A Cross-sectional Study of Prevalence and Implications of Depression and Anxiety in Psoriasis

Lakshmy, Sreelatha; Balasundaram, Sivaprakash; Sarkar, Sukanto; Audhya, Moutusi; Subramaniam, Eswaran

doi:10.4103/0253-7176.168587

Cited by 47 publications

(33 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies have demonstrated high rates of depression among psoriatic patients, regardless of psoriasis severity [ 14 ]. The association between depression and duration of psoriasis found by some authors [ 12 ] was not noticed in our patients. As reported in previous studies [ 20 ], female patients were more likely to be depressed than males (SDS 41 ± 9 vs. 33.8 ± 9; p < 0.0001).…”

Section: Discussioncontrasting

confidence: 82%

“…Suffering from psoriasis implies feeling stigmatized, dealing with reduced working possibilities, experiencing shame and worry [ 10 , 11 ]. Psoriatic patients present high rates of anxiety and depression and are at risk of suicidal behavior [ 12 , 13 ]. Some authors reported that depression is independently associated with psoriasis, no matter the severity of skin lesions [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Psychopathological Variables and Sleep Quality in Psoriatic Patients

Luca

Musumeci

et al. 2016

IJMS

View full text Add to dashboard Cite

Psoriasis is an inflammatory disease frequently associated with psychiatric disturbances and sleep disorders. The aim of the study was to assess the prevalence of depression, interaction anxiety, audience anxiety, and sleep quality in psoriatic patients. One hundred and two psoriatic patients were enrolled and underwent the following questionnaires: Zung Self-Rating Depression Scale (SDS), Interaction Anxiousness Scale (IAS), Audience Anxiousness Scale (AAS), Pittsburgh Sleep Quality Index (PSQI). The severity of skin lesions was assessed by Psoriasis Area Severity Index (PASI). The presence of a link between clinical variables and with demographic data has been investigated. Psoriasis was linked to depression, interaction and audience anxiety, as well as to poor sleep quality; 37.5% of patients were depressed, 46.1% scored above 37 at the IAS, 47.1% scored above 33 at the AAS. Thirty-nine subjects (38.2%) presented a PSQI ≥ 5. An association between interaction anxiety and lower limbs psoriasis-related erythema as well as between PSQI and head psoriasis-related erythema was found, particularly among male patients. Hence, psoriatic patients should be assessed from a holistic point of view, in order to identify associated disorders that could benefit from targeted treatments.

show abstract

Section: Discussioncontrasting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Psychopathological Variables and Sleep Quality in Psoriatic Patients

Luca

Musumeci

et al. 2016

IJMS

View full text Add to dashboard Cite

show abstract

“…In previous studies, we and other authors [ 5 , 6 , 11 ] showed a strong association between psoriasis and depressed mood. However, the association of depression with the severity and duration of psoriasis remains less clear [ 15 – 16 ].…”

Section: Discussionmentioning

confidence: 61%

“…Due to this complex pathogenesis, psoriasis rarely presents in isolation, but rather co-occurs with other conditions, such as psychiatric diseases, metabolic syndrome, and alcohol and tobacco dependence [ 1 – 4 ]. Of all conditions that co-occur with psoriasis, depression is the most common, affecting up to 80% of patients with psoriasis [ 5 – 6 ]. In psoriasis, depression worsens both treatment outcomes and prognosis [ 7 ]; for example, it increases the risk of psoriatic arthritis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

