A cross-sectional study to investigate the correlation between depression comorbid with anxiety and serum lipid levels

Wang, Jinmin; Jiang, Changying; Chen, Liling; Song-ying, WU; Lin, Jushan; Gao, Lili; Xie, Buni; Zheng, Dengzi; Yang, Ruiling; Li, Shiju; Pan, Xiaoming; Liao, Yuansheng

doi:10.1016/j.comppsych.2016.05.005

Cited by 24 publications

(11 citation statements)

References 28 publications

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“…There was a negative correlation between BDI scores and HDL in our present study. These findings are consistent with those of previous studies showing decreased HDL levels in depressed individuals [6,7]. By contrast, Baek et al reported that high HDL levels were associated with a recent suicide attempt in patients with a major depressive disorder [24].…”

Section: Discussionsupporting

confidence: 92%

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Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

et al. 2017

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Background Depression is a neuroprogressive disorder that is characterized by neurotransmitter derangement and decreased neurogenesis and neurotrophic factors including brain-derived neurotrophic factor (BDNF). Objectives To determine the lipid profiles and BDNF levels in university students at an institution in Iran and association of these factors with Beck Depression Inventory (BDI) scores. Methods We conducted an observational study of a cross-section of male students at the Ahvaz Jundishapur University of Medical Sciences in Iran. For each of the 100 participants, a BDI score was obtained and serum levels of BDNF were measured by enzyme-linked immunosorbent assay. Levels of serum lipids, including cholesterol, triglycerides, low-density lipoprotein (LDL), and high-density lipoprotein (HDL), were measured using a biochemical analyzer. Castelli’s risk index type I (CRI-I), Castelli’s risk index type II (CRI-II), CRI-I = TG/HDL-C and CRI-II = LDL-cholesterol/ HDL-cholesterol, and atherogenic index of plasma (AIP), AIP = log (triglycerides/HDL-cholesterol), were calculated. Results Based on BDI scores, lower levels of BDNF, triglycerides, cholesterol, and HDL, but higher levels of LDL were found in participants with higher BDI scores. CRI-I was also increased in participants with depression. Conclusion The levels of BDNF and lipid factors are associated with the severity of depression in Iranian male university students. Deranged levels of BDNF and lipids may predispose depressed students to cardiovascular diseases.

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Section: Discussionsupporting

confidence: 92%

“…Depression is associated with metabolic changes such as decreased cholesterol and high-density lipoprotein cholesterol (HDL-C) levels, and increased triglyceride level [6][7][8]. Lipid disorders lead to increased atherogenic potential.…”

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confidence: 99%

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

et al. 2017

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“…Each item contains a number of symptoms, and each group of symptoms is rated from 0 (not at all) to 4 (most severe) [34]. The inter-rater reliability of the scale was 1.00 in a Chinese sample [38].…”

Section: The Hamilton Anxiety Rating Scalementioning

confidence: 99%

Family Relationships, Personality Disorder Functioning Styles and Emotional States in Generalized Anxiety and Major Depressive Disorders

Yu¹,

Xu²,

Zhu³

et al. 2021

Preprint

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Objective: Family relationship affects personality development and emotional regulation, which might be more pronounced in generalized anxiety (GAD) and major depressive (MD) disorders. Method: Thirty patients with GAD, 31 MD, and 32 healthy volunteers answered the Family Relationship Questionnaire (FRQ), the Parker Personality Measure (PERM), and the Hamilton Anxiety and Depression Rating Scales. Results: Compared to healthy controls, both patient groups scored higher on FRQ Paternal Abuse and Paternal Dominance, and lower on Maternal Freedom Release; GAD in addition scored lower on Maternal Abuse and Maternal Dominance. All PERM scale scores except Narcissistic were higher in MD than those in GAD, and all scale scores except Schizotypal and Narcissistic were higher in MD than in controls. Maternal Encouragement was associated with the Paranoid and Schizotypal styles, and Maternal Freedom Release the Avoidant and Borderline in GAD; and Maternal Encouragement the Paranoid, Paternal Dominance the Avoidant, Paternal Freedom Release (-) and Maternal Freedom Release the anxiety, and the Dependent the depression in MD. Conclusions: Our study demonstrates different associations between family relationships and personality traits/ emotional states in MD and GAD, suggesting different forms of family therapy for the two disorders.

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“…Negative correlations between anxiety and high-density lipoprotein (HDL) levels were observed, while higher triglyceride levels were observed in patients with depression and comorbid anxiety compared to depressive patients without anxiety [ 46 ]. Furthermore, serum triglycerides, very-low-density lipoprotein (VLDL)-cholesterol and free-cholesterol were higher in patients with anxiety disorders as compared to healthy controls, whereas the opposite was observed for esterified cholesterol [ 47 ].…”

Section: Metabolomics To Differentiate Healthy and Anxiety Subjectmentioning

confidence: 99%

Metabolomic Biomarkers in Anxiety Disorders

Humer

Pieh

Probst

2020

IJMS

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Anxiety disorders range among the most prevalent psychiatric disorders and belong to the leading disorders in the study of the total global burden of disease. Anxiety disorders are complex conditions, with not fully understood etiological mechanisms. Numerous factors, including psychological, genetic, biological, and chemical factors, are thought to be involved in their etiology. Although the diagnosis of anxiety disorders is constantly evolving, diagnostic manuals rely on symptom lists, not on objective biomarkers and treatment effects are small to moderate. The underlying biological factors that drive anxiety disorders may be better suited to serve as biomarkers for guiding personalized medicine, as they are objective and can be measured externally. Therefore, the incorporation of novel biomarkers into current clinical methods might help to generate a classification system for anxiety disorders that can be linked to the underlying dysfunctional pathways. The study of metabolites (metabolomics) in a large-scale manner shows potential for disease diagnosis, for stratification of patients in a heterogeneous patient population, for monitoring therapeutic efficacy and disease progression, and for defining therapeutic targets. All of these are important properties for anxiety disorders, which is a multifactorial condition not involving a single-gene mutation. This review summarizes recent investigations on metabolomics studies in anxiety disorders.

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A cross-sectional study to investigate the correlation between depression comorbid with anxiety and serum lipid levels

Cited by 24 publications

References 28 publications

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Serum lipids and brain-derived neurotrophic factor in a cross-section of male students with symptoms of depression at a university in Iran: an observational study

Family Relationships, Personality Disorder Functioning Styles and Emotional States in Generalized Anxiety and Major Depressive Disorders

Metabolomic Biomarkers in Anxiety Disorders

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