A cross-sectional study: serum CCL3/MIP-1&amp;alpha; levels may reflect lumbar intervertebral disk degeneration in Han Chinese people

Zhang, Yili; Li, Bei; Zhou, Zeng-Huan

doi:10.2147/jpr.s152349

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…It may be relevant to briefly relate the five most important saliva proteins (MIP-1α/CCL3, I-TAC/CXCL11, MCP-4/CCL13, MIP-3β/CCL19 and IL-2) to studies concerning nociception and pain. The chemokine MIP - 1α/CCL3 has inflammatory properties ( 79 ), and elevated blood levels have been reported in chronic widespread pain (mainly FM), lumbar intervertebral disk degeneration, migraine, and prostatitis pelvic pain ( 75 , 80 – 82 ). I - TAC/CXCL11 is a proinflammatory chemokine and increased blood levels have been found in FM and in endometriosis patients ( 79 , 83 , 84 ).…”

Section: Discussionmentioning

confidence: 99%

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Gerdle,

Dahlqvist Leinhard,

Lund

et al. 2024

Front. Pain Res.

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ObjectivesThis explorative study analyses interrelationships between peripheral compounds in saliva, plasma, and muscles together with body composition variables in healthy subjects and in fibromyalgia patients (FM). There is a need to better understand the extent cytokines and chemokines are associated with body composition and which cytokines and chemokines differentiate FM from healthy controls.MethodsHere, 32 female FM patients and 30 age-matched female healthy controls underwent a clinical examination that included blood sample, saliva samples, and pain threshold tests. In addition, the subjects completed a health questionnaire. From these blood and saliva samples, a panel of 68 mainly cytokines and chemokines were determined. Microdialysis of trapezius and erector spinae muscles, phosphorus-31 magnetic resonance spectroscopy of erector spinae muscle, and whole-body magnetic resonance imaging for determination of body composition (BC)—i.e., muscle volume, fat content and infiltration—were also performed.ResultsAfter standardizing BC measurements to remove the confounding effect of Body Mass Index, fat infiltration and content are generally increased, and fat-free muscle volume is decreased in FM. Mainly saliva proteins differentiated FM from controls. When including all investigated compounds and BC variables, fat infiltration and content variables were most important, followed by muscle compounds and cytokines and chemokines from saliva and plasma. Various plasma proteins correlated positively with pain intensity in FM and negatively with pain thresholds in all subjects taken together. A mix of increased plasma cytokines and chemokines correlated with an index covering fat infiltration and content in different tissues. When muscle compounds were included in the analysis, several of these were identified as the most important regressors, although many plasma and saliva proteins remained significant.DiscussionPeripheral factors were important for group differentiation between FM and controls. In saliva (but not plasma), cytokines and chemokines were significantly associated with group membership as saliva compounds were increased in FM. The importance of peripheral factors for group differentiation increased when muscle compounds and body composition variables were also included. Plasma proteins were important for pain intensity and sensitivity. Cytokines and chemokines mainly from plasma were also significantly and positively associated with a fat infiltration and content index.ConclusionOur findings of associations between cytokines and chemokines and fat infiltration and content in different tissues confirm that inflammation and immune factors are secreted from adipose tissue. FM is clearly characterized by complex interactions between peripheral tissues and the peripheral and central nervous systems, including nociceptive, immune, and neuroendocrine processes.

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Section: Discussionmentioning

confidence: 99%

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Gerdle,

Dahlqvist Leinhard,

Lund

et al. 2024

Front. Pain Res.

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“…Nevertheless, future mechanistic studies with IL-1 receptor-blocking antibodies will enable us to better understand how IL-1β induction by C. acnes from disc cells could modulate other inflammatory mediators. Previous investigations have shown that expression levels of IL-6, IL-8, CCL3 and CCL4 increase in degenerate IVDs where they appear to play pivotal roles in disc tissue remodelling and nerve sensitisation [ 55 , 56 , 57 ]; furthermore, serum levels of IL-6, IL-8 and CCL3 are elevated in patients with disc degeneration, and the release of a cytokine cocktail from disc cells can also activate a pro-inflammatory response from bone marrow cells, which could potentially lead to the development of Modic changes [ 45 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the Opportunistic Pathogen Cutibacterium acnes

Capoor

Konieczna

McDowell

et al. 2021

IJMS

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Previously, we proposed the hypothesis that similarities in the inflammatory response observed in acne vulgaris and degenerative disc disease (DDD), especially the central role of interleukin (IL)-1β, may be further evidence of the role of the anaerobic bacterium Cutibacterium (previously Propionibacterium) acnes in the underlying aetiology of disc degeneration. To investigate this, we examined the upregulation of IL-1β, and other known IL-1β-induced inflammatory markers and neurotrophic factors, from nucleus-pulposus-derived disc cells infected in vitro with C. acnes for up to 48 h. Upon infection, significant upregulation of IL-1β, alongside IL-6, IL-8, chemokine (C-C motif) ligand 3 (CCL3), chemokine (C-C motif) ligand 4 (CCL4), nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), was observed with cells isolated from the degenerative discs of eight patients versus non-infected controls. Expression levels did, however, depend on gene target, multiplicity and period of infection and, notably, donor response. Pre-treatment of cells with clindamycin prior to infection significantly reduced the production of pro-inflammatory mediators. This study confirms that C. acnes can stimulate the expression of IL-1β and other host molecules previously associated with pathological changes in disc tissue, including neo-innervation. While still controversial, the role of C. acnes in DDD remains biologically credible, and its ability to cause disease likely reflects a combination of factors, particularly individualised response to infection.

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“…CCL2, CCL5, CXCL6, CXCL12, CXCL20, C-X-C receptor 4 (CXCR4), and stromal cell-derived factor 1 (SDF1) expression is considerably elevated in IDD tissues [159][160][161][162][163]. Serum CCL3, CXCL12, and SDF1 levels have also been demonstrated to be positively associated with the degree of IDD [137,162,164,165]. Chemokines may have a role in IDD through a variety of pathways.…”

Section: Chemokinesmentioning

confidence: 99%

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration

Yang

Hai

et al. 2023

Mediators of Inflammation

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Intervertebral disc degeneration (IDD) is a major contributor to back, neck, and radicular pain. It is related to changes in tissue structure and function, including the breakdown of the extracellular matrix (ECM), aging, apoptosis of the nucleus pulposus, and biomechanical tissue impairment. Recently, an increasing number of studies have demonstrated that inflammatory mediators play a crucial role in IDD, and they are being explored as potential treatment targets for IDD and associated disorders. For example, interleukins (IL), tumour necrosis factor-α (TNF-α), chemokines, and inflammasomes have all been linked to the pathophysiology of IDD. These inflammatory mediators are found in high concentrations in intervertebral disc (IVD) tissues and cells and are associated with the severity of LBP and IDD. It is feasible to reduce the production of these proinflammatory mediators and develop a novel therapy for IDD, which will be a hotspot of future research. In this review, the effects of inflammatory mediators in IDD were described.

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A cross-sectional study: serum CCL3/MIP-1α levels may reflect lumbar intervertebral disk degeneration in Han Chinese people

Cited by 5 publications

References 36 publications

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Pain and the biochemistry of fibromyalgia: patterns of peripheral cytokines and chemokines contribute to the differentiation between fibromyalgia and controls and are associated with pain, fat infiltration and content

Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the Opportunistic Pathogen Cutibacterium acnes

Regulatory Effect of Inflammatory Mediators in Intervertebral Disc Degeneration

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