A critical review on the association of hyposalivation and dental caries in children and adolescents

Letieri, Aline dos Santos; Siqueira, Walter L.; Solon-de-Mello, Monique; Ferreira, Daniele Masterson Tavares Pereira; Freitas-Fernandes, Liana Bastos; Valente, Ana Paula; Souza, Ivete Pomarico Ribeiro de; Fidalgo, Tatiana Kelly da Silva; Maia, Lucianne Cople

doi:10.1016/j.archoralbio.2022.105545

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Consequently, reduced salivary ow can diminish the preventive capacity of saliva [21,23]. However, a recent review recognized that there is a need to design further studies to make a reliable assessment between hyosalivation and dental caries in young patients [24].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Alkarad

Alkhouli

Dashash

2023

Preprint

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Objectives A double-blind randomized controlled clinical trial was undertaken to evaluate the efficacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in the remineralization of teeth of Syrian children aged 6-8 years enrolled in orphanage of the city of Damascus. Materials and Methods The study sample included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four time (T0, T1, T2, and T3) to measure the pH of saliva and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate and salivary pH. However, there was significant difference between different time points in the mean value of salivary pH and salivary flow rate. Conclusion The GC Tooth Mouse (CPP-ACP) is not superior to placebo mousse at tooth remineralization according to salivary pH measure and the rate of salivary flow. Further studies are still essential to assertion findings. Trial registration: ISRCTN17509082, Registration date 22/11/2022

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Section: Discussionmentioning

confidence: 99%

Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Alkarad

Alkhouli

Dashash

2023

Preprint

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“…In situ, saliva plays an essential role in the prevention of dental caries [5,6]. Notably, saliva is crucial for oral health in general as it plays a role in various processes including digestion, microbial homeostasis, taste perception, wound healing, regulation of the water balance, moisturizing, and lubrication of the oral surfaces [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

“…Saliva protects against dental caries in several ways, such as clearance of food debris and sugar, aggregation and killing of cariogenic bacteria, acid neutralization, maintaining supersaturation with respect to tooth mineral, participation in formation of the acquired pellicle, and antimicrobial defence [11]. So, due to reduced antimicrobial, buffering, and cleansing properties of saliva in patients suffering from hyposalivation the incidence of dental caries increases drastically [6]. To exemplify, a 75% higher plaque index in patients suffering from hyposalivation has been reported [5,17].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Correlation between Salivary Spinnbarkeit and Caries Scores

Faruque,

Taidouch,

Bikker

et al. 2024

Caries Res

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Introduction: In this study, the relationship between the spinnbarkeit, i.e., the stretchability of saliva, and dental caries was investigated. Methods: Dentistry students were divided into a group with more than 2 decayed, missed, and filled teeth (DMFT ≥2, n = 30) and caries-free group (DMFT = 0, n = 36). Results: Unstimulated saliva flow rate, pH, and spinnbarkeit were determined. Salivary spinnbarkeit was significantly lower in the caries-prone group compared to the caries-free group (5.4 ± 3.9 mm vs. 13.5 ± 7.6 mm, respectively, p < 0.001). Conclusion: This suggests that saliva with high spinnbarkeit protects better against dental caries.

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“…Consequently, reduced salivary flow can diminish the preventive capacity of saliva [14,15]. However, a recent review recognized that there is a need to design further studies to make a reliable assessment between hyposalivation and dental caries in young patients [16]. Prathima et al study (2021) showed that maximum peak rise in salivary pH was observed immediately after spitting the CPP-ACP containing gums [17].…”

Section: Introductionmentioning

confidence: 99%

Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

2023

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Aim To investigate the changes of salivary flow rate and salivary pH of Syrian children with mixed dentition following application of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP). Methods This study is part of a double-blind randomized controlled clinical trial. It included 50 children aged 6–8 who were randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 min, saliva samples were collected four times (T0, T1, T2, and T3) to measure salivary pH and the rate of salivary flow. Results There was no significant difference between group A and B in the mean value of salivary flow rate (t = 1.08, P = 0.28, 0.57 ± 0.28 versus 0.56 ± 0.38 respectively) and salivary pH (t = 0.61, P = 0.54, 7.28 ± 0.44 versus 7.25 ± 0.36 respectively). However, there was a significant difference between different time points (T0, T1, T2, and T3) in the mean value of salivary flow rate (0.41 ± 0.30, 0.65 ± 0.36, 0.53 ± 0.28, and 0.56 ± 0.34 respectively) and salivary pH (6.99 ± 0.44, 7.46 ± 0.36, 7.36 ± 0.32, and 7.26 ± 0.32 respectively). Conclusion The application of the GC Tooth Mouse (CPP-ACP) was similar to placebo in increasing the salivary pH and salivary flow rate. Trial registration ISRCTN17509082, Registration date 22/11/2022.

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A critical review on the association of hyposalivation and dental caries in children and adolescents

Cited by 10 publications

References 35 publications

Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Efficacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children- results of a double -blind, randomized controlled clinical trial

Exploring the Correlation between Salivary Spinnbarkeit and Caries Scores

Remineralization of teeth with casein phosphopeptide-amorphous calcium phosphate: analysis of salivary pH and the rate of salivary flow

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