A Cross-sectional Study Examining the Risk Factors Associated with Lymphedema and its Prevalence in Breast Cancer Patients after Level 3 Axillary Lymph Node Dissection

Kibar, Sibel; Aras, Meltem; Delialioğlu, Sibel Ünsal; Köseoğlu, Belma Füsun

doi:10.5152/tftrd.2015.48753

Cited by 9 publications

(15 citation statements)

References 30 publications

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“…The prevalence of arm lymphedema varies from 9 to 40% as reported by other studies. 2,3,11,12,14,16 This wide variation in prevalence might be due to lack of consensus regarding method of assessment and timing of assessment for arm lymphedema.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Arm Lymphedema among Patients with Breast Cancer Surgery

Pandey

Shrestha

2016

J Coll Med Sci-Nepal

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Background & Objectives: Lymphedema is a common complication of cancer therapeutics; its prevalence, treatment outcomes, and costs have been poorly defined. It is potentially debilitating condition in breast cancer survivors which negatively affects the quality of life. This study aims to assess the prevalence of arm lymphedema among patients with breast cancer surgery.Materials & Methods: A cross-sectional study was conducted to assess the prevalence of arm lymphedema among the women with breast cancer surgery. Purposive sampling technique was used to collect the data from a sample of 66 women of selected hospitals. Data were collected through self constructed structured and semi structured interview based questionnaire which consisted socio demographic information and clinical related factors. Results: Among The overall prevalence of arm lymphedema was found to be seven (10.6%) respondents among the study population. In this study, 41 (62.1%) respondents were < 50 years of age, 13 (19.7%) had education of secondary level, 27 (40.9%) had received radiation therapy, 63 (95.5%) had no history of infection, 54 (81.8%) had undergone modified radical mastectomy, and 56 (84.8%) had involved lymph node resection. Statistically no any significant association was found between these variables.Conclusion: On the basis of the findings, this conclusion has been drawn that prevalence of arm lymphedema among patients with breast cancer surgery was low (10.6%). Moreover no association was found between the prevalence of arm lymphedema, sociodemographic variables and clinical related factors.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Arm Lymphedema among Patients with Breast Cancer Surgery

Pandey

Shrestha

2016

J Coll Med Sci-Nepal

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“…Higher nodal ratio [1.135 (Hazard ratio (HR) 1.037-1.243)] was also found to be associated with higher risk of arm lymphedema (48). Lumpectomy was not a signi cant risk factor for arm lymphedema (38).…”

Section: [Insert Figures 2 and 3]mentioning

confidence: 94%

“…One study (34) reported that individuals with body mass index (BMI) of ≥30 were 6.64 times more likely to develop arm lymphedema than those with BMI ≤17.9. The risk of developing arm lymphedema among breast cancer women with BMI ≥25 ranges from the odds ratio (OR) of 1.5 to 5.9 compared to participants with BMI < 25 (34,38,41,48,52). We obtained a pooled effect estimate OR of 1.98, 95% con dence interval (CI):…”

Section: [Insert Figures 2 and 3]mentioning

confidence: 99%

“…[Insert Figure 5] Axillary radiotherapy treatment is a signi cant risk with an OR ranging from 2.7 to 4.4 (21,38,42). Four studies examined the risk of developing arm lymphedema associated with higher number of lymph node removal among breast cancer survivors (21,38,48,52). The removal of lymph nodes of >25 during mastectomy was associated with a risk of developing arm lymphedema ] among breast cancer woman compared with when less number of lymph nodes were removed (21).…”

Section: [Insert Figures 2 and 3]mentioning

confidence: 99%

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Prevalence and incidence of cancer related lymphedema in low and middle-income countries: A systematic review and meta-analysis.

