A Critical Analysis of Strontium Bone Scanning for Detection of Metastatic Cancer

Nd, Charkes; Dm, Sklaroff; Young, Irving

doi:10.2214/ajr.96.3.647

Cited by 65 publications

(12 citation statements)

References 13 publications

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“…being absorbed into bone with a direct relationship between bone formation and isotope uptake (Charkes et al 1966). Hambury et al (1971) also used this property of the isotope for a scanning procedure to calculate bone formation but found no consistent evidence of increased bone formation in rabbit femora after 3 weeks' stimulation with direct current.…”

Section: 'mentioning

confidence: 99%

The Effect of Transistor-Regulated Direct Current on Non-Fractured Rabbit Femur

Petersson

Holmer

Johnell

1982

Acta Orthopaedica Scandinavica

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Section: 'mentioning

confidence: 99%

The Effect of Transistor-Regulated Direct Current on Non-Fractured Rabbit Femur

Petersson

Holmer

Johnell

1982

Acta Orthopaedica Scandinavica

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“…[18] In order to diagnose a metastatic cancer in trabecular bone, 30-50% bone destruction is required. [19] Scintigraphy, despite its limited accuracy is a good screening tool and can be systematically performed. [1,20] Radionuclide bone scanning using technetium-labeled polyphosphonates was shown to detect bone metastasis several months earlier than plain radiographs.…”

Section: Discussionmentioning

confidence: 99%

Solitary spinous process metastasis: a case report

Demirçay

Çivelek

Demıralay

2013

Eklem Hastalik Cerrahisi

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Primary malignant tumors frequently metastasize to bone, third in frequency after liver and lung. [1] Breast, lung, prostate, and kidney cancers have been the most common malignancies with secondary spine involvement.[2] Breast and prostate cancers have particular clinical interest because of the prevalence of these diseases, with about 70% of the patients dying of these cancers having evidence of metastatic bone disease.[3] Bone metastases are also seen in carcinomas of the thyroid, kidney, and bronchus with an incidence of 30-40% at postmortem examination.[3] However, tumors of the gastrointestinal tract rarely (<10%) metastasize to the bone. [3] Sistemik malignitesi olan kemik metastazları vertebral kolonda sık görülür. Metastatik spinal tümörlü hastalar genellikle ağrı ile başvurur. Bazı tümörler asemptomatiktir ve tarama muayeneleri sırasında tespit edilebilir. Spinal metastaz tanısında vertebral kolona yönelik manyetik rezonans görüntüleme (MRG) ile birlikte mevcut olan diğer görüntüleme yöntemleri ve klinik muayene bulguları kullanılmalıdır. Kırk beş yaşında bir erkek bel ağrısıyla başvurdu. Rektum cerrahisi ve radyoterapi öyküsü olan hasta rektum adenokarsinomu için kemoterapi almaktaydı. Üç hafta önce yapılan F18 sodyum florid pozitron emisyon tomografisi taramasında primer cerrahi alan dışında bir anormallik yoktu. Lomber vertebra MRG'sinde L4 spinöz çıkıntı ucunda bir lezyon bulundu. L4 spinöz çıkıntıya eksizyonel biyopsi yapıl-dı. Histolojik inceleme sonucu musinöz adenokarsinom saptandı. İki aylık takipte hastanın bel ağrısı olmadı. İngilizce literatürde daha önce bildirilmiş soliter spinöz çıkıntı metastazına rastlamadık. Geçmişinde kanser öyküsü olan ve nonspesifik spinal ağrısı olan hastalarda spinal metastaz olasılığı dikkatle araştırılmalıdır. Soliter bir spinöz çıkıntı lezyonu dahi spinal metastazın ilk belirtisi olabilir.Anahtar sözcükler: Kemik dokusu; bel ağrısı; neoplazm metastazı; neoplazmlar; omurga.Vertebral column is a common site for bony metastases in patients with systemic malignancy. Patients with metastatic spinal tumors usually present with pain. Some tumors are asymptomatic and can be detected during screening examinations. Magnetic resonance imaging (MRI) of the vertebral column with the panel of available imagining methods and the clinical findings should be used for the diagnosis of spinal metastasis. A 45-year-old man was admitted with low back pain. With a history of rectum surgery and radiotherapy, he was on chemotherapy for rectum adenocarcinoma. F18 sodium fluoride positron emission tomography scan which was performed three weeks ago showed no abnormalities other than the primary surgical site. Magnetic resonance imaging of the lumbar vertebrae spine revealed a lesion on the tip of L4 spinous process. Excisional biopsy of L4 spinous process was performed. Histologic examination revealed mucinous adenocarcinoma. He had no low back pain at two-months follow-up. We could not find any solitary spinous process metastasis reported in English literature. Patients with nonspecif...

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“…Bone scanning for metastatic tumour As outlined the major application of bone scanning is in the detection of occult bony metastases. The mechanism behind the local increase in bone seeking agents in the region of bone tumours has been investigated by Charkes, Sklaroff & Young (1966) who found a close relationship between the presence of immature reactive bone formed in response to tumour cells and localized increased concentration of 85strontium. The appearance of an abnormal bone scan may precede radiological abnormalities.…”

Section: Radiopharmaceuticalsmentioning

confidence: 99%

Radioisotope scanning of brain, liver, lung and bone with a note on tumour localizing agents

Lavender

1973

Postgraduate Medical Journal

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SummaryRadioisotopic scanning of brain, liver, lungs and the skeleton is briefly reviewed with a survey of recent developments of clinical significance. In brain scanning neoplasm detection rates of greater than 90%O are claimed. The true figure is probably 70-80%. Autopsy data shows a number of false negatives, particularly with vascular lesions. Attempts to make scanning more specific in differentiating neoplasm from vascular lesions by rapid sequence blood flow studies are reviewed.In liver scanning by means of colloids again high success rate is claimed but small metastases are frequently missed and the false negative scan rate is probably quite high.Lung scanning still has its main place in investigating pulmonary embolic disease. Ventilation studies using Xenon 133 are useful, particularly combined with perfusion studies.The various radiopharmaceuticals for use in bone scanning are reviewed. The appearance of technetium labelled phosphate compounds will probably allow much wider use of total skeletal scanning.Research into tumour localizing agents continues, the most recent and interesting being Gallium citrate and labelled bleomycin. Neither agent is predictable however although Gallium may have a place in Hodgkins disease and bronchogenic neoplasm and both may have a place in the detection of cerebral tumours. IntroductionThis brief review is intended to look at some of the more common applications of radioisotope scanning, and also at certain new developments, in their clinical setting. Recent changes in detecting apparatus and in radiopharmaceuticals are widening the scope of scanning procedures, making investigations more specific; this outline may indicate the type of information and the order of accuracy that can be expected from the various investigations covered.

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A Critical Analysis of Strontium Bone Scanning for Detection of Metastatic Cancer

Cited by 65 publications

References 13 publications

The Effect of Transistor-Regulated Direct Current on Non-Fractured Rabbit Femur

The Effect of Transistor-Regulated Direct Current on Non-Fractured Rabbit Femur

Solitary spinous process metastasis: a case report

Radioisotope scanning of brain, liver, lung and bone with a note on tumour localizing agents

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