A Critical Review on Breast Cancer Literature: Screening, Awareness and Preventive Measures

Swapana, M.; Padmavathy, C.

doi:10.5901/mjss.2015.v6n4s3p256

Cited by 8 publications

(7 citation statements)

References 75 publications

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“…Our preliminary studies on major constituents of C. limon lyophilized pure fruit juice powder confirm that phytochemicals are important constituents and they possess anti-cancer and anti-apoptotic activity. Similar results were also recorded which were followed by the author [89].…”

Section: Ft-ir Spectral Analysissupporting

confidence: 79%

Phytochemical Profiling and Anti-cancer Study of Lyophilized Pure Fruit Juice of Citrus Limon (L.) Osbeck against Human Breast Cancer (MCF-7) Cell Line

A.¹,

Sivakumari²,

Ashok³

et al. 2017

JAMB

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Abstract. The present study aims at the phytochemical profiling of lyophilized pure fruit juice powder of Citrus limon and demonstrates its efficacy as an antitumor agent against human breast cancer cell line (MCF-7). The cytotoxicity was evaluated using the changes in cell morphology, cell viability, and DNA fragmentation, the percentage of cell viability was determined by MTT assay. Our results showed that lyophilized pure fruit juice powder of Citrus limon inhibited the proliferation of human breast cancer cell line MCF-7 with an IC50 98.16 μg/ml at 48 h incubation, it was shown to promote apoptosis as seen as DNA fragmentation using ladder assay. These results suggest that lyophilized pure fruit juice powder of Citrus limon has antiproliferative effect against MCF-7 cell by suppressing its growth.

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Section: Ft-ir Spectral Analysissupporting

confidence: 79%

Phytochemical Profiling and Anti-cancer Study of Lyophilized Pure Fruit Juice of Citrus Limon (L.) Osbeck against Human Breast Cancer (MCF-7) Cell Line

A.¹,

Sivakumari²,

Ashok³

et al. 2017

JAMB

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“…2,3 Surgical removal of the cancerous cells are normally followed by a round of chemotherapy or radiotherapy in order to lower the expectancy of tumor metastasis. 4 Doxorubicin (DOX) is an approved chemotherapeutic drug for the treatment of lung, breast, ovarian, and acute lymphoblastic leukaemia. 5 However, clinical application of DOX is hindered by its dose-dependent non-site-specific toxicity, such as cardio-toxicity and prevalence of off target effects.…”

Section: Introductionmentioning

confidence: 99%

Poly(vinyl alcohol) and Functionalized Ionic Liquid-Based Smart Hydrogels for Doxorubicin Release

Kuddushi

Ray

Aswal

et al. 2020

ACS Appl. Bio Mater.

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Limitations associated with the traditional cancer therapies prompt the scientific community to develop an effective, safer, smarter and targeted drug carriers that improve the efficiency of the drug carrier, reduce the adverse effects of the drug on the healthy cells, and helps in preventing the cancer recurrences. This research aims to design a stimuli-responsive, self-healable, adhesive, and injectable polymeric hydrogel with ester functionalized ionic liquid (ILs) as one of the additives to improve the efficiency of the anti-cancer drug in encapsulation and localized delivery. The designed polymeric hydrogel responds to intracellular biological stimuli (e.g. acidic pH of cancerous cells and temperature), change the morphology through changing the shape and size of the gelator within the hydrogel matrix and release the encapsulated doxorubicin (DOX) at the tumor site efficiently. Molecular interactions, gel morphology, and mechanical strength of the hydrogel were characterized through various analytical techniques, including small angle neutron scattering (SANS). Adhesive properties of the polymeric hydrogel were measured by lap-shear strength tests and biocompatibility and cellular drug uptake study on human breast cancer (MCF-7) and human cervical carcinoma cells (HeLa). The in-vitro cytotoxicity and drug release study showed that the hybrid hydrogel is more effective at killing the cancerous cells, and the targeted release of the DOX occurred at intracellular acidic pH. The polymeric hydrogel provides an efficient therapeutic approach for the encapsulation and release of the drug. Overall, the study offers a proof of 2 | P a g e concept to test the feasibility of the hydrogel system whether the hydrogel formulation helped or hindered the total cellular DOX trafficking.

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“…The PLGA-PEG-PLGA triblock copolymers were analyzed using 1 H NMR to find out the structure and composition. All the data were noted at 300 MHz on a BRUKER AV-300 spectrometer at 25 C using deuterated chloroform (CDCl 3 ) as a solvent and tetramethyl silane (TMS) as an internal standard [28] The characterization of the functional groups of PLGA-PEG-PLGA triblock copolymers was carried out by Fourier transform infrared (FT-IR) analysis using Perklin Elmer 2400 II (USA) FTIR spectroscopy.…”

Section: Synthesis and Characterization Of The Copolymermentioning

confidence: 99%

“…Liposomes were dissolved in 10% Triton X-100 for measurement of DOX content by UV-Vis spectrophotometry at 480 nm. The entrapment efficiency (EE) was calculated as Equation (1).…”

Section: Preparation and Characterization Of Liposomesmentioning

confidence: 99%

“…Breast cancer is positioned as the first among all cancer diseases identified in females. And, a lot of research is conducted every year to discover proper medication method [1,2]. For now, in clinic, nearly all females who are diagnosed with breast tumour will adopt the lumpectomy surgery to get rid of the maximum amount of cancerous tissues.…”

Section: Introductionmentioning

confidence: 99%

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Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer

Cao

Zhang

Akabar

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

101

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The aim of this research is to utilize a hybrid system of liposomal doxorubicin (DOX-Lip) loaded thermogel (DOX-Lip-Gel) to realize the steady sustained delivery of doxorubicin (DOX), a small hydrophilic drug, for the treatment of breast cancer locally. Herein, liposomal doxorubicin was prepared via the traditional film dispersion method with the particle size of 75 nm and drug entrapment efficiency of 86%. And, the triblock copolymer of poly (D, L-lactide-co-glycolide)-b-poly (ethylene glycol)-b-poly (D, L-lactide -co-glycolide) (PLGA-PEG-PLGA) was synthesized via ring-opening polymerization to prepare the thermosensitive hydrogel through dissolving the polymers in DOX-Lip solution. The liposome loaded hydrogel was in a sol state at room temperature and converted into the gel state at body temperature and would degrade gradually during the time in vivo. The drug release of DOX out of DOX-Lip-Gel could be in a steady sustained manner up to 11 days without significant burst release as compared to that of DOX-loaded hydrogel (DOX-Gel). An orthotopic breast cancer model was adopted to evaluate the in vivo antitumor efficacy. And, the results revealed DOX-Lip-Gel had better antitumor efficiency as well as lower side effects.

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A Critical Review on Breast Cancer Literature: Screening, Awareness and Preventive Measures

Abstract: Abstract

Cited by 8 publications

References 75 publications

Phytochemical Profiling and Anti-cancer Study of Lyophilized Pure Fruit Juice of Citrus Limon (L.) Osbeck against Human Breast Cancer (MCF-7) Cell Line

Phytochemical Profiling and Anti-cancer Study of Lyophilized Pure Fruit Juice of Citrus Limon (L.) Osbeck against Human Breast Cancer (MCF-7) Cell Line

Poly(vinyl alcohol) and Functionalized Ionic Liquid-Based Smart Hydrogels for Doxorubicin Release

Liposomal doxorubicin loaded PLGA-PEG-PLGA based thermogel for sustained local drug delivery for the treatment of breast cancer

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