A cross-sectional assessment of the prevalence of multiple chronic conditions and medication use in a sample of community-dwelling adults with fibromyalgia in Olmsted County, Minnesota

Vincent, Ann; Whipple, Mary O.; McAllister, Samantha J.; Aleman, Katherine M; Sauver, Jennifer L. St.

doi:10.1136/bmjopen-2014-006681

Cited by 48 publications

(47 citation statements)

References 18 publications

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“…It is commonly associated with a variety of comorbidities, including, but not limited to, migraines and sleep difficulties,2,3 and also with mental health conditions, such as anxiety and depression 4. Recently, in Japan, the prevalence of fibromyalgia was estimated to be 2.1% among adults (aged ≥20 years), with the majority (60.5%) of them being female 5…”

Section: Introductionmentioning

confidence: 99%

Humanistic and economic burden of fibromyalgia in Japan

Lee

Ebata

Hlavacek

et al. 2016

JPR

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PurposeThe aim of this study was to examine the health and economic burden associated with fibromyalgia among adults in Japan.Materials and methodsData from the 2011–2014 Japan National Health and Wellness Survey (n=115,271), a nationally representative survey of adults, were analyzed. The greedy matching algorithm was used to match the respondents who self-reported a diagnosis of fibromyalgia with those not having fibromyalgia (n=256). Generalized linear models, controlling for covariates (eg, age and sex), examined whether the respondents with fibromyalgia differed from matched controls based on health status (health utilities; Mental and Physical Component Summary scores from Medical Outcomes Study: 12-item Version 2 and 36-item Version 2 Short Form Survey), sleep quality (ie, sleep difficulty symptoms), work productivity (Work Productivity and Activity Impairment Questionnaire – General Health Version 2.0), health care resource use, and estimated annual indirect and direct costs (based on published annual wages and resource use events) in Japanese yen (¥).ResultsAfter adjustment for covariates, respondents with fibromyalgia relative to matched controls scored significantly lower on health utilities (adjusted means =0.547 vs 0.732), Mental Component Summary score (33.15 vs 45.88), and Physical Component Summary score (39.22 vs 50.81), all with P<0.001; these differences exceeded the clinically meaningful levels. In addition, those with fibromyalgia reported significantly poorer sleep quality than those without fibromyalgia. Respondents with fibromyalgia compared with those without fibromyalgia experienced significantly more loss in work productivity and health care resource use, resulting in those with fibromyalgia incurring indirect costs that were more than twice as high (adjusted means =¥2,826,395 vs ¥1,201,547) and direct costs that were nearly six times as high (¥1,941,118 vs ¥335,140), both with P<0.001.ConclusionJapanese adults with fibromyalgia experienced significantly poorer health-related quality of life and greater loss in work productivity and health care use than those without fibromyalgia, resulting in significantly higher costs. Improving the rates of diagnosis and treatment for this chronic pain condition may be helpful in addressing this considerable humanistic and economic burden.

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Section: Introductionmentioning

confidence: 99%

Humanistic and economic burden of fibromyalgia in Japan

Lee

Ebata

Hlavacek

et al. 2016

JPR

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“…Drugs for treating NS comorbidities, migraines, dizziness, gastric protectors and the use of analgesics were more common in patients with FM, as described in previous studies [7], but these clinical conditions are also commonly present in many patients without FM.…”

Section: Discussionmentioning

confidence: 78%

“…Separate treatment of clinical manifestations does not guarantee an improvement in the disease and may increase the risk of drug interactions and adverse events adding more clinical manifestations or aggravating them [7]. Some studies have shown that some clinical manifestations such as dizziness—a common symptom in patients with FM—are positively correlated with the number of consumed drugs [20].…”

Section: Discussionmentioning

confidence: 99%

“…Managing this situation effectively requires a multidisciplinary approach for treating all the problems together rather than separately. A recent study [7] describes the problem of multiple clinical conditions in FM with seven or more chronic conditions in each patient. The study also highlights the risk of polypharmacy and the possibility of an impairment of clinical symptoms due to drug interactions.…”

