2017
DOI: 10.3390/ijms18081784
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A Critical Review on the Effect of Docosahexaenoic Acid (DHA) on Cancer Cell Cycle Progression

Abstract: Globally, there were 14.1 million new cancer diagnoses and 8.2 million cancer deaths in 2012. For many cancers, conventional therapies are limited in their successes and an improved understanding of disease progression is needed in conjunction with exploration of alternative therapies. The long chain polyunsaturated fatty acid, docosahexaenoic acid (DHA), has been shown to enhance many cellular responses that reduce cancer cell viability and decrease proliferation both in vitro and in vivo. A small number of s… Show more

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Cited by 95 publications
(59 citation statements)
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“…An epidemiological survey tracking more than 72,000 female participants and their diets over an average duration of 8 years indicated that individuals consuming higher amounts of n-6 PUFAs relative to n-3 faced increased risks of developing breast cancer [49]. These trends in a large cohort were consistent with previous assessments of the beneficial properties of the n-3 PUFAs EPA [50][51][52] and DHA [53,54] in fighting various cancers. The beneficial properties of ALA (also n-3), however, is less established compared to EPA and DHA.…”
Section: Lipids As Suppressor Of Cancersupporting
confidence: 79%
“…An epidemiological survey tracking more than 72,000 female participants and their diets over an average duration of 8 years indicated that individuals consuming higher amounts of n-6 PUFAs relative to n-3 faced increased risks of developing breast cancer [49]. These trends in a large cohort were consistent with previous assessments of the beneficial properties of the n-3 PUFAs EPA [50][51][52] and DHA [53,54] in fighting various cancers. The beneficial properties of ALA (also n-3), however, is less established compared to EPA and DHA.…”
Section: Lipids As Suppressor Of Cancersupporting
confidence: 79%
“…DHA is found in fish oil from several species as widely reported in the literature 22 . DHA has been reported to be active against breast (MDA-MB-231, MCF-7), pancreatic (MiaPaca-2) and colorectal (CaCo-2, SW-620) cancer cell lines at a range of concentrations between 10 and 100 µM 26 .…”
Section: Resultsmentioning
confidence: 99%
“…In other studies, It has shown that microtubule binding plays a role in the development of acute myeloid leukemia cells and the biology of colorectal cancer cells [18,19]. The change of cell cycle is the cause of abnormal proliferation of many tumor cells [20,21].…”
Section: Discussionmentioning
confidence: 99%