedented efficiency and specificity, potentially revolutionizing aspects of extension work. We consider that meeting the weed management needs of agriculture by 2050 and beyond is a challenge that requires commitment by funding agencies, researchers, and students to translate new technologies into durable weed management solutions. Integrating old and new weed management technologies into more diverse weed management systems based on a better understanding of weed biology and ecology can provide integrated weed management and resistance management strategies that will be more sustainable than the technologies that are now failing.

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Section: Rna Interference Herbicides and Genetic Engineeringmentioning

confidence: 99%

Weed Management in 2050: Perspectives on the Future of Weed Science

et al. 2018

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“…These recommendations are already being adopted by most gene drive researchers (e.g. Hammond et al 2016).…”

Section: Anomaly Resolution Through Anomaly Modificationmentioning

confidence: 99%

Anomaly handling and the politics of gene drives

Evans

Palmer

2017

Journal of Responsible Innovation

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Decisions about the development and use of gene drives are framing broader debates about the need for fundamental changes to biotechnology regulatory systems. We summarize this debate and describe how gene drives are being constructed as potential anomalies within the regulatory landscape. Drawing on literature from Science and Technology Studies and other fields, we outline a broad set of anomaly-handling strategies and provide examples from current gene drive debates. While often couched in technical terms, decisions about how to address anomalies are also decisions about whether to strengthen or weaken different forms of governance. By exploring the different ways that anomalies are constructed and handled, we highlight the active role that anomalies play within a changing governance system and invite a more nuanced examination of the multifarious goals these strategies serve.ARTICLE HISTORY

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“…The inserted DNA encoded engineered antibodies that attack the malaria parasites. In the laboratory, this feature was extended to 99.5 percent of the offspring from matings between modified and unmodified mosquitoes [37][38][39].…”

Section: Crispr In the Treatment Of Hiv Infectionmentioning

confidence: 99%

CRISPR genome editing and its medical applications

Mahmoudian-Sani

Farnoosh

Mahdavinezhad

et al. 2017

Biotechnology & Biotechnological Equipment

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Genome editing has always been a challenging area as a means to provide more efficient ways to create a meaningful change in the genome. Today, the CRISPR (clustered regularly interspaced short palindromic repeat) restoration system is considered as one of the suitable and promising options for genome editing. This system has many advantages compared to the previous geneediting methods developed in this area. Compared to the previous systems, CRISPR can deactivate or eliminate a gene without interfering with intracellular mechanisms. The system can be used in the treatment of diseases and in related research with identifying the performance of defective genes in these diseases. CRISPR has more potentials and applications compared to previous systems. Among these applications, we can note the use of CRISPR in understanding genetic and epigenetic diseases such as cancer. Study of cancer by the CRISPR system is done by two approaches: turning off the oncogenes and turning on the tumour suppressor genes. According to the exact capability of CRISPR, this system can also be used to create exact mutations in different cell lines to model the cancers. This type of modeling can lead to a better understanding of cancer and the ability to develop effective drugs.

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A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae

Cited by 1,086 publications

References 33 publications

Weed Management in 2050: Perspectives on the Future of Weed Science

Weed Management in 2050: Perspectives on the Future of Weed Science

Anomaly handling and the politics of gene drives

CRISPR genome editing and its medical applications

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