Diagnosis of Bone Metastasis by Photoscanning With Strontium 85

Dm, Sklaroff; Nd, Charkes

doi:10.1001/jama.1964.03060270007001

Cited by 33 publications

(5 citation statements)

References 5 publications

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“…The IBS can be used to evaluate whole-body isotope retention and kinetics and may be able t o resolve this problem. Although the particular counter used in this study is not available elsewhere, the development of similar procedures using single or multiple probe counters is feasible (Sklaroff and Charkes, 1964). The use of noncollimated crystals greatly enhances sensitivity, although definition is lost.…”

Section: Discussionmentioning

confidence: 99%

“…Bone scanning as an adjunct in early cancer detection is a well-established useful clinical procedure (Bauer and Wendeberg, 1959;Kofman et al, 1963;Sklaroff and Charkes, 1964;Rosenthall, 1965;DeNardo, 1966). However, as Weber et al (1968) have pointed out, obtaining bone scintiscans using the strontium-85tracer is a tedious procedure requiring long periods of scanning and, occasionally, repeated scanning.…”

Section: Introductionmentioning

confidence: 99%

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Use of a whole‐body counter in bone scanning

Gardner

Johnston

1969

Journal of Surgical Oncology

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A new method of whole-body assay for abnormal concentration of bone-seeking radioactive isotopes, in this instance SrS5, has been performed in 40 patients with excellent results. The instrument used is a whole-body counter which employs 18 NaI (Tl) crystals (9 by 2 in.) in a 3 x 6 array which permits bilateral comparisons of isotope concentration. crystal-to-crystal comparisons, and body area comparisons. Very small amounts of isotope (1-10 pc, Sr") are required. In 40 patients, one false positive and no false negative findings were obtained. The findings were confirmed by scintiscanning and X-ray studies.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Use of a whole‐body counter in bone scanning

Gardner

Johnston

1969

Journal of Surgical Oncology

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“…Bone agents, such as 99"Tc-MDP, fail to accumulate in purely osteolytic bony metastases. Since the biodistribution of strontium [7] is similar to %"TC-MDP, one can suspect strontium-89 will not concentrate, and thus will be ineffective in purely osteolytic metastases. A lytic lesion is seen on a radiograph when the osteoclastic activity is greater than the osteoblastic activity [8].…”

Section: Disc U Ssi 0 Nmentioning

confidence: 99%

Pain palliation with strontium-89 in children with metastatic disease

Charron

Brown

Rowland

et al. 1996

Med. Pediatr. Oncol.

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We report two cases of children with metastatic bone disease who received strontium‐89 intravenously. An 11‐year‐old boy with stage IV neuroblastoma received 50 μCi/kg of strontium‐89. He had a good response, and his pain abated to the point that he could be taken off IV Dilaudid and was discharged from the hospital. A 7‐year‐old girl with the diagnosis of squamous cell carcinoma of the lung disclosed minimal increased uptake on a bone scan. Following the strontium‐89 therapy, she did not have any significant improvement in pain, probably due to the minimal osteoblastic activity evidenced by the minimal abnormalities on the bone scan. Until this report there has been no reported case of using strontium‐89 in the treatment of children with metastatic disease. © 1996 Wiley‐Liss, Inc.

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“…On the scintogram, metastatic lesions show an increased uptake of strontium 85 when there is an increased rate of calcium accretion. However, a rapidly proliferating tumor producing osteolysis may give an entirely normal picture (3). Interpretation of the scintiscan, therefore, must be based on the clinical findings.…”

Section: Scintillation Scanning (Strontium85) Of Bonementioning

confidence: 99%

Use of Isotopes for Demonstration of Lesions in Joints and Bones as an Aid in Differential Diagnosis

Strasser

Thrift

1968

J American Geriatrics Society

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Scintillation scans of the joints were obtained after intravenous injection of radioiodine in patients with rheumatoid arthritis, lupus, scleroderma, gout and osteoarthritis. Distinct radioactivity (correlated with the severity of the disorder) was observed in the first four diseases, but not in osteoarthritis. In a 72‐year‐old man with prostatic carcinoma and back pain, x‐ray examination of the lumbar region failed to reveal metastases, whereas they were indicated by strontium85 scanning of that area and confirmed at autopsy. Thus scintillation scanning after the injection of a suitable isotope can be of value in differential diagnosis and in estimating the severity of disease. However, the scan must always be interpreted in the light of the clinical situation.

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Diagnosis of Bone Metastasis by Photoscanning With Strontium 85

Cited by 33 publications

References 5 publications

Use of a whole‐body counter in bone scanning

Use of a whole‐body counter in bone scanning

Pain palliation with strontium-89 in children with metastatic disease

Use of Isotopes for Demonstration of Lesions in Joints and Bones as an Aid in Differential Diagnosis

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