A Cross-Sectional Prevalence Study of Lumbar Disc Degeneration in a Working Population

Evans, W. T.; Jobe, William; Seibert, Charles E.

doi:10.1097/00007632-198901000-00012

Cited by 69 publications

(22 citation statements)

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“…Despite the extraordinary ability of MRI to delineate the spine, this study suggests that there is not a clear relationship between the MRI appearance and LBR This conclusion is supported by several other investigations [6,10,12,15,18,21]. The causes of LBP are numerous, diverse and poorly understood.…”

Section: Discussionmentioning

confidence: 46%

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The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males

1997

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The purpose of this study was to undertake a critical review of the potential role of magnetic resonance imaging (MRI) in the evaluation of low back pain (LBP) and to determine if there were differences in the MRI appearances between various occupational groups. The study group, 149 working men (78 aged 20-30 years and 71 aged 31-58 years) from five different occupations (car production workers, ambulance men, office staff, hospital porters and brewery draymen), underwent MRI of the lumbar spine. Thirty-four percent of the subjects had never experienced LBR Twelve months later, the examination was repeated on 89 men. Age-related differences were seen in the MRI appearances of the lumbar spine. Disc degeneration was most common at L5/S 1 and was significantly more prevalent (P < 0.01) in the older age group (52%) than in the younger age group (27%). Although LBP was more prevalent in the older subjects there was no relationship between LBP and disc degeneration. No differences in the MRI appearance of the lumbar spine were observed between the five occupational groups. Overall, 45% had 'abnormal' lumbar spines (evidence of disc degeneration, disc bulging or protrusion, facet hypertrophy, or nerve root compression). There was not a clear relationship between the MRI appearance of the lumbar spine and LBR Thirtytwo percent of asymptomatic subjects had 'abnormal' lumbar spines and 47% of all the subjects who had experienced LBP had 'normal' lumbar spines. During the 12-month follow-up period, 13 subjects experienced LBP for the first time. However, there was no change in the MRI appearances of their lumbar spines that could account for the onset of LBR Although MRI is an excellent technique for evaluating the lumbar spine, this study shows that it does not provide a suitable pre-employment screening technique capable of identifying those at risk of LBR

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Section: Discussionmentioning

confidence: 46%

“…A previous study [12] used MRI to compare the prevalence of disc disease in ambulatory and sedentary groups. It was found that ambulatory females had no degenerative discs and the sedentary group had a large number of degenerative discs.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males

1997

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“…4 There is strong evidence that, besides heredity, 5 mechanical factors such as overweight, occupational status, trauma, and immobilization may influence disc degeneration. [6][7][8][9][10][11][12] In basic research, a variety of different models have been established to study the biological effects of applied load on disc cells and their matrix metabolism. [13][14][15][16][17][18][19][20][21][22][23] They have shown that disc cells can respond to mechanical load depending on its pattern, for example, frequency and magnitude, with either cell death (necrosis or apoptosis), changes in gene expression (matrix genes, proteases, protein-inhibitors), and consecutive matrix production or degradation.…”

Section: Introductionmentioning

confidence: 99%

Influence of diurnal hyperosmotic loading on the metabolism and matrix gene expression of a whole‐organ intervertebral disc model

