Synergetic effect is a special gas discharge phenomenon among insulating gas mixtures, which has important reference value for gas selection of future gasinsulated power equipment. The research progress and investigation methods of synergistic effect and insulation characteristics of different gas mixtures at home and abroad are reviewed in this chapter. The synergistic effect between different kinds of gas mixtures including SF 6 gas mixtures and some new insulation gases such as cC 4 F 8 , CF 3 I, and C 4 F 7 N is presented. Combined with the results of multiple studies, it can be seen that the synergistic effect of the gas mixture has a certain relationship with the electronic transport parameters and discharge patterns. Besides, the synergistic effect of the same gas mixture may change with the change of external conditions such as gas pressure, voltage type, and electrode distance.