Section: Introductionmentioning

confidence: 99%

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Fibromyalgia is associated to receiving chronic medications beyond appropriateness: a cross-sectional study

Rivera

Vallejo

2016

Rheumatol Int

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The objectives of this study are to describe appropriateness and drug treatment of comorbidities in fibromyalgia (FM). Cross-sectional study of a group of patients. Number of drugs, indication, duration and appropriateness of prescriptions were evaluated. Patients were classified as: group 1, (FM/FM) previous FM diagnosis and fulfilling criteria; group 2, (noFM/noFM) other diagnosis and not fulfilling criteria; and group 3, (noFM/FM) other diagnosis but fulfilling criteria. Drugs were classified into drugs for nervous system, analgesics/NSAID and drugs for other comorbidities. Appropriateness was evaluated following clinical therapeutic guidelines. A total of 159 patients were included in the study and classified into group 1, with 59 patients; group 2, with 67 patients; and group 3, with 33 patients. Group 1 received a greater number of different drugs and for a longer period of time, there were less severe comorbidities and more unjustified treatments. No difference was found between the other two groups. Major opioids were only consumed in group 1. Also, in group 1, 45.8 % of patients were attended in psychiatry versus 15.6 % in group 3 and 3 % in group 2. The number of somatic symptoms correlated significantly with the number of drugs. Nervous system treatments were of shorter duration than other drug treatments. There was no difference in severe comorbidities. Comorbidities in FM are similar to those of other patients, but they receive more drugs and for a longer period of time. Drugs for nervous system comorbidities are introduced later, when other somatic symptoms are already treated. In patients with FM the treatments for mild comorbidities are not well justified.

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“…Individuals with chronic pain are known to be at increased risk of psychiatric disorders, particularly those involving low mood and anxiety [1][2][3] and Posttraumatic Stress Disorder (PTSD) [4,5]. Evidence shows that chronic pain sufferers with comorbid anxiety, depression, and PTSD present with greater levels of pain-related impairment, respond less well to pain focused treatment, and incur greater health costs [5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Posttraumatic Stress Disorder and Chronic Pain in People Seeking Treatment for Chronic Pain

Åkerblom

Perrin²,

Fischer

et al. 2018

The Clinical Journal of Pain

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Objectives: The symptoms of Posttraumatic Stress Disorder (PTSD) and chronic pain are thought to interact to increase the severity and impact of both conditions, but the mechanisms by which they interact remain unclear. This study examines the relationship between PTSD and chronic pain and whether indices of psychological flexibility mediate the relationship between these two conditions.Methods: Standardized self-report measures of PTSD, pain severity, pain interference, depression, and psychological flexibility (pain-related acceptance, committed action, cognitive fusion, and values-based action) were obtained from 315 people seeking treatment for chronic pain who also reported at least one traumatic experience.Results: People seeking treatment for chronic pain reporting symptoms consistent with a current diagnosis of PTSD had significantly higher levels of pain severity, pain interference, depression, and cognitive fusion and lower levels of pain-related acceptance and committed action than those reporting symptoms below diagnostic threshold for PTSD. Pain-related acceptance, committed action, cognitive fusion and depression mediated the relationship between PTSD and pain severity/interference, with pain-related acceptance being the strongest mediator from the psychological flexibility model.

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A cross-sectional assessment of the prevalence of multiple chronic conditions and medication use in a sample of community-dwelling adults with fibromyalgia in Olmsted County, Minnesota

Cited by 48 publications

References 18 publications

Humanistic and economic burden of fibromyalgia in Japan

Humanistic and economic burden of fibromyalgia in Japan

Fibromyalgia is associated to receiving chronic medications beyond appropriateness: a cross-sectional study

The Relationship Between Posttraumatic Stress Disorder and Chronic Pain in People Seeking Treatment for Chronic Pain

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