Pietrzak

Grywalska

et al. 2018

PLoS ONE

View full text Add to dashboard Cite

ObjectivePsoriasis and depression may have common mechanisms, such as systemic inflammation, dysfunction of the hypothalamic-pituitary-adrenal axis, and vitamin D3 deficiency. Among men with psoriasis, this study examined whether depression severity was associated with serum concentrations of different metabolic and inflammatory markers.MethodsThe study included 85 men with psoriasis (mean age ± standard deviation [SD], 47 ± 14 years) and 65 men without psoriasis (mean age ± SD, 44 ± 13 years). In both groups, we measured the body mass index; blood pressure; and serum concentrations of lipids, uric acid, lipase, interleukins 6 and 18, cortisol, and 25-hydroxyvitamin D3. All participants completed the Beck Depression Inventory. Other variables analyzed included psoriasis duration, the Psoriasis Area Severity Index, and the percentage of body surface area affected by psoriatic lesions.ResultsCompared with controls, patients with psoriasis had significantly greater depression severity, higher body mass indices, and higher serum concentrations of total cholesterol and interleukins 6 and 18; moreover, they had significantly lower serum 25-hydroxyvitamin D3 concentrations. In patients with psoriasis, depression severity correlated positively with psoriasis duration, the Psoriasis Area Severity Index, the percentage of body surface area affected by psoriatic lesions, and interleukin-18 concentration. In patients with psoriasis, depression severity correlated negatively with 25-hydroxyvitamin D3 concentration, but it did not correlate significantly with the serum concentrations of interleukin 6 and cortisol.ConclusionsHigh concentrations of interleukin 18 and low concentrations of 25-hydroxyvitamin D3 may be associated with depression severity in men with psoriasis. Thus, further studies should examine whether effective anti-inflammatory treatments or vitamin D3 supplementation can improve depression outcomes in these patients.

show abstract

“…Lakshmy et al, in across-sectional study on 90 patients in India suffering from psoriasis, with the majority of psoriasis vulgaris (75.6%) [38], showed that 71 of the subjects (78.9%) had major depressive disorder and 69 patients (76,6%) had anxiety. Additionally, it was reported that 51 were dealing with significant stress and that 24 patients (16.6%) assessed their quality of life from 'poor' to 'very poor'.…”

Section: Depression In Psoriasismentioning

confidence: 99%

Occurrence of depression in patients with psoriasis – the role of inflammation, stress and mechanism of the vicious circle

Kuchnicka¹,

Zielińska²,

Kosz³

et al. 2020

J Pre Clin Clin Res.

View full text Add to dashboard Cite

Introduction. Psoriasis is a chronic skin disease which can have a detrimental impact on the patient's life. The correlation between depression, psoriasis and inflammation is a subject of many publications. The depressive and psoriatic symptoms, unhealthy coping strategies and stigmatization might be presented in the mechanism of the vicious circle. The appropriate understanding of this phenomenon might be extremely useful for specialists to improve their bedside manner. Objective. The aim of this review is to analyze the current data about the worldwide presence of the major depressive disorder-psoriasis, and the occurrence of depression in patients suffering from psoriasis. Research and analysis were based on searching sources such as PubMed, UpToDate and World Health Organization pages for the integrative publications collected mainly from last 10 years. The data about the origin of the psoriasis disease was taken from as 1979 publication. State of knowledge. The study demonstrated that the link between psoriasis and depression is bi-directional. The proinflammatory cytokine, such as IL-6, TNF-α, CRP and IL-17, are elevated in both cases, which provokes the exacerbation of sickness symptoms. The inflammation dangerously disturbs the functioning of neuronal system and human homeostasis. Summary. According to the cited research, the prevalence of depressive disorders in psoriatic patients is higher in comparison to people without psoriasis. Inflammation plays an essential role by being a peculiar connector between psoriasis and depression. Stress and inflammation are crucial factors in pathogenesis of those two disorders and triggers the pathological mechanisms.

show abstract

A Cross-sectional Study of Prevalence and Implications of Depression and Anxiety in Psoriasis

Cited by 47 publications

References 36 publications

Psychopathological Variables and Sleep Quality in Psoriatic Patients

Psychopathological Variables and Sleep Quality in Psoriatic Patients

Serum concentrations of interleukin 18 and 25-hydroxyvitamin D3 correlate with depression severity in men with psoriasis

Occurrence of depression in patients with psoriasis – the role of inflammation, stress and mechanism of the vicious circle

Contact Info

Product

Resources

About