Torgbenu

Luckett

Buhagiar

et al. 2020

Preprint

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Abstract Background Little is known about the prevalence and incidence in low and middle-income countries (LMICs) of secondary lymphedema due to cancer. This study aims to estimate the prevalence and incidence in LMICs of secondary lymphedema related to cancer and/or its treatment(s) and identify risk factors. Method A systematic review and meta-analysis was conducted. Medline, EMBASE and CINAHL were searched in June 2019 for peer-reviewed articles that assessed prevalence and/or incidence of cancer-related lymphedema in LMICs. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Estimates of pooled prevalence and incidence estimates were calculated with 95% confidence intervals (CI), with sub-group analyses grouping studies according to: country of origin, study design, risk of bias, setting, treatment, and lymphedema site and measurement. Heterogeneity was measured using X ² and I 2 , with interpretation guided by the Cochrane Handbook for Systematic Reviews. Results Of 8766 articles, 36 were included. Most reported on arm lymphedema secondary to breast cancer treatment (n=31), with the remainder reporting on leg lymphedema following gynecological cancer treatment (n=5). Arm lymphedema was mostly measured by arm circumference (n=16/31 studies), and leg lymphedema through self-report (n=3/5 studies). Eight studies used more than one lymphedema measurement. Only two studies that measured prevalence of leg lymphedema could be included in a meta-analysis (pooled prevalence =10.0%, 95%CI 7.0 – 13.0, I 2 =0%). The pooled prevalence of arm lymphedema was 27%, with considerable heterogeneity (95%CI 20.0 – 34.0, I 2 =94.69%, n =13 studies). The pooled incidence for arm lymphedema was 21%, also with considerable heterogeneity (95%CI 15.0 – 26.0, I 2 =95.29%, n =11 studies). There was evidence that higher BMI (>25) was associated with increased risk of arm lymphedema (OR: 1.98, 95%CI 1.45 – 2.70, I 2 =84.0%, P< 0.0001, n =4 studies). Conclusion Better understanding the factors that contribute to variability in cancer-related arm lymphedema in LMICs is an important first step to developing targeted interventions to improve quality of life. Standardising measurement of lymphedema globally and better reporting would enable comparison within the context of information about cancer treatments and lymphedema care.

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“…One study [28] reported that individuals with body mass index (BMI) of ≥30 were 6.64 times more likely to develop arm lymphedema than those with BMI ≤17.9. The risk of developing arm lymphedema among breast cancer women with BMI ≥25 ranges from the odds ratio (OR) of 1.5 to 5.9 compared to participants with BMI < 25 [27,28,30,42,47]. We obtained a pooled effect estimate OR of 1.98, 95% confidence interval (CI): 1.45 to 2.70 (P < 0.0001; I 2 = 84.0%) in a random effect meta-analysis (refer to Fig.…”

Section: Arm Lymphedema Following Breast Cancer Treatmentmentioning

confidence: 99%

Prevalence and incidence of cancer related lymphedema in low and middle-income countries: a systematic review and meta-analysis

et al. 2020

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Background: Little is known about the prevalence and incidence in low and middle-income countries (LMICs) of secondary lymphedema due to cancer. The purpose of the study is to estimate the prevalence and incidence in LMICs of secondary lymphedema related to cancer and/or its treatment(s) and identify risk factors. Method: A systematic review and meta-analysis was conducted. Medline, EMBASE and CINAHL were searched in June 2019 for peer-reviewed articles that assessed prevalence and/or incidence of cancer-related lymphedema in LMICs. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Estimates of pooled prevalence and incidence estimates were calculated with 95% confidence intervals (CI), with subgroup analyses grouping studies according to: country of origin, study design, risk of bias, setting, treatment, and lymphedema site and measurement. Heterogeneity was measured using X 2 and I 2 , with interpretation guided by the Cochrane Handbook for Systematic Reviews. Results: Of 8766 articles, 36 were included. Most reported on arm lymphedema secondary to breast cancer treatment (n = 31), with the remainder reporting on leg lymphedema following gynecological cancer treatment (n = 5). Arm lymphedema was mostly measured by arm circumference (n = 16/31 studies), and leg lymphedema through self-report (n = 3/5 studies). Eight studies used more than one lymphedema measurement. Only two studies that measured prevalence of leg lymphedema could be included in a meta-analysis (pooled prevalence = 10.0, 95% CI 7.0-13.0, I 2 = 0%). The pooled prevalence of arm lymphedema was 27%, with considerable heterogeneity (95% CI 20.0-34.0, I 2 = 94.69%, n = 13 studies). The pooled incidence for arm lymphedema was 21%, also with considerable heterogeneity (95% CI 15.0-26.0, I 2 = 95.29%, n = 11 studies). There was evidence that higher body mass index (> 25) was associated with increased risk of arm lymphedema (OR: 1.98, 95% CI 1.45-2.70, I 2 = 84.0%, P < 0.0001, n = 4 studies).

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A Cross-sectional Study Examining the Risk Factors Associated with Lymphedema and its Prevalence in Breast Cancer Patients after Level 3 Axillary Lymph Node Dissection

Cited by 9 publications

References 30 publications

Prevalence of Arm Lymphedema among Patients with Breast Cancer Surgery

Prevalence of Arm Lymphedema among Patients with Breast Cancer Surgery

Prevalence and incidence of cancer related lymphedema in low and middle-income countries: A systematic review and meta-analysis.

Prevalence and incidence of cancer related lymphedema in low and middle-income countries: a systematic review and meta-analysis

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