2022
DOI: 10.1155/2022/7702512
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A Critical Scrutiny on Liposomal Nanoparticles Drug Carriers as Modelled by Topotecan Encapsulation and Release in Treating Cancer

Abstract: The medical field is looking for drugs and/or ways of delivering drugs without harming patients. A number of severe drug side effects are reported, such as acute kidney injury (AKI), hepatotoxicity, skin rash, and so on. Nanomedicine has come to the rescue. Liposomal nanoparticles have shown great potential in loading drugs, and delivering drugs to specific targeted sites, hence achieving a needed bioavailability and steady state concentration, which is achieved by a controlled drug release ability by the nano… Show more

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Cited by 2 publications
(2 citation statements)
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“…Due to less gastric residence time, the active lactone ring will rapidly have converted to an inactive carboxylate form, reducing the bioavailability of topotecan. Along with the ring conversion, there is another obstacle to the bioavailability of TPT, i.e., the hydrophilic nature of the drug [5]. The cancer-treating drug TPT needs to act on the tumour tissues by permeating deep into them, but the negative logP value of TPT doesn't allow it to do this.…”
Section: Introductionmentioning
confidence: 99%
“…Due to less gastric residence time, the active lactone ring will rapidly have converted to an inactive carboxylate form, reducing the bioavailability of topotecan. Along with the ring conversion, there is another obstacle to the bioavailability of TPT, i.e., the hydrophilic nature of the drug [5]. The cancer-treating drug TPT needs to act on the tumour tissues by permeating deep into them, but the negative logP value of TPT doesn't allow it to do this.…”
Section: Introductionmentioning
confidence: 99%
“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”
mentioning
confidence: 99%