Background: Saudi Arabia is developing very fast in all disciplines, especially in nursing and health. Work environments involve essential factors that organisations must consider when seeking to understand the performance of employees at work. Understanding the effect of the work environment on nurses’ job performance could lead to many benefits for leaders, nurses, and health organisations. The nursing shortage is a pressing concern around the world. A high turnover of skilled nurses can have serious implications for the quality of care, cost, and efficiency of hospitals. Improving nurses' working conditions should be essential to address the nursing shortage. Aim: To determine the effect of the Work Environment on Nurses’ Job Performance. Method: This is a systematic review with a quantitative approach. The review followed the Preferred Reporting Items for Systematic Reviews. Our research team developed a study plan before initiating the literature search. In this plan, the search was refined to include only English-language articles published between 2017 and 2021. This search provided 58 applicable studies (MEDLINE: 13, Scopus: 19, ScienceDirect: 21, and PubMed: 5) related to the PICO question and limited to nursing.