A Cross Sectional Study Highlighting the Sensitivity Patterns and Incidence of Extended Spectrum Beta Lactamase Producing Klebsiella oxytoca in Patients with Urinary Tract Infection

Razzaque, Saba Abdul; Aziz, Qamar; Hassan, Syed Furqan; Saboor, Muhammad; SharmeenNaz,; Maheshwary, Neeta; ZarghoonaWajid,; Anwar, Adnan

doi:10.15226/2637-6121/1/1/00102

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…This agrees with Razzaque et al 's study which found Imipenem (94.7%) and Amikacin (92.3%) as the most effective antibiotics for K. oxytoca urinary isolates. They also found sensitivity to Nitrofurantoin (84.6%) and Gentamicin (65.5%), which are different to our results 53 .…”

Section: Percent Of Sensiɵvitycontrasting

confidence: 99%

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Gharavi

Zarei

Roshani-Asl

et al. 2021

Sci Rep

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Nowadays, increasing extended-spectrum β-lactamase (ESBL)-producing bacteria have become a global concern because of inducing resistance toward most of the antimicrobial classes and making the treatment difficult. In order to achieve an appropriate treatment option, identification of the prevalent species which generate ESBL as well as their antibiotic susceptibility pattern is essential worldwide. Hence, this study aimed to investigate the prevalence of ESBL-producing bacteria and assess their drug susceptibility in Fardis Town, Iran. A total of 21,604 urine samples collected from patients suspected to have urinary tract infection (UTI) were processed in the current study. The antimicrobial susceptibility of the isolates was tested by the disk diffusion method. The ESBL producing bacteria were determined by Double Disc Synergy Test (DDST) procedure. Bacterial growth was detected in 1408 (6.52%) cases. The most common bacterial strains causing UTI were found E. coli (72.16%), followed by K. pneumoniae (10.3%) and S. agalactiae (5.7%). Overall, 398 (28.26%) were ESBL producer. The highest ESBL production was observed in E. coli, followed by Klebsiella species. ESBL producers revealed a higher level of antibiotic resistance compared with non-ESBLs. In conclusion, ESBL production in uropathogens was relatively high. Carbapenems and Aminoglycosides were confirmed as the most effective treatment options for these bacteria.

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Section: Percent Of Sensiɵvitycontrasting

confidence: 99%

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Gharavi

Zarei

Roshani-Asl

et al. 2021

Sci Rep

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Understanding how geographic, demographic and treatment history impact health outcomes of patients with multi-drug-resistant tuberculosis in Pakistan, 2014–2017

Iqbal

Defer

Latif³

et al. 2020

Epidemiol. Infect.

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Tuberculosis (TB) is one of the top 10 leading causes of morbidity and mortality worldwide [1]. In 2017, approximately 10 million people were infected with TB and 1.3 million patients faced mortality [1]. Patients with active TB can infect up to 10–15 people over a year. There is a greater risk of transmission in overcrowded areas with limited air ventilation including large family units, prisons and slums [1, 2]. Without proper diagnosis and treatment, roughly 45% of non-HIV positive TB patients face mortality [1]. With the help of global organizations and national TB treatment and control programmes, the global incidence of TB is declining by approximately 2% each year [1]. The World Health Organization (WHO) TB-strategy aims to end the TB epidemic and encourages partners to fund national TB programmes to improve diagnosis and treatment of TB. The goal is to ultimately decrease death rates by 90% and decrease incidence rates by 80% [1]. To achieve these goals, the decline in TB incidence needs to reach approximately 4–5% per year [1]. The WHO 2018 TB report identified multidrug resistant TB (MDR-TB) as the leading factor hindering that goal [1]. The incidence and spread of MDR-TB has drastically increased, where approximately 558 000 new cases of MDR-TB were diagnosed in 2017 causing more than 230 000 deaths globally [1]. MDR-TB is identified by resistance to the two most powerful anti-TB treatment drugs including isoniazid and rifampicin [3]. Patients with MDR-TB are required to start second-line anti-TB drugs (SLDs), which are limited, expensive, less effective and more toxic [1,2]. Therapy duration is one of the major limitations of second-line treatments, which may require up to two years of consistent use. Since TB affects mostly developing countries, long treatment durations and associated costs become a major challenge. In 2015, 15% of new TB cases were reported as MDR-TB, which drastically increased to 24% by 2017 [1]. Even with significant improvements in molecular tests and diagnostic methods, MDR-TB is still on the rise where the success rate of treatments is between 50 and 60% [1]. Additional characteristics including socioeconomic and sociocultural factors need to be considered when targeting and treating patients with MDR-TB.

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Antibiotic susceptibility pattern of E. coli causing urinary tract infection in pregnant women in Al-Najaf Province, Iraq

Hasan,

Aljanaby,

Al-Labban

et al. 2023

AIP Conference Proceedings

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A Cross Sectional Study Highlighting the Sensitivity Patterns and Incidence of Extended Spectrum Beta Lactamase Producing Klebsiella oxytoca in Patients with Urinary Tract Infection

Cited by 4 publications

References 12 publications

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Comprehensive study of antimicrobial susceptibility pattern and extended spectrum beta-lactamase (ESBL) prevalence in bacteria isolated from urine samples

Understanding how geographic, demographic and treatment history impact health outcomes of patients with multi-drug-resistant tuberculosis in Pakistan, 2014–2017

Antibiotic susceptibility pattern of E. coli causing urinary tract infection in pregnant women in Al-Najaf Province, Iraq

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