A Critical Analysis of the Long-Term Impact of Radical Prostatectomy on Cancer Control and Function Outcomes

Application of Erection Hardness Score as a Diagnostic Tool to Assess Erectile Function Recovery after Robot-Assisted Radical Prostatectomy

“…Because of the very small number of patients in this series, we assessed the impact of just a few parameters on EF recovery using the Cox model for proportional hazard regression, and we found that the age, preoperative outcome of IIEF-5 and the nerve preservation procedure are independent predictors of EF recovery . These results are consistent with those of previous studies identifying parameters to predict potency recovery [4,5,[12][13][14]. For example, Ficarra et al reported that age, preoperative outcome of IIEF-5, concomitant illness and choice of nerve preservation techniques were the most appropriate predictors of RARP recovery [4].…”

“…Although significant advances have been made in recent years in exploring pelvic anatomy and the advancement of surgical techniques [3], RARP is still often accompanied by several types of postoperative adverse events such as incontinence and erectile dysfunction [3,4]. This has a negative impact on the postoperative quality of life of patients undergoing RARP [5].…”

Regulation of vascular endothelial growth factor in prostate cancer

“…Indeed, it is currently not possible to accurately distinguish high-risk prostate tumors, which require extensive therapeutic intervention, from low-risk indolent tumors, many of which do not require any therapy (Draisma et al 2009, Cuzick et al 2014, Tombal et al 2014, Weiner et al 2015. Therefore, most men with clinically localized PCa undergo radical prostatectomy or radiotherapy with curative intent (Boorjian et al 2012, Heidenreich et al 2014). Yet, it has been estimated that between 20 and 30% of cases will experience recurrence (Boorjian et al 2012).…”

“…Therefore, most men with clinically localized PCa undergo radical prostatectomy or radiotherapy with curative intent (Boorjian et al 2012, Heidenreich et al 2014). Yet, it has been estimated that between 20 and 30% of cases will experience recurrence (Boorjian et al 2012). Following local recurrence and metastasis, androgen deprivation therapy (ADT), which is achieved medically or through orchiectomy, is typically effective for !24 months, by which time progression to the more detrimental form of castrateresistant PCa (CRPC) is common .…”

The CPC Risk Calculator: A New App to Predict Prostate-specific Antigen Recurrence During Follow-up After Radical Prostatectomy

“…However, the evidence for rational use of the PSA test (ie, the frequency and total length of follow-up) following RP is limited and is primarily based on empiric and untested dogmas. It is well established that a large proportion of patients undergoing RP remain without BR even after long-term follow-up [22,23]. Nonetheless, prediction of BR at an individual Surgical margin R− Surgical margin R+ …”