Studies of Metastatic Bone Lesions with Strontium 85

Dm, Sklaroff; Nd, Charkes

doi:10.1148/80.2.270

Cited by 28 publications

(6 citation statements)

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“…The principle is that Tc‐99m‐MDP accumulates in areas of active bone turnover, depending on the degree of osteoblastic and metabolic activity and vascularization (Schwartz et al 1993; McCracken et al 2001). Unlike insensitive X‐ray radiography, bone scintigraphy can demonstrate slight changes in bone (Sklaroff & Charkes 1963; Mari et al 1999). Bone scintigraphy has a high sensitivity (Sklaroff & Charkes 1963; Thomann & Dul 1994; Mari et al 1999) with a low specificity.…”

Section: Discussionmentioning

confidence: 99%

“…Unlike insensitive X‐ray radiography, bone scintigraphy can demonstrate slight changes in bone (Sklaroff & Charkes 1963; Mari et al 1999). Bone scintigraphy has a high sensitivity (Sklaroff & Charkes 1963; Thomann & Dul 1994; Mari et al 1999) with a low specificity. While it can show osteogenic activity, it is not possible to understand a pathological condition by using only scintigraphies.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Kalaycı

Durmuş

Taştekin

et al. 2010

Clinical Oral Implants Res

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Objectives: The aim of this study was to evaluate the osteoblastic activity around delay‐loaded intraosseous dental implants using nuclear medicine imaging techniques. Material and methods: Seven totally edentulous patients (two females and five males, between 48 and 57 years of age) were included in the study. Two implants were inserted into mandibular canine regions and removable prostheses were produced after 3 months. Whole‐body bone scintigraphies with 20 mCi technetium 99m labelled methylene diphosphonate were taken from the patients before implant insertion, 3 months after implant placement just before the prostheses were made and 1 year after implant placement. Standardized count/pixel (SC/P) rates were calculated for each patient. Preimplantation SC/P values were compared with the 3‐ and 12‐month values. Three‐month values were compared with the 12‐month values as well. Results: SC/P rates in the third month were significantly higher (P<0.05) than preoperative values and the SC/P rates of the 12th month were significantly lower (P<0.05) than 3‐month values. The SC/P rates of the 12th month were relatively higher than first scintigraphies but the difference was insignificant (P>0.05). Conclusions: Within the limitations of this study, in which delayed loading was applied, we showed that osteoblastic activity persisted more in delay loaded implants than immediate and early loading. After 1 year, there was no cellular activity around two implants and this implied that two implants were sufficient for a total prosthesis. To cite this article:  Kalayci A, Durmus E, Tastekin G, Isik K, Inan Ö. Evaluation of osteoblastic activity around dental implants by using bone scintigraphy. Clin. Oral Impl. Res. 21, 2010; 209–212. doi: 10.1111/j.1600‐0501.2009.01822.x

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Kalaycı

Durmuş

Taştekin

et al. 2010

Clinical Oral Implants Res

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“…For instance, Ba 2+ and Sr 2+ complexes are emerging as effective catalysts for a wide range of reaction types, such as imine (17) and olefin (18)(19)(20) hydrogenation, hydroaminations (21)(22)(23)(24)(25), dehydrocouplings (26)(27)(28), and polymerizations (29)(30)(31), among others (32)(33)(34)(35)(36). Other applications include emerging use of Ra 2+ , Ba 2+ , and Sr 2+ in the medical field as diagnostics and therapeutics: examples are alpha therapy ( 223 Ra and 224 Ra) (4-9), single-photon emission computed tomography ( 131 Ba and 135m Ba) (10), and radiography ( nat Ba, 85 Sr, and 87m Sr) (11)(12)(13). All of the aforementioned heavy alkaline earth chemistry would benefit from advancing chelation strategies and complexation methodology for Ra 2+ , Ba 2+ , and Sr 2+ .…”

Section: Introductionmentioning

confidence: 99%

Advances in heavy alkaline earth chemistry provide insight into complexation of weakly polarizing Ra ²⁺ , Ba ²⁺ , and Sr ²⁺ cations

Gilhula,

Xu,

White

et al. 2024

Sci. Adv.

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Numerous technologies—with catalytic, therapeutic, and diagnostic applications—would benefit from improved chelation strategies for heavy alkaline earth elements: Ra 2+ , Ba 2+ , and Sr 2+ . Unfortunately, chelating these metals is challenging because of their large size and weak polarizing power. We found 18-crown-6-tetracarboxylic acid ( H 4 COCO ) bound Ra 2+ , Ba 2+ , and Sr 2+ to form M(H x COCO) x –2 . Upon isolating radioactive 223 Ra from its parent radionuclides ( 227 Ac and 227 Th), 223 Ra 2+ reacted with the fully deprotonated COCO 4− chelator to generate Ra(COCO) 2− ( aq ) (log K Ra(COCO)2− = 5.97 ± 0.01), a rare example of a molecular radium complex. Comparative analyses with Sr 2+ and Ba 2+ congeners informed on what attributes engendered success in heavy alkaline earth complexation. Chelators with high negative charge [−4 for Ra(COCO) 2− ( aq ) ] and many donor atoms [≥11 in Ra(COCO) 2− ( aq ) ] provided a framework for stable complex formation. These conditions achieved steric saturation and overcame the weak polarization powers associated with these large dicationic metals.

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“…Subsequently, Corey et al have described a scanning method which utilizes a scaler with digital print-out rather than a count rate meter with digital and/or analog display on a photoscan (19). Sklaroff and Charkes have recently described the use of the photoscan for the detection of metastatic cancer to bone and have demonstrated that early lesions (prior to observable roentgenographic changes) can be detected by this method (20). Existing commercial equipment was utilized, and bone biopsies were obtained in several cases to establish the validity of the technique.…”

Section: Introductionmentioning

confidence: 99%

Establishing a Clinical Role for Bone Scans (perspective on “Early Diagnosis of Metastatic Bone Cancer by Photoscanning with Strontium-85” J Nucl Med. 1964;5:168–179)

Strauss

2020

J Nucl Med

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Studies of Metastatic Bone Lesions with Strontium 85

Cited by 28 publications

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Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Advances in heavy alkaline earth chemistry provide insight into complexation of weakly polarizing Ra ²⁺ , Ba ²⁺ , and Sr ²⁺ cations

Establishing a Clinical Role for Bone Scans (perspective on “Early Diagnosis of Metastatic Bone Cancer by Photoscanning with Strontium-85” J Nucl Med. 1964;5:168–179)

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Studies of Metastatic Bone Lesions with Strontium 85

Cited by 28 publications

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Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Evaluation of osteoblastic activity around dental implants using bone scintigraphy

Advances in heavy alkaline earth chemistry provide insight into complexation of weakly polarizing Ra 2+ , Ba 2+ , and Sr 2+ cations

Establishing a Clinical Role for Bone Scans (perspective on “Early Diagnosis of Metastatic Bone Cancer by Photoscanning with Strontium-85” J Nucl Med. 1964;5:168–179)

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Advances in heavy alkaline earth chemistry provide insight into complexation of weakly polarizing Ra ²⁺ , Ba ²⁺ , and Sr ²⁺ cations