Haschtmann

Stoyanov

Ferguson

2006

Journal Orthopaedic Research

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It is generally agreed that the mechanical environment of intervertebral disc cells plays an important role in maintaining a balanced matrix metabolism. The precise mechanism by which the signals are transduced into the cells is poorly understood. Osmotic changes in the extracellular matrix (ECM) are thought to be involved. Current in-vitro studies on this topic are mostly short-term and show conflicting data on the reaction of disc cells subjected to osmotic changes which is partially due to the heterogenous and often substantially-reduced culture systems. The aim of the study was therefore to investigate the effects of cyclic osmotic loading for 4 weeks on metabolism and matrix gene expression in a full-organ intervertebral disc culture system. Intervertebral disc/endplate units were isolated from New Zealand White Rabbits and cultured either in iso-osmotic media (335 mosmol/kg) or were diurnally exposed for 8 hours to hyper-osmotic conditions (485 mosmol/kg). Cell viability, metabolic activity, matrix composition and matrix gene expression profile (collagen types I/II and aggrecan) were monitored using Live/Dead cell viability assay, tetrazolium reduction test (WST 8), proteoglycan and DNA quantification assays and quantitative PCR. The results show that diurnal osmotic stimulation did not have significant effects on proteoglycan content, cellularity and disc cell viability after 28 days in culture. However, hyperosmolarity caused increased cell death in the early culture phase and counteracted upregulation of type I collagen gene expression in nucleus and annulus cells. Moreover, the initially decreased cellular dehydrogenase activity recovered with osmotic stimulation after 4 weeks and aggrecan gene down-regulation was delayed, although the latter was not significant according to our statistical criteria. In contrast, collagen type II did not respond to the osmotic changes and was downregulated in both groups. In conclusion, diurnal hyper-osmotic stimulation of a whole-organ disc/ endplate culture partially inhibits a matrix gene expression profile as encountered in degenerative disc disease and counteracts cellular metabolic hypo-activity. ß

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“…Some studies have demonstrated associations between a history of sedentary work, low-back pain prevalence and degenerative changes of the intervertebral disc (Evans et al 1989, Videman et al 1990. It has been shown that sustained compression on the discs, as occurs during sitting, hampers¯uid¯ow into the disc (Kingma et al 2000), which consequently aOE ects disc nutrition adversely (Maroudas et al 1975, Holm et al 1981.…”

Section: Introductionmentioning

confidence: 99%

Effects of dynamic office chairs on trunk kinematics, trunk extensor EMG and spinal shrinkage

2001

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To cite this Article van DieËn, J. H. , De Looze, M. P. and Hermans, V. (2001) 'Effects of dynamic office chairs on trunk kinematics, trunk extensor EMG and spinal shrinkage ', Ergonomics, 44: 7,[739][740][741][742][743][744][745][746][747][748][749][750] To link to this Article: DOI: 10.1080/00140130120297 URL: http://dx.doi.org/10.1080/00140130120297Full terms and conditions of use: http://www.informaworld.com/terms-and-conditions-of-access.pdf This article may be used for research, teaching and private study purposes. Any substantial or systematic reproduction, re-distribution, re-selling, loan or sub-licensing, systematic supply or distribution in any form to anyone is expressly forbidden.The publisher does not give any warranty express or implied or make any representation that the contents will be complete or accurate or up to date. The accuracy of any instructions, formulae and drug doses should be independently verified with primary sources. The publisher shall not be liable for any loss, actions, claims, proceedings, demand or costs or damages whatsoever or howsoever caused arising directly or indirectly in connection with or arising out of the use of this material. Seated work has been shown to constitute a risk factor for low-back pain. This is attributed to the prolonged and monotonous low-level mechanical load imposed by a seated posture. To evaluate the potential health eOE ects with respect to the low back of o ce chairs with a movable seat and back rest, trunk kinematics, erector spinae EMG, spinal shrinkage and local discomfort were assessed in 10 subjects performing simulated o ce work. On three separate occasions subjects performed a 3 h task consisting of word processing, computer-aided design and reading. Three chairs were used, one with a ® xed seat and back rest and two dynamic chairs, one with a seat and back rest movable in a ® xed ratio with respect to each other, and one with a freely movable seat and back rest. Spinal shrinkage measurements showed a larger stature gain when working on the two dynamic chairs as compared with working on the chair with ® xed seat and back rest. Trunk kinematics and erector spinae EMG were strongly aOE ected by the task performed but not by the chair type. The results imply that dynamic o ce chairs oOE er a potential advantage over ® xed chairs, but the eOE ects of the task on the indicators of trunk load investigated were more pronounced than the eOE ects of the chair. EOE ects of dynamic o ce chairs on trunk kinematics

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A Cross-Sectional Prevalence Study of Lumbar Disc Degeneration in a Working Population

Cited by 69 publications

References 0 publications

The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males

The relationship between the magnetic resonance imaging appearance of the lumbar spine and low back pain, age and occupation in males

Influence of diurnal hyperosmotic loading on the metabolism and matrix gene expression of a whole‐organ intervertebral disc model

Effects of dynamic office chairs on trunk kinematics, trunk extensor EMG and spinal shrinkage

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