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Fat tolerance tests with radioactive triolein were performed on a group of patients with coronary atherosclerosis or hypercholesterolemia, and significant differences from normal subjects were observed. The mechanisms and implications of these abnormalities are discussed. In 1949 Thannhauser and Stanley reported a method for the study of the metabolism of neutral fat in human subjects utilizing 1131-labeled olive oil.l6 It had several distinct advantages: (1) the required amount of labeled fat was small and well tolerated, (2) the radioactive iodine was easily measured in the serum, (3) the proportion of the radioactive iodine that split off the fatty acid molecule could be determined and information ATHEROSCLEROSIS and its accompanyFrom the