A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

Chaudhary, Kajal; Parihar, Shweta; Sharma, Devender

doi:10.22270/jddt.v11i6.5030

Cited by 12 publications

(7 citation statements)

References 66 publications

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“…The drug delivery through the hybrid Nanoparticle has been dominated by the delivery of various drugs; here we are focus on the delivery of the anticancer drug. The multidrug-resistant are present in the cancer cells that are challenging to the delivery of the chemotherapeutic agent to the cells [41][42][43] .…”

Section: Drug Deliverymentioning

confidence: 99%

Lipid-Polymer Hybrid Nanoparticles for Topical Drug Delivery System

Miri¹,

Jangde

Singh

et al. 2023

J. Drug Delivery Ther.

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Human skin not only functions as a permeation barrier (mainly due to the stratum corneum layer), but also provides a unique delivery pathway for therapeutic and other active agents. These compounds penetrate via intercellular, intracellular and transappendageal routes, resulting in topical delivery (into skin strata) and transdermal delivery (to subcutaneous tissues and into the systemic circulation). Lipid–polymer hybrid nanoparticles (LPHNPs) are next-generation core–shell nanostructures, conceptually derived from both liposome and polymeric nanoparticles (NPs), where a polymer core remains enveloped by a lipid layer. Although they have garnered significant interest, they remain not yet widely exploited or ubiquitous. Recently, a fundamental transformation has occurred in the preparation of LPHNPs, characterized by a transition from a two-step to a one-step strategy, involving synchronous self-assembly of polymers and lipids. Owing to its two-in-one structure, this approach is of particular interest as a combinatorial drug delivery platform in oncology. In particular, the outer surface can be decorated in multifarious ways for active targeting of anticancer therapy, delivery of DNA or RNA materials, and use as a diagnostic imaging agent. Keywords: Lipid–polymer hybrid nanoparticle, Topical delivery, Drug delivery, Gene delivery.

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Section: Drug Deliverymentioning

confidence: 99%

Lipid-Polymer Hybrid Nanoparticles for Topical Drug Delivery System

Miri¹,

Jangde

Singh

et al. 2023

J. Drug Delivery Ther.

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“…Examples of Nanoparticle medications include vaccines and cancer treatments for metastatic brain tumours. 23 Additionally, the application of nanoparticles for oral and ophthalmic administration was studied concurrently. 24 Advantages of nanoparticles-Some advantages like 25  It is simple to alter the surface characteristics and size of nanoparticles to accomplish active and passive targeting.…”

Section: B Colloidal Techniques-mentioning

confidence: 99%

Brain-Targeted Drug Delivery System: A Novel Approach

Chahar¹,

Tiwari²,

Malik³

et al. 2022

J. Drug Delivery Ther.

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A targeted drug delivery system is based on a technique that continuously administers a predetermined dosage of a therapeutic agent to a sick location of the body. The targeted drug delivery goal is to raise the relative amount of the treatment in the target tissues while lowering it in the non-target tissues. This technique's intrinsic benefit has been reduced drug dose and adverse effects. Drug targeting in the brain is one of the most challenging issues in pharmaceutical research because the blood-brain barrier acts as an impermeable barrier for systemically delivered therapeutics and the brain extracellular matrix contributes to the poor distribution of locally delivered drugs. In the treatment of various Central nervous system (CNS) diseases, general approaches that can improve drug delivery to the brain are of great interest. Drugs are less harmful and more effective when they are administered close to where they would be most effective. Extreme research studies have recently concentrated on the development of fresh strategies for more successfully delivering medications to the brain in response to the shortcomings of the traditional delivery mechanism. This study thoroughly explains the obstacles involved in brain-targeted drug delivery, the process of drug transfer through Blood Brain Barrier, different techniques for brain-targeted drug delivery, and some recent breakthroughs in brain-targeted drug delivery. Keywords: Blood-brain barrier, Brain-targeted, Cerebrospinal fluid, Nanoparticles, Liposomes, Convection-enhanced drug delivery.

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“…Thus, to carry the hydrophilic charged molecules, such as proteins, peptides, and nucleic acids, these blocks are switched to allow interactions in the core and neutralize the charge 58 . The advantages of the higher thermodynamic stability and the smaller volume make the PNPs a suitable drug carrier with good endothelial cell permeability while avoiding kidney rejection [61][62][63][64] . The hydrophobic macromolecules and drugs can be transferred to the center of the PNPs, hence, the injection of PNPs suspension after being separated in an aqueous solution could achieve therapeutic effect 65 .…”

Section: Polymeric Micellesmentioning

confidence: 99%

A Review on Nanotechnology in Cancer Diagnosis and Therapy: it’s Application

Purohit¹,

Soni²,

Thakur³

et al. 2022

Int J Med Sci Pharm Res

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Cancer is a leading cause of death and poor quality of life globally. Even though several strategies are devised to reduce deaths, reduce chronic pain and improve the quality of life, there remains a shortfall in the adequacies of these cancer therapies. Among the cardinal steps towards ensuring optimal cancer treatment are early detection of cancer cells and drug application with high specificity to reduce toxicities. Due to increased systemic toxicities and refractoriness with conventional cancer diagnostic and therapeutic tools, other strategies including nanotechnology are being employed to improve diagnosis and mitigate disease severity. Over the years, immunotherapeutic agents based on nanotechnology have been used for several cancer types to reduce the invasiveness of cancerous cells while sparing healthy cells at the target site. Nanomaterials including carbon nanotubes, polymeric micelles and liposomes have been used in cancer drug design where they have shown considerable pharmacokinetic and pharmacodynamic benefits in cancer diagnosis and treatment. In this review, we outline the commonly used nanomaterials which are employed in cancer diagnosis and therapy. We have highlighted the suitability of these nanomaterials for cancer management based on their physicochemical and biological properties. We further reviewed the challenges that are associated with the various nanomaterials which limit their uses and hamper their translatability into the clinical setting in certain cancer types. Keywords: Nanomaterials, Nanotechnology, Cancer, Diagnosis, Treatment.

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A Critical Review on Nanoscience Advancement: In Treatment of Viral Infection

Cited by 12 publications

References 66 publications

Lipid-Polymer Hybrid Nanoparticles for Topical Drug Delivery System

Lipid-Polymer Hybrid Nanoparticles for Topical Drug Delivery System

Brain-Targeted Drug Delivery System: A Novel Approach

A Review on Nanotechnology in Cancer Diagnosis and Therapy: it’s Application

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